Navigation Links
Gene Therapy May Be the Solution for Erectile Dysfunction

The latest issue of Human Gene Therapy has published the findings of the first human test involving gene transfer therapy to treat erectile dysfunction.// The finding shows that gene therapy negates the patients’ requirement for on-demand drugs, since gene therapy is beneficial for months, and hence could be the most preferred treatment for erectile dysfunction.

Lead author Arnold Melman, M.D., professor and chair of the Department of Urology at Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center, says, “This is an exciting field of research because current treatments for men with erectile dysfunction, whether pills or minimally invasive therapies, must be used ‘on demand’, thereby reducing the spontaneity of the sexual act.”

Erectile dysfunction affects more than 50 percent of men aged 40 to70 and 70 percent above age 70, according to the Massachusetts Male Aging Study.

Dr. Melman and two study centers worked with 11 men and administered various doses of a transfer gene called hMaxi-K. “While this phase 1 safety trial was not designed to provide efficacy answers, one patient in each of the higher dose groups (5000 and 7500 micrograms) reported clinically significant and sustained improvements in ED. And, there have been no adverse effects with the patients in the study, so it has been proven to be safe,” he adds.

Because there has been widely publicized adverse results using viruses as agents to transfer genes into humans, Dr. Melman has chosen to transfer the hMaxi-K gene using “naked DNA,” a form of circular DNA which remains independent and does not integrate with chromosomal DNA in the muscle cells.

“The hMaxi-K stimulates potassium ion transfer in the smooth muscle cells of the penis,” says Dr. Melman. The hMaxi-K gene works by creating additional potassium channels (the chemical symbol for potassium is ‘K’) in the smooth muscle cell of the penis. Thi s relaxes the muscle and allows blood flow required for an erection.

“Because this novel therapeutic approach of ion channel therapy works on smooth muscle, it is also promising for overactive bladder disease,” adds Dr. Melman.

Dr. Melman, with George Christ, PhD, developed the process for ion channel therapy at the Albert Einstein College of Medicine, which owns the patents. Montefiore is the academic medical center for Einstein. Einstein has granted licensing rights for the patent to a company called Ion Channel Innovations, which was founded by Dr. Melman, and under whose sponsorship the clinical trials are being conducted. The two study centers in the trials were Mount Sinai Medical Center and NYU Medical Center.



Source-Eurkalert
SAV
'"/>




Related medicine news :

1. Cancer Doctors Okays Controversial Prostate Therapy
2. Consensus on "Combination Therapy" for Breast Cancer
3. Gene Therapy shows promise in treating Hemophilia
4. "Make AIDS Therapy affordable" - Physicians demand
5. Hormone replacement Therapy a headache
6. Simple Therapy
7. Therapy for stopping the spread of cancer cells
8. Gene Therapy Destroys Pancreatic Cancer Cells
9. Letrozole Beats Tamoxifen in Breast Cancer Therapy
10. Garlic Supplements Impede HIV Therapy
11. Gene Therapy For Cystic Fibrosis
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/9/2016)... (PRWEB) , ... February 10, 2016 , ... The ... the need to “level the playing field .” , As corresponding author Dr John ... we use to categorize and diagnose our chronic pain patients. ‘Chronic cancer pain’ ...
(Date:2/9/2016)... ... February 09, 2016 , ... IsoComforter, Inc., one of the ... newly designed, innovative shoulder wrap. The newly designed shoulder wrap has been ... arm and shoulder to promote faster healing. It is highly recommended for arm ...
(Date:2/9/2016)... ... 09, 2016 , ... Shark Finds and Kevin Harrington, and the Product Managers of ... GRIP-DRY is a newly patented product that has solved some of the basic problems golfers ... early morning dew or right after a rain shower, might understand the struggle of placing ...
(Date:2/8/2016)... Peachtree City, GA (PRWEB) , ... February 08, 2016 , ... ... healthy and cavity-free. February is National Children’s Dental Health Month and family dentist Yvonne ... to 3 p.m. at Coast Dental , located next to Target at 1207 ...
(Date:2/8/2016)... ... February 08, 2016 , ... If you are feeling ... handle, you are not alone. According to the Center for Disease Control and Prevention ... type 2 diabetes and certain types of cancer, some of the leading causes of ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... , Feb. 9, 2016 This TforG report ... reported by the ICD-9 coding system in ... surgical procedure volumes, the report provides written and numerical ... the local markets. In addition, the latest reforms of ... --> --> The report helps ...
(Date:2/9/2016)... LONDON , Feb. 9, 2016 The new report ... Forecast: 2015-2019" by Spearhead Acuity Business Research & Consulting group reveals ... fetal and neonatal market with a share of 36.4% in 2014 ... North America , the report also covers market analysis for ... Europe , Asia-Pacific , ...
(Date:2/9/2016)... 2016  The Parenteral Drug Association, Inc. (PDA), ... manufacturing sterile drug products, today announced the publication ... – With link to Comparison Spreadsheet. The ... U.S. FDA, the EU, the Pharmaceutical Inspection Convention/Scheme ... --> --> PDA,s Global Sterile ...
Breaking Medicine Technology: