Navigation Links
Gene Therapy For Bubble Baby Syndrome May Lead To Blood Cancer

Gene transplant, a technique to treat the so-called bubble babies, afflicted with a genetic disorder called Severe Combined Immunodeficiency (SCID), may actually be causing more harm// to the patient than thought. It is now suggested that the gene transplant procedure activates a cancer-causing gene, predisposing the patient to leukemia and death.

Reports of leukemia related death of a young boy as a consequence of gene therapy trial treatment of SCID has raised concerns about the use of this technique as a cure for this serious hereditary immune disorder.

Mutation in a gene called IL2RG is known to cause SCID. The protein product of this gene plays a crucial role in the growth of immune cells. Any abnormality in this protein leads to an increased susceptibility to infections. Children suffering from this disease therefore have to protected in a sterile environment (a bubble like encasement) and hence the name.

Gene therapy or rather gene transplant involves introduction of the corrected version of the gene (normal gene) into the body. A study conducted on mice at the Salk Institute in California under the guidance of Prof Inder Verma highlights that this gene replacement can trigger cancer. The result of this controveraisl study is published in the most prestigious Nature journal.

Nearly one third of the mice treated with the normal version of the IL2RG gene developed a form of blood cancer. 'Curing X-SCID by replacing IL2RG in the manner it is currently being done puts patients at an increased risk of developing cancer,' said Dr Niels-Bjarne Woods, a researcher involved in the gene therapy trial.

However, Prof Adrian Thrasher, has something different to say. 'On the basis of the data that is published, which is very preliminary, it is quite possible that the effects are caused by the artificially high levels of the gene in the animals. Certainly we and our colleagues have found no evidence for this effect,' he
'"/>




Page: 1 2

Related medicine news :

1. Cancer Doctors Okays Controversial Prostate Therapy
2. Consensus on "Combination Therapy" for Breast Cancer
3. Gene Therapy shows promise in treating Hemophilia
4. "Make AIDS Therapy affordable" - Physicians demand
5. Hormone replacement Therapy a headache
6. Simple Therapy
7. Therapy for stopping the spread of cancer cells
8. Gene Therapy Destroys Pancreatic Cancer Cells
9. Letrozole Beats Tamoxifen in Breast Cancer Therapy
10. Garlic Supplements Impede HIV Therapy
11. Gene Therapy For Cystic Fibrosis
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene Therapy For Bubble Baby Syndrome May Lead Blood Cancer

(Date:1/22/2015)... Dallas, TX (PRWEB) January 22, 2015 ... the issue of experience and person-centeredness in the long-term ... moving towards action across the continuum. The paper, “The ... the Continuum,” engages perspectives and practices of the patient, ...
(Date:1/22/2015)... Carinsurancesavings.biz has released a new blog post presenting ... . , Purchasing an accidental death and dismemberment rider ... type of rider provides benefits if the insured dies in ... lesser form of life insurance. , AD&D is not ...
(Date:1/22/2015)... (PRWEB) January 23, 2015 Recently, Weddingshe.com has ... catalog, and has announced its highest annual revenues in the ... on its popular glamorous wedding dresses. , According to the ... important wedding dress promotions for them in 2015. This point ...
(Date:1/22/2015)... January 22, 2015 EBSCO Information Services ... are expanding their relationship in an effort to further promote ... world. While EBSCO has long made AMA journals available via ... agent for The JAMA Network. , Long known ...
(Date:1/22/2015)... released a new blog post explaining the importance of keeping a ... of an auto insurance policy . , Clients who driver ... their vehicle insurance policies. The safety a vehicle offers from its ... of this, drivers should always carry a first aid kit in ...
Breaking Medicine News(10 mins):Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4Health News:Driving Safe And Other Factors That Make Auto Insurance Affordable! 2
... Model Significantly Improves Patient OutcomesEL SEGUNDO, Calif., March ... kidney care services for those diagnosed with chronic ... a study revealing DaVita,s IMPACT(TM) (Incident Management of ... significantly reduce mortality rates for new dialysis patients. ...
... such as those in Iraq and Afghanistan can be ... multidrug resistant bacteria. The potentially lethal microbes include superbugs ... Acinetobacter baumannii , Pseudomonas aeruginosa , ... K. Murray, from Brooke Army Medical Center, USA, told ...
... repair complex heart defects with a survival rate of ... a happy ending for these children and teens. ... others, with the same condition, may not. , A ... United States shows that several categories of patients with ...
... cut risk by 43 percent, study found , , SUNDAY, ... reducing the incidence of heart attacks and stroke, the ... reducing the rate of blood clots in the veins, ... study, being presented Sunday at the American College of ...
... The allergen breathed in by a person with asthma ... cascade of events to prompt an allergic reaction, said a ... www.bcm.edu ) in Houston in a report that appears online ... particular, MMP7 activates interleukin 25, a key mediator of the ...
... out, projects require care and caution , , SUNDAY, March 29 ... and yard work -- but if they,re not careful, it ... Mishaps with ladders, gardening tools and lawn mowers alone cause ... attention, according to the U.S. Consumer Product Safety Commission. Many ...
Cached Medicine News:Health News:DaVita's IMPACT Program Reduces Mortality for New Dialysis Patients 2Health News:DaVita's IMPACT Program Reduces Mortality for New Dialysis Patients 3Health News:Physicians mending broken hearts 2Health News:Statin Might Help Fight Blood Clots in Veins 2Health News:Statin Might Help Fight Blood Clots in Veins 3Health News:Tips to Avoid Spring Cleaning Mishaps 2
(Date:1/23/2015)... /PRNewswire/-- Harwood Feffer LLP ( www.hfesq.com ) is investigating potential ... ("Advaxis" or the "Company") (NASDAQ: ADXS ), ... to shareholders. On January 21, 2015, an ... Advaxis had misrepresented the clinical data for its ADXS-HPV ...
(Date:1/23/2015)... , Jan. 23, 2015  Now available for sale, The ... support that prevents ankle sprains by cushioning the ankle ... fits securely around the outside of any shoe type ... comfort while still offering protection against sprains. With customers ...
(Date:1/23/2015)... , Jan. 23, 2015 Cord Blood America, Inc. ( ... or the "Company")  filed a Preliminary Proxy Statement, Schedule 14A, ... today, and provides an update for shareholders detailing why a ... requested. Dear Shareholders, As we reflect ...
Breaking Medicine Technology:Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 3Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 4
... , May 7 Speedway Children,s Charities and the ... to deliver the gift of hearing to more than 70 underserved children ... to 4pm , at Charlotte Motor Speedway.  Members of the ... welcome by Justin Osmond at 11:00am in the "Victory ...
... Each morning, Margaret Adkins rolls from the bedroom in her apartment to the ... may visit with a friend in their senior citizens complex. Her morning activities are possible ... , , ... , Adkins, 70, had a ...
Cached Medicine Technology:The Gift of Hearing Will be Delivered Free to Over 75 Beneficiaries, as Speedway Children's Charities and the Starkey Hearing Foundation Host 'Get in Gear to Help Children Hear' 2Power Mobility: Independence and Joy for Medicare Patients 2Power Mobility: Independence and Joy for Medicare Patients 3Power Mobility: Independence and Joy for Medicare Patients 4
... is our most popular Low ... It offers a wide field ... and hence a slightly shorter ... be mounted to virtually and ...
The Redi-glaze spectacle magnifier is an aspheric lens, glazed into a standard Keeler LVA frame....
This set is designed to introduce the low vision practitioner to the Keeler telescopic system....
... up to 20 tilting ... in the vertical, horizontal ... the option to offset ... transillumination., ,Filters include Cobalt ...
Medicine Products: