Navigation Links
Gene Therapy Eradicates Pancreatic Cancer in Mice

Researchers at the University of Texas M. D. Anderson Cancer Center have found in pre-clinical trials that a molecularly engineered therapy selectively embeds a gene in pancreatic cancer that shrinks or eradicates tumours, inhibits metastasis, and prolongs survival virtually without toxicity.

"This vehicle, or vector, is so targeted and robust in its cancer-specific expression that it can be used for therapy and perhaps for imaging," notes senior author Dr. Mien-Chie Hung, Professor and Chair of Department of Molecular and Cellular Oncology at the institution.

In a report published in the journal Cancer Cell, the researchers have described the system as a versatile expression vector-nicknamed VISA. It includes a targeting agent that is also called a promoter, two components that boost gene expression in the target tissue, and a payload that is a gene known to kill cancer cells in this case.

All these are packaged in a fatty ball called liposome, and delivered through veins.

"This looks like a promising approach to gene therapy for pancreatic cancer and we are working to bring it to a clinical trial," says Dr. James Abbruzzese, Professor and Chair of the M. D. Anderson Department of Gastrointestinal Oncology.

It may take around one to two years to complete U.S. Food and Drug Administration requirements for a Phase I trial, he says.

In a study, the researchers loaded the VISA system with a mutant version of a gene named BiK, which expresses a protein that naturally forces cancer cells to kill themselves, in two different types of mice. Boffins created the more lethal mutant and named it BikDD.

Untreated control mice in both experiments all died within 40 days, while mice treated with the mutant gene delivered via a less-targeted viral promoter driven expression system employing cytomegalovirus (CMV) died within 90 days. However, the VISA-BikDD mice lived longer in b
'"/>




Page: 1 2

Related medicine news :

1. Cancer Doctors Okays Controversial Prostate Therapy
2. Consensus on "Combination Therapy" for Breast Cancer
3. Gene Therapy shows promise in treating Hemophilia
4. "Make AIDS Therapy affordable" - Physicians demand
5. Hormone replacement Therapy a headache
6. Simple Therapy
7. Therapy for stopping the spread of cancer cells
8. Gene Therapy Destroys Pancreatic Cancer Cells
9. Letrozole Beats Tamoxifen in Breast Cancer Therapy
10. Garlic Supplements Impede HIV Therapy
11. Gene Therapy For Cystic Fibrosis
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene Therapy Eradicates Pancreatic Cancer Mice

(Date:4/25/2015)... On Friday, April 17, Interstate Batteries ... Best Implementation Award. This award is given to ... of RFID technology to improve its manufacturing, supply chain ... best demonstrates how RFID is delivering real value to ... Live! 2015 in San Diego, the RFID industries annual ...
(Date:4/24/2015)... Illinois (PRWEB) April 24, 2015 Multi ... includes septic tank pumping ( http://www.zeitersseptics.com/multi-customer-discount.html ) of 1000-1500 ... to start the program. This does not include any ... applicable. Save $25-$65 per person. If someone is part ... or two tanks totaling approximately 2500 gallons or more, ...
(Date:4/24/2015)... The Fastest Fat Loss Week Ever, released by Shaun Hadsall ... Fat Loss Diet, has been causing a lot of commotion ... to help one lose belly fat in only 25 days ... investigative review. , "Our Fastest Fat Loss Week Ever ... experimenting with these methods on their clients with great success. ...
(Date:4/24/2015)... The first step to transforming one’s ... For meditation and yoga teacher Stine Koppernæs, meditation and ... tools that allow her to experience more peace and ... a teacher since 2006, and through the years she ... being. , “I love sharing this way of finding ...
(Date:4/24/2015)... April 24, 2015 Integrative Therapeutics ... key pathways: immunity and cognition. , A unique ... helps set ProThrivers™ Wellness Flavonoid Complex apart from ... combination of ingredients to support antioxidation versus the ... unites curcumin, green tea extract, Resveratrol, Alpha-Glycosyl Isoquercitrin, ...
Breaking Medicine News(10 mins):Health News:Seeonic’s Industry Leading Technology Powers Interstate Batteries to Winning Award 2Health News:Zeiter's Septics Inc. Offers Multi Customer Septic Tank Cleaning Program in Cook, Putnam & Will Counties in May 2015 2Health News:Zeiter's Septics Inc. Offers Multi Customer Septic Tank Cleaning Program in Cook, Putnam & Will Counties in May 2015 3Health News:Fastest Fat Loss Week Ever Review Revealed on Healthy & Fit Zone 2Health News:Integrative Therapeutics Introduces Two ProThrivers™ Wellness Supplements with Specialty Ingredients from Kyowa Hakko USA 2Health News:Integrative Therapeutics Introduces Two ProThrivers™ Wellness Supplements with Specialty Ingredients from Kyowa Hakko USA 3Health News:Integrative Therapeutics Introduces Two ProThrivers™ Wellness Supplements with Specialty Ingredients from Kyowa Hakko USA 4
... The Female Health Company,(Amex: FHC ) announced ... which,implements the USAID | DELIVER PROJECT, for the delivery ... Agency for International,Development (USAID) programs., For many years, ... and condoms. The Agency developed an operational plan for,its ...
... mice show curcumin reduces heart enlargement and lowers odds ... -- Curcumin, an ingredient in the curry spice tumeric, ... of heart failure, Canadian researchers say. , The scientists ... General Hospital tested the effects of curcumin in mice ...
... carries same risk as other circulatory problems, experts say. ... suffering from age-related macular degeneration (AMD) have twice the ... researchers report. , The degenerative eye disease is the ... in developed countries and affects the center of the ...
... Inc. (Nasdaq: NHWK ), the leading provider of ... States,today announced that it will present at the Cowen ... 18, 2008, at 11:00 am EDT at the,Boston Marriott ... and,Chief Executive Officer, Andrea Clegg, Vice President of Finance ...
... TORONTO, Feb. 28 /PRNewswire-FirstCall/ - MDS Inc. (TSX: ... services to the global life,sciences markets, announced that ... on Thursday, March 6., The Company will ... P.,DeFalco, President and Chief Executive Officer and Douglas ...
... clubs across the country will become the "Gateway to,Healthy ... transform,their lives and take better care of themselves., ... Annual,Get Active America! program, participating health clubs will open ... can revitalize their lives and,benefit from the supportive environment ...
Cached Medicine News:Health News:The Female Health Company Receives USAID DELIVER PROJECT Order for 6.1 Million Units 2Health News:Curry Ingredient May Cut Cardiovascular Risks 2Health News:Age-Related Macular Degeneration Doubles Heart Attack and Stroke Risk 2Health News:Age-Related Macular Degeneration Doubles Heart Attack and Stroke Risk 3Health News:NightHawk Radiology Holdings, Inc. to Speak at the Cowen and Company 28th Annual Health Care Conference on March 18, 2008 2Health News:Health Clubs Open Doors Free for 5th Annual Get Active America! Month and Become Gateway to Healthy Living 2Health News:Health Clubs Open Doors Free for 5th Annual Get Active America! Month and Become Gateway to Healthy Living 3
(Date:4/24/2015)... April 24, 2015  Blueprint Medicines today announced ... and potent inhibitor of fibroblast growth factor receptor ... of hepatocellular carcinoma (HCC) that are dependent on ... induced complete tumor regression in a subset of ... at the highest dose levels. These data will ...
(Date:4/23/2015)... April 23, 2015 /CNW/ - Health Canada is working ... to update the safety information regarding the risk of ... when these products are used at high doses (at ... and duration of use. Ibuprofen is a ... relief, and to reduce inflammation. The majority of ibuprofen ...
(Date:4/23/2015)... 23, 2015  DanDrit Biotech A/S ("DanDrit Denmark"), ... , Inc. ("DanDrit"), (symbol : OTCQB:DDRT) a ... for the treatment of colorectal cancer, announced that ... signed a partnership agreement in Saudi ... advances DanDrit,s goal to deliver an innovative portfolio ...
Breaking Medicine Technology:Blueprint Medicines Presents New Preclinical Data Demonstrating Its Drug Candidate BLU-554 Induces Significant Tumor Regression in Models of Hepatocellular Carcinoma 2Blueprint Medicines Presents New Preclinical Data Demonstrating Its Drug Candidate BLU-554 Induces Significant Tumor Regression in Models of Hepatocellular Carcinoma 3Information Update - New safety information for prescription-strength ibuprofen: Risk of heart attack and stroke at high doses 2Information Update - New safety information for prescription-strength ibuprofen: Risk of heart attack and stroke at high doses 3Information Update - New safety information for prescription-strength ibuprofen: Risk of heart attack and stroke at high doses 4DanDrit Biotech and Riyadh Pharma Sign Partnership Agreement 2
... a scientifically advanced nutritional formulation that ... full body health. MacularProtect Complete is ... and other advanced research. It features ... a broad foundation of antioxidants, such ...
... is a scientifically advanced multinutrient ... visual and full body health. ... nutrients, including a diverse array ... lutein, lycopene and OptiBerry and ...
Ocuvite® Lutein is an advanced antioxidant supplement formulated to provide nutritional support for the eye....
... The herbal extracts, vitamins, ... formula increases circulation to ocular ... maintains healthy function of the ... eye. This formula is optimized ...
Medicine Products: