Navigation Links
Gene Screening Points Way to More Effective Chemotherapy

f RNA used are called small interfering RNA, or siRNA. In this experiment, four siRNAs targeting a single gene were placed in each well. Overall, the researchers used 84,508 different siRNAs.

Next, the drug paclitaxel was added to each well for two days. By examining the survival of the cells in each well, the researchers determined which genes were involved in affecting the cells’ sensitivity to the drug.

All told, the experiment took more than 150,000 individual pipetting steps over seven weeks to test the drug.

The researchers then re-tested the six genes that showed the most dramatic effect with paclitaxel and tried the same test using the chemotherapy drugs vinorelbine (Navelbine) and gemcitabine (Gemzar), but the results were not as dramatic as those seen for paclitaxel. “Our studies using additional drugs indicate that the genes we uncovered are highly specific for paxlitaxel,” said Dr. Angelique Whitehurst, postdoctoral researcher in cell biology and lead author of the study.

“Being able to do this in human cells, and being able to do it fast – this is very powerful,” Dr. White said. “The idea of the screen was to be able to take advantage of the new generation of technology to silence any gene we want. That’s the power of a genome-wide screen – you go in without any expectations and let the data tell you what’s important.”

Soure-Newswise
SRM
'"/>




Page: 1 2

Related medicine news :

1. Screening device for ovarian cancer
2. Screening bypasses radical breast surgery
3. Screening of Lazy Eye
4. Screening Cost-Effective for Lung Cancer
5. Screening Newborns Questioned
6. Screening For Prostate Cancer in men over 75 Questioned
7. Ultrasound Screening Could Improve The Outcome Of Critically ill Patients
8. The Effectiveness Of Screening Tests Questioned
9. Screening Test For Early Diagnosis Of Colorectal Cancer
10. The Importance Of Skin Cancer Screening
11. Ovarian Cancer Screening Questioned
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene Screening Points Way More Effective Chemotherapy

(Date:7/30/2014)... July 30, 2014 Ticket Down ... at Metlife Stadium in East Rutherford, NJ. Fresh off ... look to get back to their winning ways in international ... MetLife Stadium in East Rutherford, N.J. These two South American ... and will continue their feud when they invade the Northeast ...
(Date:7/30/2014)... A study of high school students by University of ... links between insomnia-related mental health conditions among teens. , ... surveyed more than 300 Australian high school students aged ... condition and the time of day they were most ... published in the journal Sleep Medicine ...
(Date:7/30/2014)... Victory Medical Center Craig Ranch , a ... of a pediatric unit focused on: orthopedics, ear, nose, ... in the pediatrics departments are all specially trained to ... Timothy Cole, Dr. Dale Ehmer, Dr. Barry Humeniuk, Dr. ... Dr. Nicholas Peiffer lead the pediatrics team. Victory Medical ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 Building ENT ... throat, allergy, and audiology practice in Westchester County takes ... state-of-the-art technology, a superb underlying corporate structure and protocols, ... It also takes a leading Chief Financial Officer to ... Journal (WCBJ), that’s exactly what it possesses. In fact, ...
(Date:7/30/2014)... (HealthDay News) -- A simple blood test could help ... research finds. The test would measure the concentration ... women,s red blood cells. The findings from this study -- ... doctors predict the risk of serious birth defects known as ... development of a growing fetus. In addition to naturally ...
Breaking Medicine News(10 mins):Health News:Brazil vs. Ecuador Tickets MetLife Stadium: Ticket Down Slashes Ticket Prices on Ecuador vs. Brazil Tickets in East Rutherford, NJ at MetLife Stadium 2Health News:Brazil vs. Ecuador Tickets MetLife Stadium: Ticket Down Slashes Ticket Prices on Ecuador vs. Brazil Tickets in East Rutherford, NJ at MetLife Stadium 3Health News:Teen insomnia is linked with depression and anxiety 2Health News:Victory Medical Center Craig Ranch Debuts Pediatric Care Unit 2Health News:Victory Medical Center Craig Ranch Debuts Pediatric Care Unit 3Health News:The Leading Ear, Nose, and Throat Practice in Westchester County Has One of the Leading CFO’s in Westchester County! 2Health News:The Leading Ear, Nose, and Throat Practice in Westchester County Has One of the Leading CFO’s in Westchester County! 3Health News:Blood Test Might Help Prevent Certain Birth Defects 2
... useless, the appendix now appears to have a reason to ... living in the human gut. , Drawing upon a series ... that the beneficial bacteria in the appendix that aid digestion ... the intestines and emerge afterwards to repopulate the gut. Their ...
... insights into chronic, illnesses, including heart failure and COPD, from ... ... Calif., Oct. 8 VivoMetrics announced today,that noted researcher Bruce D. Johnson, ... LifeShirt(R) System to,the South Pole to collect valuable data for his ongoing ...
... Prescription Pads with ... Enhanced Patient Features, HASBROUCK ... prescription pads, today announced that,it has appointed Richard Zwickel to ... model. Being launched this,month at the PDMA Sharing Conference in ...
... mothers who survived ... breast cancer, ALPHARETTA, Ga., ... brand, celebrates the "Power of Pink" by,announcing the winners of its "Pink ... women will be recognized,during the Susan G. Komen for the Cure Pink ...
... scrapes and bruises, study found , MONDAY, Oct. 8 (HealthDay ... as a non-lethal way to incapacitate suspects, are generally safe ... say U.S. researchers who reviewed almost 1,000 incidents involving the ... to a Taser had mild injuries (such as scrapes and ...
... to More Than Half the Population of Singapore to Use ... ... Facilities -, BOCA RATON, Fla., ... today announced,that SingHealth, the largest healthcare provider in Singapore, has selected,Eclipsys ...
Cached Medicine News:Health News:Appendix isn't useless at all: It's a safe house for bacteria 2Health News:Appendix isn't useless at all: It's a safe house for bacteria 3Health News:VivoMetrics' LifeShirt Going to South Pole to Uncover Clues to High-Altitude Illness 2Health News:VivoMetrics' LifeShirt Going to South Pole to Uncover Clues to High-Altitude Illness 3Health News:Medi-Promotions Hires Industry Executive to Expand its Medi-Scripts Prescription Pad Model 2Health News:'Pink Power Moms' Unite in Atlanta for Day of Pampering and Recognition 2Health News:'Pink Power Moms' Unite in Atlanta for Day of Pampering and Recognition 3Health News:'Pink Power Moms' Unite in Atlanta for Day of Pampering and Recognition 4Health News:Serious Injury Rare With Police Tasers 2Health News:SingHealth Selects Eclipsys Solutions to Help Improve Clinical Outcomes, First Sunrise Clinical Manager Client Outside of North America 2Health News:SingHealth Selects Eclipsys Solutions to Help Improve Clinical Outcomes, First Sunrise Clinical Manager Client Outside of North America 3
(Date:7/30/2014)... Coordinators, Inc. (PCI) is pleased to announce it has ... Limited (Penn Pharma). Penn Pharma is headquartered in Tredegar, ... Kingdom and operates regional offices in ... Tokyo , Japan. Penn Pharma offers both drug development ... manufacturing, as well as Clinical Packaging, Labeling, and global ...
(Date:7/30/2014)... FOREST, Ill., July 30, 2014  Hospira, Inc. ... provider of injectable drugs and infusion technologies, today ... 30, 2014. Net sales for the quarter were ... were $0.72. (Adjusted* measures exclude specified items as ... attached schedules.) On a U.S. Generally Accepted Accounting ...
(Date:7/30/2014)... VILLAGE, Nev. , July 30, 2014  PDL ... announced that company management will participate in the Jefferies ... Boston , Massachusetts. The conference will occur on August ... About PDL BioPharma, Inc. PDL BioPharma manages ... of its Queen et al. antibody humanization patents and ...
Breaking Medicine Technology:PCI Announces Definitive Agreement to Acquire Penn Pharma 2PCI Announces Definitive Agreement to Acquire Penn Pharma 3PCI Announces Definitive Agreement to Acquire Penn Pharma 4PCI Announces Definitive Agreement to Acquire Penn Pharma 5Hospira Reports Second-Quarter 2014 Results 2Hospira Reports Second-Quarter 2014 Results 3Hospira Reports Second-Quarter 2014 Results 4Hospira Reports Second-Quarter 2014 Results 5Hospira Reports Second-Quarter 2014 Results 6Hospira Reports Second-Quarter 2014 Results 7Hospira Reports Second-Quarter 2014 Results 8Hospira Reports Second-Quarter 2014 Results 9Hospira Reports Second-Quarter 2014 Results 10Hospira Reports Second-Quarter 2014 Results 11Hospira Reports Second-Quarter 2014 Results 12Hospira Reports Second-Quarter 2014 Results 13Hospira Reports Second-Quarter 2014 Results 14Hospira Reports Second-Quarter 2014 Results 15Hospira Reports Second-Quarter 2014 Results 16Hospira Reports Second-Quarter 2014 Results 17Hospira Reports Second-Quarter 2014 Results 18Hospira Reports Second-Quarter 2014 Results 19Hospira Reports Second-Quarter 2014 Results 20Hospira Reports Second-Quarter 2014 Results 21Hospira Reports Second-Quarter 2014 Results 22Hospira Reports Second-Quarter 2014 Results 23Hospira Reports Second-Quarter 2014 Results 24Hospira Reports Second-Quarter 2014 Results 25Hospira Reports Second-Quarter 2014 Results 26Hospira Reports Second-Quarter 2014 Results 27Hospira Reports Second-Quarter 2014 Results 28Hospira Reports Second-Quarter 2014 Results 29Hospira Reports Second-Quarter 2014 Results 30Hospira Reports Second-Quarter 2014 Results 31PDL BioPharma to Participate in Jefferies 2014 Boston Healthcare Summit 2
... Surgical Company (Nasdaq: STAA ), a leading ... today announced that it expects revenue for the fourth ... Revenues for the full year were approximately $55 million, ... increase of approximately 10% in revenues from the core ...
... Nalco (NYSE: NLC ), providing essential ... Water and Process Services division is implementing a price ... or as contracts permit.  Pricing for most Nalco programs ... product mix. Price increases will vary by country and ...
Cached Medicine Technology:STAAR Surgical Announces Fourth Quarter 2010 Revenue Expected to Exceed $14.2 Million 2STAAR Surgical Announces Fourth Quarter 2010 Revenue Expected to Exceed $14.2 Million 3STAAR Surgical Announces Fourth Quarter 2010 Revenue Expected to Exceed $14.2 Million 4Nalco Announces Price Increase 2Nalco Announces Price Increase 3
This versatile convex array abdominal transducer is multi-frequency, offering 5 levels of fundamental frequencies in addition to 4 settings of Harmonic frequencies. This transducer provides superb im...
HST, versatile convex array abdominal transducer is multi-frequency, offering 5 levels of fundamental frequencies in addition to 4 settings of Harmonic frequencies. This transducer provides superb im...
... is ALOKAs answer to the ... Super High Density, versatile convex ... offering 5 levels of fundamental ... settings of Harmonic frequencies. This ...
The versatility of multiple imaging frequencies and a smaller transducer face make this transducer is perfect for intercostal imaging....
Medicine Products: