Navigation Links
Gene Responsible For Mammary Gland Function, When Mutated Results in Leukemias

s a group of specific genes that cooperate to perform a particular function. The group of genes activated by SRF depends on which member of the MKL1 family binds to the SRF protein.

This MKL1-linked SRF pathway is one of two such cellular signaling cascades of biochemical reactions that enable SRF to activate specific genes, according to Morris. The other pathway uses a group of three proteins collectively called TCF. These proteins help SRF bind to SRE DNA sequences and activate the expression of other genes. 'The MKL1 protein is normally active relatively widely throughout the body,' Morris said. 'So we were surprised that the loss of the MKL1 gene had such a limited effect.

This probably reflects the fact that the other two protein members of the MKL1 family also can trigger the SRF pathway, as can TCF.' To study the role of MKL1, the team produced genetically modified mouse embryos that lacked the MKL1 gene (MKL1 -/- mice) and observed what happened in the mice when the gene was absent. The investigators reported that about 40 percent of mouse embryos that lacked MKL1 did not survive to birth, although the mice that did survive appeared normal.

However, the female mice that survived and grew to adulthood were not able to successfully nurse their offspring because they lacked MKL1 and were not able to expel milk from their mammary glands. 'The absence of the MKL1 gene impairs normal development and function of mammary gland muscle genes that depend on SRF,' Morris said. 'These muscles are the ones that contract and cause milk ejection in response to nursing.’ The St. Jude team further demonstrated the normal role of MKL1 by using ‘gene chips' to analyze mammary tissues in MKL1 -/- mice.

The researchers found that there was a significant reduction in activity of a group of genes linked to the development and differentiation (specialization of cells) of the myoepithelial muscle cells in the mammary gland. These muscles, whic
'"/>




Page: 1 2 3

Related medicine news :

1. PET Scan find the Area of Brain Responsible for Anorexia Nervosa
2. Arsenic May Have Been Responsible For The Madness Of King George III Of England
3. Gene That Might Be Responsible For Aging
4. Enzyme Responsible For Congenital Blindness
5. New Virus Held Responsible For Respiratory Infection In Children
6. Researchers Identify Sipa 1 Gene, Responsible For Cancer Metastasis
7. Nurse Held Responsible For Insulin Overdose
8. Coroner Says Sativex Is Responsible For Death Of Patient
9. Alcohol Is Responsible For 60 Different Diseases
10. Scientists Identify Gene Responsible For Depression
11. Genes That Were Responsible For The Cause Of Blindness Identified
Post Your Comments:
(Date:8/28/2014)... Sarasota, FL (PRWEB) August 29, 2014 ... company that brings pharmaceutical industry precision to the ... granted zoning approval for its primary location in ... quickly and decisively with a total commitment to ... look forward to creating," says David Wright, President ...
(Date:8/28/2014)... Illinois (PRWEB) August 29, 2014 Fifty ... feeling tired all the time, twenty percent of Americans ... interfere with their daily life. Adrenal Fatigue is the ... you have more of the classic symptoms. Tasks that ... up over things that previously didn’t cause irritation, experiencing ...
(Date:8/28/2014)... Phoenix, Arizona (PRWEB) August 28, 2014 ... Alliance and long-time friend of Mark Brnovich, was ... for the Republican nomination for the Attorney General seat ... refuse. He quickly gathered the support of Cardinal Hall ... former Arizona Cardinals Derek Kennard and Mark Walczak. Green, ...
(Date:8/28/2014)... Frank DellaCroce and Scott Sullivan, Co-Founders of the ... St. Charles Surgical Hospital (SCSH) in New ... Dr. Craig Ashley Blum has joined their highly skilled ... Blum will work with the team of reconstructive surgeons ... Wise. , “We are excited to have Dr. Blum ...
(Date:8/28/2014)... New Energy Works Timberframe plans for a ... country to Log & Timber Home Shows starting in ... Energy Works team will invite the shows’ attendees into ... expertise, project images, and their new 2015 project calendar. ... Mid-West Representative, will present “A fun-fill odyssey: Realizing your ...
Breaking Medicine News(10 mins):Health News:Sarasota County Approves Zoning for Leading Medical Cannabis Firm AltMed 2Health News:Peoria AlignLife Clinics Focus on Community Education 2Health News:Pro Player Health Alliance Back in the Political Arena 2Health News:Pro Player Health Alliance Back in the Political Arena 3Health News:New Plastic Surgeon Joins Center For Restorative Breast Surgery 2Health News:New Energy Works Timberframers Prepares to Exhibit Timber Framing at Autumn Trade Shows 2Health News:New Energy Works Timberframers Prepares to Exhibit Timber Framing at Autumn Trade Shows 3
... are still common, especially among women, survey finds , WEDNESDAY, ... older people have lower rates of mental illnesses related to ... common, especially in women. , Researchers led by Amy L. ... a survey of 2,575 people aged 55 and older. , ...
... Margaret Hospital (PMH) have discovered that the ovarian hormone ... cells, a finding that has important implications for breast ... in Nature (10.1038/nature09091; http://dx.doi.org/ ), are ... factors for breast cancer, says principal investigator Rama Khokha, ...
... A new study suggests that it may not help older men ... men who talk to their partner report greater happiness and ... to be published in the Journal of Gerontology: Social Sciences ... health and stress in their later years varies greatly and that ...
... 2010 Nausea in pregnant women tends to fade after ... trimesters it can be a sign of flu, researchers at ... expectant women who sought medical care. "People don,t necessarily ... or vomiting, but our study showed that they are common ...
... ... CHOICES Act, and just days after the release of America’s first-ever National ... leaders from the fitness industry are gathering on Capitol Hill as part ... meet with Members of Congress to share their vision for a healthier ...
... vaccine, researchers say , WEDNESDAY, May 5 (HealthDay News) -- ... AIDS, have a gene that gives them a stronger immune ... people exposed to HIV -- about one in every 200 ... disease. Previous research found that a large number of these ...
Cached Medicine News:Health News:PMH cancer researchers link ovarian hormone to breast stem cells growth 2Health News:Friendship and confiding in spouse eases stress over sexual issues in older men 2Health News:Friendship and confiding in spouse eases stress over sexual issues in older men 3Health News:Nausea and speeding heart can be signs of flu in pregnant women 2Health News:Fitness Industry Gathers on Capitol Hill Hours After Healthy CHOICES Act is Introduced, Urging Congress to Pass Anti-Obesity, Exercise Promotion Legislation 2Health News:Fitness Industry Gathers on Capitol Hill Hours After Healthy CHOICES Act is Introduced, Urging Congress to Pass Anti-Obesity, Exercise Promotion Legislation 3Health News:Fitness Industry Gathers on Capitol Hill Hours After Healthy CHOICES Act is Introduced, Urging Congress to Pass Anti-Obesity, Exercise Promotion Legislation 4Health News:Fitness Industry Gathers on Capitol Hill Hours After Healthy CHOICES Act is Introduced, Urging Congress to Pass Anti-Obesity, Exercise Promotion Legislation 5
(Date:8/28/2014)... YORK, Aug. 28, 2014 Reportlinker.com announces ... in its catalogue: North America Aesthetic ... http://www.reportlinker.com/p02343466/North-America-Aesthetic-Lasers-and-Energy-Devices-Market-Outlook-to-2020.html ... Outlook to 2020 Summary GlobalData,s new ... Market Outlook to 2020", provides key market data ...
(Date:8/28/2014)... Aug. 28, 2014  Rigrodsky & Long, P.A.: , ... Inc. (NYSE: LCI )? , Did you purchase ... and July 16, 2014, inclusive? , Did you lose ... Do you want to discuss your rights? ... States Attorney, Timothy J. MacFall , announces that a complaint ...
(Date:8/28/2014)... YORK , Aug. 28, 2014 ... new market research report is available ... Laboratories, Safety and Compliance Services Industry ... and Revenue Forecasts to 2021, NAIC ... .html Testing Laboratories, ...
Breaking Medicine Technology:North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 2North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 3North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 4North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 5North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 6North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 7North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 8North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 9North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 10North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 11North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 12North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 13North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 14North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 15North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 16Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Lannett Company, Inc. 2Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Lannett Company, Inc. 3Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 2Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 3Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 4Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 5Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 6
... 25, 2011 The Coalition for Mercury-free Drugs (CoMeD) ... and vaccine researchers revealing U.S. officials apparently colluded in ... removal of mercury from vaccines. Documents ... show that CDC officials were aware of Danish data ...
... CINCINNATI, Oct. 25, 2011 LCA-Vision Inc. (NASDAQ: ... under the Lasik Plus ® brand, today announced financial and ... 30, 2011. Third Quarter 2011 Financial and ... of 2010) Revenues increased 7.5% to $21.8 ...
Cached Medicine Technology:Scandal Exposed in Major Study of Autism and Mercury 2LCA-Vision Third Quarter Results Feature 7.5% Growth in Revenues and Reduced Operating Loss 2LCA-Vision Third Quarter Results Feature 7.5% Growth in Revenues and Reduced Operating Loss 3LCA-Vision Third Quarter Results Feature 7.5% Growth in Revenues and Reduced Operating Loss 4LCA-Vision Third Quarter Results Feature 7.5% Growth in Revenues and Reduced Operating Loss 5LCA-Vision Third Quarter Results Feature 7.5% Growth in Revenues and Reduced Operating Loss 6LCA-Vision Third Quarter Results Feature 7.5% Growth in Revenues and Reduced Operating Loss 7LCA-Vision Third Quarter Results Feature 7.5% Growth in Revenues and Reduced Operating Loss 8LCA-Vision Third Quarter Results Feature 7.5% Growth in Revenues and Reduced Operating Loss 9LCA-Vision Third Quarter Results Feature 7.5% Growth in Revenues and Reduced Operating Loss 10
Intermittent catheter...
Intermittent catheter...
Intermittent catheter...
Diagnostic and laboratory test reference. Get help with test preparation, interpretation, follow-up, and reimbursement....
Medicine Products: