Navigation Links
Gene Responsible For Mammary Gland Function, When Mutated Results in Leukemias

s a group of specific genes that cooperate to perform a particular function. The group of genes activated by SRF depends on which member of the MKL1 family binds to the SRF protein.

This MKL1-linked SRF pathway is one of two such cellular signaling cascades of biochemical reactions that enable SRF to activate specific genes, according to Morris. The other pathway uses a group of three proteins collectively called TCF. These proteins help SRF bind to SRE DNA sequences and activate the expression of other genes. 'The MKL1 protein is normally active relatively widely throughout the body,' Morris said. 'So we were surprised that the loss of the MKL1 gene had such a limited effect.

This probably reflects the fact that the other two protein members of the MKL1 family also can trigger the SRF pathway, as can TCF.' To study the role of MKL1, the team produced genetically modified mouse embryos that lacked the MKL1 gene (MKL1 -/- mice) and observed what happened in the mice when the gene was absent. The investigators reported that about 40 percent of mouse embryos that lacked MKL1 did not survive to birth, although the mice that did survive appeared normal.

However, the female mice that survived and grew to adulthood were not able to successfully nurse their offspring because they lacked MKL1 and were not able to expel milk from their mammary glands. 'The absence of the MKL1 gene impairs normal development and function of mammary gland muscle genes that depend on SRF,' Morris said. 'These muscles are the ones that contract and cause milk ejection in response to nursing.’ The St. Jude team further demonstrated the normal role of MKL1 by using ‘gene chips' to analyze mammary tissues in MKL1 -/- mice.

The researchers found that there was a significant reduction in activity of a group of genes linked to the development and differentiation (specialization of cells) of the myoepithelial muscle cells in the mammary gland. These muscles, whic
'"/>




Page: 1 2 3

Related medicine news :

1. PET Scan find the Area of Brain Responsible for Anorexia Nervosa
2. Arsenic May Have Been Responsible For The Madness Of King George III Of England
3. Gene That Might Be Responsible For Aging
4. Enzyme Responsible For Congenital Blindness
5. New Virus Held Responsible For Respiratory Infection In Children
6. Researchers Identify Sipa 1 Gene, Responsible For Cancer Metastasis
7. Nurse Held Responsible For Insulin Overdose
8. Coroner Says Sativex Is Responsible For Death Of Patient
9. Alcohol Is Responsible For 60 Different Diseases
10. Scientists Identify Gene Responsible For Depression
11. Genes That Were Responsible For The Cause Of Blindness Identified
Post Your Comments:
(Date:4/23/2014)... methods that can rapidly screen a large cell ... inside that population has been seriously lacking," said ... the Royal Society of Chemistry journal Chemical ... his coworkers have developed a novel technique that ... Chem. Sci. , 2014, DOI: 10.1039/C4SC00578C, http://pubs.rsc.org/en/content/articlelanding/2014/sc/c4sc00578c#!divAbstract ...
(Date:4/23/2014)... - In a country as wealthy as the United States, ... seniors do not have access to adequate food due to ... insecure. , Recent research at the University of Illinois ... (NHANES) revealed that the seniors who are dealing with hunger ... "In 2011, 8.35 percent of Americans over age 60 faced ...
(Date:4/23/2014)... Effects of Midlife Occupational and Leisure Time Physical Activity ... physical activity in midlife increases the risk of mobility ... the risk. This is found in a study which ... The study was conducted at the Gerontology Research Center ... , Heavy physical labor is often repetitive, wears the ...
(Date:4/23/2014)... bottom of Alzheimer,s disease has been a rapidly ... In the latest crook in the research road, ... interaction between proteins associated with the disease. The ... Chemical Neuroscience , could have important implications for ... Nieznanski and colleagues explain that for years, research ...
(Date:4/22/2014)... the last few decades researchers have characterized a set ... and behavior in all types of species, from flies ... identified, but researchers surmise there are more. A team ... of Pennsylvania wondered if big-data approaches could find them. ... by John Hogenesch, PhD, professor of Pharmacology and first ...
Breaking Medicine News(10 mins):Health News:Following a protein's travel inside cells is key to improving patient monitoring, drug development 2Health News:More Americans in their golden years are going hungry 2Health News:Midlife occupational and leisure-time physical activity limits mobility in old age 2Health News:Bioinformatics profiling identifies a new mammalian clock gene 2
... Healthcare Each Sell Financially Challenged Facilities to ... ... HealthLeaders-InterStudy, NASHVILLE, Tenn., April 9, 2008 ,HealthLeaders-InterStudy, a ... ownership continue to,influence the Miami-area market as for-profit HCA Inc. ...
... Support Foundation Programs, MCLEAN, Va., April 9, ... announced the inaugural,Infinitive Championship Series. This unique series ... of running and triathlon races for,points and prizes. ... collect,points from series events in order to qualify ...
... possible to mimic the tactics used by parasites to ... , That is the hope of Dr Shane Grey ... John Dalton from the Institute for the Biotechnology of ... pair has been awarded a $400,000 grant through the ...
... could be missed, harming long-term survival, study suggests , , ... analysis of breast cancer patient survival suggests it might ... node biopsies. , A team of New York City ... to be free of cancerous cells in their sentinel ...
... a MED3OOO company,that delivers EHR technology to physician ... the Ohio State Medical Association,(OSMA), in Columbus, OH, ... by OSMA to help physician groups make the ... Standards of Excellence Program is available exclusively to,OSMA ...
... WASHINGTON, April 9, 2008 Global Health ... saving lives by improving,health throughout the world, ... Washington, D.C. and Vermont locations., Organizational ... implement a new software system to manage ...
Cached Medicine News:Health News:Miami Hospital Market Sees Shift in Ownership of Two Area Facilities 2Health News:Management Consultancy Announces Inaugural Infinitive Championship Series 2Health News:Manipulating the immune system like a parasite 2Health News:Breast Cancer Lymph Node Biopsy May Need Closer Look 2Health News:Breast Cancer Lymph Node Biopsy May Need Closer Look 3Health News:Breast Cancer Lymph Node Biopsy May Need Closer Look 4Health News:InteGreat Selected to Participate in OSMA's Standard of Excellence Program for EHRs 2Health News:InteGreat Selected to Participate in OSMA's Standard of Excellence Program for EHRs 3Health News:Global Health Council Selects Aptify's Association Management Software 2Health News:Global Health Council Selects Aptify's Association Management Software 3
(Date:1/14/2014)... CLEVELAND , Jan. 14, 2014 NineSigma ... will hold its Innovation Leadership Summit , May ... in Cleveland Ohio . ... innovators and organizations committed to breakthrough achievements through open ...
(Date:1/14/2014)... , January 14, 2014 ... Transfer Devices (CSTD) for hazardous drugs, today announced that it ... fourth straight year.   Equashield,s closed ... technicians, pharmacists, nurses and other medical professionals who ...
(Date:1/14/2014)... Spark Therapeutics , a late-stage gene therapy company, has reached ... Phase 3 study for inherited retinal dystrophies caused by mutations in ... , is presenting this and other corporate updates today, at the ... . Marrazzo said Spark was able to achieve its recruitment ...
Breaking Medicine Technology:Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4Equashield's Sales Grow by 60% in 2013 2Spark Therapeutics Achieves Recruitment Goal in Phase 3 Gene Therapy Clinical Study for Inherited Blindness 2Spark Therapeutics Achieves Recruitment Goal in Phase 3 Gene Therapy Clinical Study for Inherited Blindness 3
... Ankle Cryo/Cuff combines the therapeutic benefits of ... and cold to minimize pain. The cuff ... ankle providing maximum cryotherapy. The Ankle Cryo/Cuff ... available in a pediatric size.,All Cryo/Cuffs can ...
... The Air-Stirrup Plus combines the ... an ankle wrap. In addition, a ... each Air-Stirrup Plus and provides information ... components of ankle sprain management.,Each Air-Stirrup ...
... Aircast VenaFlow System (a prophylaxis for DVT), ... styles: calf, foot, and thigh, to suit ... from light, cool, comfortable material to promote ... be placed directly against the skin. With ...
Comfor™ Cast Boot - Rocker Sole - Closed Toe...
Medicine Products: