Navigation Links
Gene Responsible For Mammary Gland Function, When Mutated Results in Leukemias

According to the investigators at St. Jude Children's Research Hospital it was found that a gene responsible for regulating the normal mammary gland function during nursing can also initiate leukemias. //

This gene results in leukemia only if it undergoes mutation and fuses with another gene. The discovery of the normal function of this gene suggests that drugs used to inhibit the activity of its mutated form might be used in leukemia patients with few serious side effects, the researchers said. A report on this finding appears in the July 19 online posting of the August 6 issue of Molecular and Cellular Biology (MCB). The researchers made their discovery while trying to determine the normal functions of a gene called MKL1 (megakaryoblastic leukemia 1), which is part of a mutation that causes acute megakaryoblastic leukemia (AMKL) in children, according to Stephan Morris, M.D., a member of Pathology and Oncology at St. Jude.

AMKL is a leukemia in which megakaryocytes--the bone marrow cells that normally produce the blood platelets that control blood clotting--reproduce uncontrollably. The leukemia mutation caused by the fusion of MKL1 to the gene RBM15 forms the RBM15-MKL1 fusion gene. AMKL resulting from this mutation usually has only a 20 to 25 percent survival rate. 'MKL1 is particularly interesting because it does not appear to be necessary for the normal development of blood cells,' Morris said. 'Yet when it's fused with RBM15, the resulting mutation causes AMKL.

In addition, our finding that MKL1 plays a very limited role in the body suggests that if a drug were developed for leukemia treatment that prevents its abnormal function, such a drug might have only mild side effects.' Morris is senior author of the MCB paper. MKL1 belongs to a family of three proteins, each of which can bind to a protein called SRF, which in turn binds to genes that contain a DNA sequence (section of a gene) called the SRE, Morris said. SRF then activate
'"/>




Page: 1 2 3

Related medicine news :

1. PET Scan find the Area of Brain Responsible for Anorexia Nervosa
2. Arsenic May Have Been Responsible For The Madness Of King George III Of England
3. Gene That Might Be Responsible For Aging
4. Enzyme Responsible For Congenital Blindness
5. New Virus Held Responsible For Respiratory Infection In Children
6. Researchers Identify Sipa 1 Gene, Responsible For Cancer Metastasis
7. Nurse Held Responsible For Insulin Overdose
8. Coroner Says Sativex Is Responsible For Death Of Patient
9. Alcohol Is Responsible For 60 Different Diseases
10. Scientists Identify Gene Responsible For Depression
11. Genes That Were Responsible For The Cause Of Blindness Identified
Post Your Comments:
(Date:8/28/2015)... ... August 28, 2015 , ... An online provider of CPAP machines, masks, supplies, ... CPAP equipment more affordable by offering shipping at no cost to you, directly to ... orders of any size. My Cpap Store is located in Las Vegas, Nevada. , ...
(Date:8/28/2015)... ... , ... For Dallas, the time is nearing for the annual Heart Walk, ... , The American Heart Association hosts their well-known Heart Walk to raise money in ... difference can be made. Walkers can participate in the cause and someone can also ...
(Date:8/28/2015)... ... August 28, 2015 , ... Loved ... might personally be struggling with chemical dependency, may be able to find some ... a results-driven holistic treatment center for addiction located in Western Michigan. Focusing on ...
(Date:8/28/2015)... ... ... Medical Solutions, one of the nation’s largest travel nurse staffing companies, has been ... and will be honored at an awards dinner in Chicago on Wednesday, October ... Work in Healthcare program recognizes outstanding employers in the healthcare industry nationwide. Modern Healthcare ...
(Date:8/28/2015)... ... August 28, 2015 , ... The Quatela Center for Plastic Surgery is excited ... only nonsurgical product approved by the Food and Drug Administration to eliminate submental fat, ... Dr. William Koenig are among the premier cosmetic surgeons in Rochester to offer ...
Breaking Medicine News(10 mins):Health News:My Cpap Store Now Offering Delivery Special 0 Cost to You 2Health News:North Central Surgical Center’s Subsidiary Participates in Walk 2Health News:Best Drug Rehabilitation Releases New Video Outlining Patients' Personal Recovery Stories 2Health News:Best Drug Rehabilitation Releases New Video Outlining Patients' Personal Recovery Stories 3Health News:Medical Solutions Recognized as One of 2015 Best Places to Work in Healthcare 2Health News:Medical Solutions Recognized as One of 2015 Best Places to Work in Healthcare 3Health News:Non-surgical Treatment to Get Rid of The "Double Chin," Kybella™, Now Available at the Quatela Center for Plastic Surgery 2Health News:Non-surgical Treatment to Get Rid of The "Double Chin," Kybella™, Now Available at the Quatela Center for Plastic Surgery 3
... Gordon HealthDay Reporter , MONDAY, July 19 (HealthDay News) ... many people have turned to homeopathic remedies, including products containing zinc. ... and nasal swabs with zinc have most likely caused a loss ... seeing people using the zinc nasal gel. They squirted it in, ...
... Those ubiquitous wires connecting listeners to you-name-the-sounds from invisible ... more likely today, Lady Gaga -- only hint at ... Now a data-driven review by Northwestern University researchers ... Reviews Neuroscience pulls together converging research from the ...
... By Steven Reinberg HealthDay Reporter , TUESDAY, ... increase a soldier,s risk of epilepsy even years later, a ... a penetrating traumatic brain injury have high rates of epilepsy, ... lesion," said lead researcher Jordan Grafman, a senior investigator at ...
... at the International AIDS Conference in Vienna are charging ... bounce to the millions of people in need of ... numbers reported by WHO, the International Treatment Preparedness Coalition,s ... warnings of the global pullback on AIDS commitment and ...
... HealthDay Reporter , MONDAY, July 19 (HealthDay News) -- A ... risk of HIV infection by more than half, according to ... Vienna. The gel contains tenofovir (Viread), an antiretroviral drug ... women in the general population used it in the same ...
... NY JULY 20, 2010 TCT 2010 (Transcatheter ... technologies and practices in interventional cardiology that will directly ... (September 21-25 in Washington, DC), late breaking data from ... cardiology techniques, and the interactions and effectiveness of new ...
Cached Medicine News:Health News:Homeopathic Nasal Zinc Linked to Loss of Smell 2Health News:Homeopathic Nasal Zinc Linked to Loss of Smell 3Health News:Taking music seriously 2Health News:Taking music seriously 3Health News: Brain Injury May Raise Soldier's Epilepsy Risk 2Health News:Writing checks that bounce: World continues to backtrack on HIV treatment 2Health News:Writing checks that bounce: World continues to backtrack on HIV treatment 3Health News:Writing checks that bounce: World continues to backtrack on HIV treatment 4Health News:Writing checks that bounce: World continues to backtrack on HIV treatment 5Health News:Vaginal Gel Cuts Risk of HIV Infection, Study Shows 2Health News:Vaginal Gel Cuts Risk of HIV Infection, Study Shows 3Health News:TCT 2010 to have significant impact on interventional cardiology practices and patient care 2
(Date:8/28/2015)...  With the heroin epidemic in the ... Jacksonville -based Lakeview Health drug and alcohol treatment ... explain why fentanyl is causing a new wave of ... more potent than pharmaceutical grade heroin and often illegally ... of death skyrockets. "Fentanyl can be an ...
(Date:8/28/2015)... , Aug. 28, 2015 ... has announced the addition of the "Investigation ... to their offering. Originally discovered by ... Yoshitomi Pharmaceutical Industries, Ltd) as an inflammatory drug, ... Senju Pharmaceutical Co., Ltd under the trade name ...
(Date:8/28/2015)... -- Today, in final recognition of the Centers for Disease ... Contacts is sharing how to keep lens cases clean.  ... do not properly care for their lens cases are ... Most contact lens wearers understand the importance of ... is sometimes overlooked.  When proper steps to clean a ...
Breaking Medicine Technology:Lakeview Health's Dr. Philip Hemphill Explains Why Heroin Addicts Are Now Dying of Fentanyl Overdoses 2Investigation Report on China's Pranoprofen Market, 2010-2019 21-800 Contacts Shares Tips on How to Clean Lens Cases 2
... ages 40 and older must be better educated about the ... and its potentially serious outcomes, according to a new declaration ... including The Glaucoma Foundation, the Alliance for Aging Research and ... the Group encourages aging Americans to TAKE on Glaucoma ...
... Bacterin International Holdings, Inc. (NYSE Amex: ... graft material and antimicrobial coatings for medical applications, will hold ... p.m. Eastern time to discuss results for the third quarter ... a press release after the close of the market on ...
Cached Medicine Technology:Experts in Eye Care and Aging Call for Renewed Efforts in Glaucoma Detection and Management Among Americans 2Experts in Eye Care and Aging Call for Renewed Efforts in Glaucoma Detection and Management Among Americans 3Experts in Eye Care and Aging Call for Renewed Efforts in Glaucoma Detection and Management Among Americans 4Bacterin International Sets Third Quarter 2011 Conference Call for Thursday, November 10, 2011 at 4:30 p.m. ET 2
Angled shafts, smooth jaws, polished finish....
... insertion of second generation 6 millimeter foldable ... millimeters, and is perfect for clear corneal ... rounded blades provide a secure grip of ... controlled release of the optic through a ...
Autoref / Ker N vision K 5001 has auto fogging, wide view window, near vision reading. Clear 5.6 Inch color monitor. Data screen function. SE Value display function. Quick printer with automatic cutt...
... Supra Auto-Kerato Refractometer combines an auto-refractor, an ... system all in a single, compact unit. ... times the diagnostic capabilities in one-third the ... of the individual instruments. By implementing Topcons ...
Medicine Products: