Navigation Links
Gene-Nanoparticle Gene Transfer Is Better Than Viral Vector Transfer System

Nanoparticles can be used in gene therapy to transfer therapeutic genes in to brain cells //and helps in studying genetic mechanism of brain diseases.

Gene-nanoparticle complexes developed by scientists at the University of Buffalo, has proved to deliver therapeutic genes directly into the brains of living mice, the transfer rate is comparatively higher to transfer rates of viral vectors and the procedure does not cause any side effects. The result of this work is published in this week Proceedings of the National Academy of Sciences (PNAS). This procedure is easier and faster in transferring desired genes compared to non-viral vectors which has very low expression and efficacy rates, especially in vivo. This gene nanoparticle complex also helps to study the genetic mechanism of brain diseases in addition to offering repair mechanism.

The scientists used this technique to activate adult brain stem/progenitor cells in vivo, demonstrating that it may be possible to "turn on" these otherwise idle cells as effective replacements for those destroyed by neurodegenerative diseases, such as Parkinson's.

"Until now, no non-viral technique has proven to be as effective as the viral vectors in vivo," said co-author Paras N. Prasad, Ph.D., executive director of the UB Institute for Lasers, Photonics and Biophotonics, SUNY Distinguished Professor in UB's Department of Chemistry and principal investigator of the institute's nanomedicine program. "This transition, from in vitro to in vivo, represents a dramatic leap forward in developing experimental, non-viral techniques to study brain biology and new therapies to address some of the most debilitating human diseases."

Viral vectors for gene therapy always carry with them the potential to revert back to wild-type, and some human trials have even resulted in fatalities. Viral vectors can be produced only by specialists under rigidly controlled laboratory conditions. By contrast, the nanoparti
'"/>




Page: 1 2

Related medicine news :

1. Free Tissue Transfer Effective in Treating Massive Skin Cancers
2. Tissue Transfer for Skin Cancer
3. Tissue Transfer For Treatment Of Massive Skin Cancers
4. Transfer Of Rabies Virus Possible From Organ Donor To Recipient
5. Decreasing Multiple Births By Single Embryo Transfers
6. Therapeutic Genes Transferred By Viral Vector Through T Cell Masking
7. Biologicals Transfer Proposal between US and Indian Biotechnology
8. Punjabis Transfer Taste From Chicken To Prawns
9. Transplantation Results in CJD Transfer
10. Transfer of NHS hospital care into the community may not save costs
11. Mother Guilty of Transferring HIV to her Child
Post Your Comments:
(Date:9/30/2014)... 30, 2014 An estimated 40 million ... three years, profoundly impacting health plans’ business models. Atlantic ... upcoming virtual conference, “Private Insurance Exchanges: Bottom-Line Strategies ... on where private health insurance exchanges are today, where ... to look like when they get there. , During ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Julie ... Hudson Allergy , will discuss how restaurants can ... and other special dietary restrictions at the 2014 ... Food Service Professionals, October 21 in New York City. ... incredibly important topic to such an engaged industry audience. ...
(Date:9/30/2014)... September 30, 2014 Computer Resources ... solutions firm based in New York City, has ... Manage360° solution to transform, manage, and support the ... who is a leading provider of innovative services ... self sufficient. The contract will cover the ...
(Date:9/30/2014)... All on Four dental implants ... have received dental implants to vigilant in the fight ... The post, which can be found at http://www.newalbanyimplants.com/dr-rons-blog/ ... don’t brush and floss diligently, they could lose their ... teeth: the bone will deteriorate and the implants will ...
(Date:9/30/2014)... September 30, 2014 Signet Puerto ... based in San Juan, Puerto Rico, leverages RamSoft’s ... , Nivia Souffront, site Administrator for Signet ... “We are excited to bring in PowerServer RIS/PACS/PM ... patient care and physician satisfaction while reducing our ...
Breaking Medicine News(10 mins):Health News:New Atlantic Information Services Virtual Conference Will Detail Private Exchange Strategies for Health Plans 2Health News:Hudson Allergy’s Dr. Julie Kuriakose to Speak at Prestigious Food Allergy Conference in New York City 2Health News:Hudson Allergy’s Dr. Julie Kuriakose to Speak at Prestigious Food Allergy Conference in New York City 3Health News:CRA Awarded Managed Services Contract for Large NYC Nonprofit 2Health News:All on Four Dental Implants Dentist Writes Blog on Preventing Gum Disease 2Health News:All on Four Dental Implants Dentist Writes Blog on Preventing Gum Disease 3Health News:Signet Puerto Rico Leverages PowerServer RIS/PACS/PM™ to Improve Patient Care, Cut Costs 2
... MADISON, N.J., Nov. 8 Wyeth (NYSE: WYE ... Suisse First Boston,Healthcare Conference on Tuesday, November 13, 2007 ... Joseph M. Mahady, Senior Vice President,Wyeth and President, Wyeth ... live for investors at, http://www.wyeth.com and available for ...
... Mutual and Ohio Farm Bureau,Federation (OFBF) have announced ... to OFBF,s more than 230,000 members. Effective ... access to,Medical Mutual,s SuperMed provider network, the most ... providers in Ohio. Medical,Mutual and OFBF have worked ...
... for injury, study finds , THURSDAY, Nov. 8 (HealthDay ... medications may cut their risk for fracture, Canadian researchers ... there,s an increased risk of additional fractures, other health ... in osteoporosis patients are hip, spine, and wrist fractures. ...
... Focusing on his experience as a physician in ... Harris, MD, FACP, president-elect of the American College of ... Committee Subcommittee on Regulations, Healthcare and Trade. , ... financial struggles that Medicare payments to physicians played on ...
... Va. (Nov. 8, 2007) Virginia Commonwealth University researchers ... that play a major role in clotting disorders, which ... the lungs and those localized deep in the body ... occur when the effect of thrombin, a protein involved ...
... Nov. 8 Pathwork Diagnostics, a,genomics-based diagnostics company ... Origin Test is the focus of two studies ... Meeting of the Association,for Molecular Pathology (November 7-10, ... help determine a tumor,s origin so that,tissue-specific management ...
Cached Medicine News:Health News:Ohio Farm Bureau Health Plan Awarded to Medical Mutual of Ohio 2Health News:Ohio Farm Bureau Health Plan Awarded to Medical Mutual of Ohio 3Health News:Sticking With Meds Lowers Elderly Fracture Risk 2Health News:Looming Medicare cuts will disproportionately hurt physicians in small practices 2Health News:Researchers identify molecules with interesting anti-clotting properties 2Health News:Studies Investigate Diagnostic Performance and Reproducibility of Pathwork Diagnostics' Tissue of Origin Test 2Health News:Studies Investigate Diagnostic Performance and Reproducibility of Pathwork Diagnostics' Tissue of Origin Test 3
(Date:9/29/2014)... 29, 2014  On Oct. 2, some 24,000 Lilly ... company,s seventh Global Day of Service. Building on Lilly,s ... together in a single, coordinated effort to improve the ... "I,m so proud of this tradition, and of ... to strengthening the communities around the world where we ...
(Date:9/29/2014)... SANTA ANA, Calif. , Sept. 29, 2014 /PRNewswire/ ... premier supplier of certified child-resistant packaging, accessories and consulting ... that company co-founder Nick Kovacevich has assumed ... Kovacevich, who co-founded the company in 2010 and worked ... company after a brief hiatus focusing on other ventures. ...
(Date:9/29/2014)... N.J. , Sept. 29, 2014  ADM ... that it has entered into an affiliation with ... in Cambridge, Massachusetts founded ... appointed member of ADMT,s Advisory Board. ... medical technology companies with specialized services and finances ...
Breaking Medicine Technology:Lilly's seventh Global Day of Service rallies 24,000 employees in nearly 60 countries 2Lilly's seventh Global Day of Service rallies 24,000 employees in nearly 60 countries 3Kush Bottles Co-Founder Steps into Role of CEO 2ADM Tronics Joins Triotech Ventures Technology Consortium 2ADM Tronics Joins Triotech Ventures Technology Consortium 3
... brightly illuminated hand-held potential vision tester measures ... and glaucoma. Potential vision testing requires ... Meter or RAM (formerly known as the ... Clip (clip with a pinhole disc and ...
... are the latest innovation ... portable battery-powered EEG headboxes. ... new mechanical design, and ... standard MOBEE24plus and MOBEE32 ...
The ACCU-Beam® line of Surgical Microscope Accessories includes digital camera adaptors, beam splitters, objective lenses, fiber optic cables, and fiberoptic retrofits....
The ACCU-Beam® line of Surgical Microscope Accessories includes digital camera adaptors, beam splitters, objective lenses, fiber optic cables, and fiberoptic retrofits....
Medicine Products: