Navigation Links
Gene-Nanoparticle Gene Transfer Is Better Than Viral Vector Transfer System

Nanoparticles can be used in gene therapy to transfer therapeutic genes in to brain cells //and helps in studying genetic mechanism of brain diseases.

Gene-nanoparticle complexes developed by scientists at the University of Buffalo, has proved to deliver therapeutic genes directly into the brains of living mice, the transfer rate is comparatively higher to transfer rates of viral vectors and the procedure does not cause any side effects. The result of this work is published in this week Proceedings of the National Academy of Sciences (PNAS). This procedure is easier and faster in transferring desired genes compared to non-viral vectors which has very low expression and efficacy rates, especially in vivo. This gene nanoparticle complex also helps to study the genetic mechanism of brain diseases in addition to offering repair mechanism.

The scientists used this technique to activate adult brain stem/progenitor cells in vivo, demonstrating that it may be possible to "turn on" these otherwise idle cells as effective replacements for those destroyed by neurodegenerative diseases, such as Parkinson's.

"Until now, no non-viral technique has proven to be as effective as the viral vectors in vivo," said co-author Paras N. Prasad, Ph.D., executive director of the UB Institute for Lasers, Photonics and Biophotonics, SUNY Distinguished Professor in UB's Department of Chemistry and principal investigator of the institute's nanomedicine program. "This transition, from in vitro to in vivo, represents a dramatic leap forward in developing experimental, non-viral techniques to study brain biology and new therapies to address some of the most debilitating human diseases."

Viral vectors for gene therapy always carry with them the potential to revert back to wild-type, and some human trials have even resulted in fatalities. Viral vectors can be produced only by specialists under rigidly controlled laboratory conditions. By contrast, the nanoparti cles developed by the UB team can be synthesized easily in a matter of days by an experienced chemist.

The UB researchers make their nanoparticles from hybrid, organically modified silica (ORMOSIL), the structure and composition of which allow for the development of an extensive library of tailored nanoparticles to target gene therapies for different tissues and cell types and the therapy can be targeted specifically against the desired cells "This is the first time that a non-viral vector has demonstrated efficacy in vivo at levels comparable to a viral vector," Bharali said.

Using a new optical fiber in vivo imaging technique (CellviZio developed by Mauna Kea Technologies of Paris), the UB researchers were able to observe the brain cells expressing genes without having to sacrifice the animal. Using this technique it is also possible to manipulate the behaviour of the brain cells.

(Newswise)



Related Information on Stem cells in Medindia:
Information on stem cells - Stem cells are used to treat degenerative diseases, which occur due to premature cell death or malfunctioning of specific cell type. Stem cells can be used to replace these dead cells.
For more information read:
http://www.medindia.net/patients/
patientinfo/stemcells_about.htm

'"/>




Related medicine news :

1. Free Tissue Transfer Effective in Treating Massive Skin Cancers
2. Tissue Transfer for Skin Cancer
3. Tissue Transfer For Treatment Of Massive Skin Cancers
4. Transfer Of Rabies Virus Possible From Organ Donor To Recipient
5. Decreasing Multiple Births By Single Embryo Transfers
6. Therapeutic Genes Transferred By Viral Vector Through T Cell Masking
7. Biologicals Transfer Proposal between US and Indian Biotechnology
8. Punjabis Transfer Taste From Chicken To Prawns
9. Transplantation Results in CJD Transfer
10. Transfer of NHS hospital care into the community may not save costs
11. Mother Guilty of Transferring HIV to her Child
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to ... app. The fitness app plans to fix the two major problems leading the fitness industry ... fits all type program , They don’t eliminate all the reasons people quit ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Austin residents seeking ... American College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical ... effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
(Date:6/25/2016)... ... 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the ... to iHire in recognition of their exemplary accomplishments in worksite health promotion. , The ... Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one ...
(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... Those ... deal with these feelings, many turn to unhealthy avenues, such as drug or alcohol ... of Marne, Michigan, has released tools for healthy coping following a traumatic event. , ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Bracket , a leading clinical trial technology ... outcomes platform, Bracket eCOA (SM) 6.0, at the 52 ... 30, 2016 in Philadelphia , Pennsylvania.  A ... product of its kind to fully integrate with RTSM, will ... 6.0 is a flexible platform for electronic clinical outcomes assessments ...
(Date:6/23/2016)... Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new ... affiliate in Latin America . ... ... ... ...
(Date:6/23/2016)... June 23, 2016 The vast majority of ... dialysis facility.  Treatments are usually 3 times a week, ... visit, including travel time, equipment preparation and wait time. ... especially grueling for patients who are elderly and frail.  ... nursing and rehabilitation centers for some duration of time. ...
Breaking Medicine Technology: