Navigation Links
Gene Hunters at Johns Hopkins Close In On Lou Gehrig's Disease

In the first genomewide search for the genetic roots of the most common form of amyotrophic lateral sclerosis, Johns Hopkins scientists// have newly identified 34 unique variations in the human genetic code among 276 unrelated subjects with ALS.

The 34 so-called single nucleotide polymorphisms, or SNPs, represent good candidate genes predisposing people to the noninherited form of the fatal neurodegenerative disease.

'Although we haven't located the exact gene responsible for sporadic ALS, our results seriously narrow the search and bring us that much closer to finding what we need to start developing treatments for the disease,' said Bryan J. Traynor, of the Department of Neurology at the School of Medicine.

ALS, also known as Lou Gehrig's disease for the legendary Yankee first baseman who succumbed to its paralyzing assault on the nervous system, kills 10,000 Americans a year. An estimated one in 2,000 people is at risk of developing the disease.

Genes behind inherited forms of ALS--responsible for about only 5 percent of all cases--were discovered a decade ago, but no genetic roots had been found for sporadic ALS, which occurs in people without a family history of the disease.

In the Johns Hopkins study, described in the online version of Lancet Neurology this month, Traynor and his team scanned the entire genome of 276 adult male and female subjects with sporadic ALS and 271 adult male and female subjects with no history of neurological disease.

Researchers used a new technology known as 'SNP chips' to analyze all 555,352 SNPs in the genome of each subject. SNP chips are glass slides that resemble computer processor chips. They're coated with tiny beads that 'read' the SNPs scattered throughout the human genome.

The researchers found 34 genetic variants that ALS patients were more likely to have compared to normal individuals without the disease.

'This is the first major step toward understanding how genetics may influence the most common form of ALS,' said co-researcher Jeffrey D. Rothstein, professor in the Department of Neurology. 'The results will not only help us to better understand sporadic ALS but also to tailor tools that will reveal therapies for it.'

Traynor cautioned that the 34 SNPs are not guaranteed trail markers for ALS genes. 'If you roll dice 555,352 times, you are bound to get lucky by chance alone on some of those throws,' he said. 'The next step is to go back and figure out which of these 'hits' are real and which are false.' Thousands of other SNPs were more weakly associated with ALS, some of which could turn out to be just as important as those more strongly linked.

Traynor says a follow-up study is in the works that will replicate the research using a similar number of patients and controls. Traynor, who has a joint affiliation with the National Institute of Mental Health, collaborated in this study with lead author Jennifer Schymick and fellow researcher John Hardy, both of the Laboratory of Neurogenetics at the National Institute on Aging. Researchers from the National Institutes of Health, the Packard Center for ALS Research at Johns Hopkins and the University of Turin, Italy, also contributed to this study.

This study was supported by funding from the National Institute of Neurological Disorders and Stroke, the Packard Center for ALS Research at Johns Hopkins and the ALS Association.

Source-Eureka Alert
'"/>




Related medicine news :

1. Bird Flu Deters Hunters in Russia
2. Craig Newschaffer of Johns Hopkins Bloomberg School of Public Health in Baltimore.
3. Johns Hopkins Computer Scientists Unravel Language Of Surgery
4. Johns Hopkins Medicine Trustees Support Smoking Ban In Public Spaces
5. Robert Wood Johnson Foundation Pledges $500M To Fund Anti-Obesity Programs
6. Johns Hopkins Begins Aggressive Screening for superbugs in Children
7. John Hopkins CGHH program provides Global Health education
8. A new study by John Hopkins University proposes formula for good health
9. Genetic Experts of Hopkins Assists In Identifying Hurricane Katrina Victims
10. Craig Newschaffer of Johns Hopkins Bloomberg School of Public Health in Baltimore.
11. Diabetes - New Treatment Approach At John Hopkins
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... was developed to enhance the health of felines. The formula is all-natural and is ... herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Austin residents ... the American College of Mohs Surgery and to Dr. Russell Peckham for medical and ... highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed ...
(Date:6/25/2016)... Viejo, California (PRWEB) , ... June 25, 2016 , ... ... to fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... fully customizable and all within Final Cut Pro X . Simply select a ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... As a ... Magna Cum Laude and his M.D from the David Geffen School of Medicine at ... returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the addition of the ... offering. The current unmet ... for MedImmune to enter. The US ageing population creates a ... considerable growth for effective anti-influenza medications. The introduction of a ... development is still in its infancy. Key ...
(Date:6/23/2016)... and BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma ... as the company,s second affiliate in Latin America . ... ... Astellas Farma Colombia ... ...
(Date:6/23/2016)... 2016 Research and Markets has ... Global Analysis (United States, China, Japan, Brazil, United Kingdom, ... their offering. Surgical ... business planners, provides surgical procedure volume data in a ... an in-depth analysis of growth drivers and inhibitors, including ...
Breaking Medicine Technology: