Navigation Links
Gene Discovery Lays Groundwork for Targeted Therapies for Endometrial Cancer

wever they have not been druggable targets," says Pamela Pollock, Ph.D., head of TGen's Melanoma Research Unit. "We are excited about this discovery in that the testing of drugs designed to inhibit this gene in early clinical trials means that we are one step closer to personalized medicine for women with endometrial cancer driven by an altered FGFR2 gene." Pollock spent several years studying the FGFR2 gene in melanoma.

Pollock and Paul Goodfellow, Ph.D., an endometrial cancer expert and professor of surgery, genetics and obstetrics and gynecology at Washington University School of Medicine, are planning additional studies to investigate whether two drugs currently in Phase I trials for other cancers inhibit endometrial cell growth in the laboratory. Future studies include testing these drugs in mouse models of endometrial cancer before testing them in humans.

"We are planning to investigate FGFR2 in tumors from a much larger group of patients to determine whether mutations in the gene lead to aggressive cancers and poor outcome," says Goodfellow, also co-director of the Hereditary Cancer Core at the Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital in St. Louis. "Given how frequent mutations are in endometrial cancers, we are hopeful we will be able to initiate a Phase II trial treating patients with an FGFR2 inhibitor within the next two to three years."

"This study illustrates the power of systematic searches for mutations in cancer genomes in identifying the abnormal genes responsible for driving cancers and providing new therapeutic avenues," says Michael Stratton, M.D., Ph.D., who along with Andrew Futreal, Ph.D., co-leads the Cancer Genome Project at the Wellcome Trust Sanger Institute.

Pollock has studied the FGFR2 gene in melanoma for more than three years. The team headed by Stratton and Futreal at the Cancer Genome Project at the Wellcome Trust Sanger Insti
'"/>




Page: 1 2 3

Related medicine news :

1. Discovery of bone gene
2. New Discovery May Help Treat Infertility
3. New Discovery to Increase Survival of Breast cancer Patients
4. Discovery of World’s smallest laser
5. Discovery of a built-in fat sensor
6. OHSU Researchers Announce New Discovery
7. Discovery Of New Molecule Could Solve Cancer Spread Mystery
8. Discovery Of Human Skeletons Could Unfold Facts About By-Gone Ages
9. New Discovery Shows That Brain Could repair Itself After Stroke
10. New Sleep Gene Discovery Wakes Up Scientists
11. Discovery of Elevated Amyloid Peptide levels could lead to Alzheimer’s Preventio
Post Your Comments:
(Date:7/10/2014)... As the use of electronic health record becomes widespread ... implementation of the Affordable Care Act, the quantity of ... analytic purposes will also dramatically increase. Additionally, experts ... that analyze large quantities of data for the purpose ... the value of patient care a process that ...
(Date:7/10/2014)... (HealthDay News) -- Teens who are sensitive to light ... develop emotional symptoms such as anxiety and depression, a ... that may exacerbate issues teens experience after concussion may ... making decisions about when to return to play and ... study authors Lisa Koehl and Dong Han, of the ...
(Date:7/10/2014)... HealthDay Reporter THURSDAY, July 10, 2014 (HealthDay ... of calorie information on menus, if it,s available, to decide ... study. Women in particular review the menu labeling, said ... the U.S. Centers for Disease Control and Prevention. ... help choose their meal, compared with just under half of ...
(Date:7/10/2014)... captured with a microchip-based device developed at the Massachusetts ... the MGH Cancer Center can be cultured to establish ... In the July 11 issue of Science , ... accurately reflect a tumor,s genetic mutation over time and ... can culture cells from the blood that represent those ...
(Date:7/10/2014)... Human Services (HHS) has announced a three-year grant to ... totaling $4.7 million to support a new national model ... , Titled "Evidence-Conformant Oncology Care," the project will ... care for adult cancer patients with late-stage disease, significant ... , "We believe that the best cancer ...
Breaking Medicine News(10 mins):Health News:Six cases where big data can reduce healthcare costs 2Health News:Six cases where big data can reduce healthcare costs 3Health News:Six cases where big data can reduce healthcare costs 4Health News:Some Teens May Face Emotional Problems After Concussion 2Health News:60 Percent of Diners Use Calorie Labeling When Posted: CDC 2Health News:60 Percent of Diners Use Calorie Labeling When Posted: CDC 3Health News:Cultured CTCs reveal genetic profile, potential drug susceptibility of breast cancer cells 2Health News:Cultured CTCs reveal genetic profile, potential drug susceptibility of breast cancer cells 3Health News:UH Case Medical Center awarded $4.7 million grant from HHS 2Health News:UH Case Medical Center awarded $4.7 million grant from HHS 3
... expert says physicians have unique opportunity to help parents ... ... Washington, DC (Vocus) October 1, ... and their families understand the http://www.childrensnational.org/?utm_source=pressrelease&utm_medium=9_30&utm_campaign=driving_safety [importance of responsible ...
... recent headlines from Wall Street portend tougher times on the horizon, ... smart about their marketing. So says Helmut G. Flasch, of Flasch ... he has shown countless medical professionals how to expand their practices ... ...
... Reduce Claim Fraud and Costs by 30 Percent, ... Euronext: ILO, ISIN: FR0004042364) today announced that Swiss ... is using ILOG,JRules(R) to automate its medical claims ... has been able to reduce,unnecessary medical treatments, provide ...
... the Oct. 1 issue of the journal Sleep ... ideation and attempts, and the use of alcohol, cannabis and ... the presence of insomnia in adolescents increases the risk of ... of these problems. Results indicate that adolescents who had symptoms ...
... , A study conducted by researchers at Mayo Clinic ... enhanced response to the weight loss drug sibutramine, while ... no weight. , The findings are published in the ... , In this randomized, double-blind, placebo-controlled study, Mayo researchers ...
... simple questionnaire can reliably predict whether they will ... Hopkins researchers suggest in a new study. The ... benefit from additional preoperative preparation to ensure they ... exercise, a factor that can greatly affect their ...
Cached Medicine News:Health News:Healthcare Providers Can Help Reduce Teen Driving Deaths 2Health News:Healthcare Providers Can Help Reduce Teen Driving Deaths 3Health News:Medical Marketing Expert Offers Dentists Tips for Thriving Down Economy After the Wall Street Dilemma 2Health News:Medical Marketing Expert Offers Dentists Tips for Thriving Down Economy After the Wall Street Dilemma 3Health News:Swiss Medical Group Selects ILog JRules to Streamline Claims Processing 2Health News:Swiss Medical Group Selects ILog JRules to Streamline Claims Processing 3Health News:Adolescent insomnia linked to depression and substance abuse during adolescence and young adulthood 2Health News:Genes affect weight loss drug effectiveness 2Health News:Will patients stick to physical therapy? Questionnaire can help doctors predict 2Health News:Will patients stick to physical therapy? Questionnaire can help doctors predict 3
(Date:1/15/2014)...  Celsion Corporation (the "Company") (NASDAQ: CLSN ) ... investors to purchase an aggregate of approximately $15 million ... direct offering, led by a dedicated health care fund. ... with these investors pursuant to which the Company agreed ...
(Date:1/15/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ... (OFT) approval condition to the announced tender offer for all of ... As a result of the waiver, the transaction is no longer ... offer on January 24, 2014 following the currently scheduled expiration time, ...
(Date:1/15/2014)... YORK , January 15, 2014 ... Ltd., the exclusive worldwide distributor of highly sophisticated agro-breeding ... on January 7, 2014, the Company,s board of directors ... Weiner as its new member of the board. ...
Breaking Medicine Technology:Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3
MDI will work with your facility to determine the best interim lab to fit your needs and your site....
... 300 ,Oblique 45, ,Type 330 ,Straight, ... by setting the illumination between lenses ... ideal for use in ophthalmology and ... conventional compact microscope can; an advanced ...
... same as the model SP-8800 with one big exception. ... This mode has its own fixation targets to allow ... allows you to select an area on the cornea ... to calculate averages of multiple readings in any one ...
... MedCath is the largest and most experienced ... networks in the United States. Mobile laboratories ... a daily basis, from one hospital to ... geographic area. Each mobile laboratory is fully ...
Medicine Products: