Navigation Links
Gene Discovery Lays Groundwork for Targeted Therapies for Endometrial Cancer

wever they have not been druggable targets," says Pamela Pollock, Ph.D., head of TGen's Melanoma Research Unit. "We are excited about this discovery in that the testing of drugs designed to inhibit this gene in early clinical trials means that we are one step closer to personalized medicine for women with endometrial cancer driven by an altered FGFR2 gene." Pollock spent several years studying the FGFR2 gene in melanoma.

Pollock and Paul Goodfellow, Ph.D., an endometrial cancer expert and professor of surgery, genetics and obstetrics and gynecology at Washington University School of Medicine, are planning additional studies to investigate whether two drugs currently in Phase I trials for other cancers inhibit endometrial cell growth in the laboratory. Future studies include testing these drugs in mouse models of endometrial cancer before testing them in humans.

"We are planning to investigate FGFR2 in tumors from a much larger group of patients to determine whether mutations in the gene lead to aggressive cancers and poor outcome," says Goodfellow, also co-director of the Hereditary Cancer Core at the Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital in St. Louis. "Given how frequent mutations are in endometrial cancers, we are hopeful we will be able to initiate a Phase II trial treating patients with an FGFR2 inhibitor within the next two to three years."

"This study illustrates the power of systematic searches for mutations in cancer genomes in identifying the abnormal genes responsible for driving cancers and providing new therapeutic avenues," says Michael Stratton, M.D., Ph.D., who along with Andrew Futreal, Ph.D., co-leads the Cancer Genome Project at the Wellcome Trust Sanger Institute.

Pollock has studied the FGFR2 gene in melanoma for more than three years. The team headed by Stratton and Futreal at the Cancer Genome Project at the Wellcome Trust Sanger Insti
'"/>




Page: 1 2 3

Related medicine news :

1. Discovery of bone gene
2. New Discovery May Help Treat Infertility
3. New Discovery to Increase Survival of Breast cancer Patients
4. Discovery of World’s smallest laser
5. Discovery of a built-in fat sensor
6. OHSU Researchers Announce New Discovery
7. Discovery Of New Molecule Could Solve Cancer Spread Mystery
8. Discovery Of Human Skeletons Could Unfold Facts About By-Gone Ages
9. New Discovery Shows That Brain Could repair Itself After Stroke
10. New Sleep Gene Discovery Wakes Up Scientists
11. Discovery of Elevated Amyloid Peptide levels could lead to Alzheimer’s Preventio
Post Your Comments:
(Date:4/21/2015)... Dallas, Texas (PRWEB) April 22, 2015 ... Pipeline Review, H1 2015” provides comparative analysis ... The report strengthens R&D pipelines by identifying ... and best-in-class products. Complete report with TOC ... , The report also reviews key players ...
(Date:4/21/2015)... 21, 2015 The joint venture between ... is opening its first freestanding emergency room later this ... and will be licensed under Dignity Health Arizona General ... and Adeptus Health joint venture. , Tim Bricker, President ... Gilbert Medical Centers said the new facility will complement ...
(Date:4/21/2015)... Somerset, NJ & New York, NY (PRWEB) April ... the leading global provider of advanced delivery technologies ... health products, today announced the launch of ADVASEPT™ ... the safe and efficient delivery of injectable medications. ... syringe, combining a safe, convenient and functional container ...
(Date:4/21/2015)... Carinsurancehints.com has released a new blog post ... on auto insurance prices . , Commuting ... Clients should review their insurance options before deciding what ... several forms. Some of the popular policies provide liability, ... online rates and find the best prices in their ...
(Date:4/21/2015)... Colmar, PA (PRWEB) April 21, 2015 ... Ichthyosis & Related Skin Types, Inc.® (FIRST) will publish ... ichthyosis. The campaign will run throughout the month of ... Voice. It Matters to Someone." The positioning was ... about this rare skin disorder and to help support ...
Breaking Medicine News(10 mins):Health News:Pulmonary Embolism Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 2Health News:Pulmonary Embolism Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 3Health News:Pulmonary Embolism Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 4Health News:Dignity Health and Adeptus Health to Open First Freestanding Emergency Room in Chandler, Arizona 2Health News:Dignity Health and Adeptus Health to Open First Freestanding Emergency Room in Chandler, Arizona 3Health News:Catalent Announces the Expansion of its Advanced, Aseptic, Glass-Free Injectable Platform with New ADVASEPT™ Lock Delivery Technology 2Health News:Heavily Circulated Roads Can increase Auto Insurance Costs 2Health News:May is Ichthyosis Awareness Month. Use Your Voice. 2
... Fla., Sept. 15 A most unusual home health care firm is ... they can do. , , When an aging ... often are thrust into their first experience with home health care. Often, ... caregivers simply react to problems, and expectations are low. Her people don,t. ...
... , , PHILADELPHIA, Sept. 15 ... Celebrate Wellness Expo, Saturday, September 19, 11 a.m. to 4 p.m., ... Co-sponsored by The Wellness of You, Inc., and ... will be the presentation of the Tree of Life Award ...
... , MINNEAPOLIS, Sept. 15 ATS ... state-of-the-art cardiac surgery products, announced today that it will participate in ... Hotel in New York. Michael Dale, President and CEO of ... September 22, 2009. , , (Logo: http://www.newscom.com/cgi-bin/prnh/20040202/ATSILOGO ) ...
... have spent ... since 2007 ... campaign contributions , , ... found the industries spent $126,430,438 over the first half of 2009 and $585,725,712 over the past two and a ...
... Sept. 15 /PRNewswire/ - Touch Bionics, developer of the ... that its i-LIMB Hand has won silver in the ... won top honors in the Medical-Devices category. Competition was ... companies from all around the world. , The Wall ...
... , , , ... Certification Commission for Healthcare Information Technology (CCHIT(R)) today announced ... Certified(R) 08 Ambulatory EHR additionally certified for Cardiovascular Medicine ... health record (EHR) criteria for office-based use. Ambulatory EHRs ...
Cached Medicine News:Health News:Seniors May Think They Can't, But They Can 2Health News:The Celebrate Wellness Expo Presents Motivational Speaker & Author Dr. Robin L. Smith and Spiritual Teacher & Author Rev. Michael Bernard Beckwith 2Health News:ATS Medical to Participate at the 2009 UBS Global Life Sciences Conference 2Health News:Insurance and HMO Industries Spend Nearly $700,000 Per Day to Kill Health Care Reform Measures 2Health News:Touch Bionics - Silver Medal Winner of the 2009 Wall Street Journal Technology Innovation Awards 2Health News:gloStream's gloEMR Version 5.0 Receives 08 CCHIT Certification 2Health News:gloStream's gloEMR Version 5.0 Receives 08 CCHIT Certification 3
(Date:4/21/2015)... HICKSVILLE, N.Y. , April 21, 2015  Lincoln ... the local community and the donations keep coming! LCS ... Mom and Dad Alzheimer,s program started by Hebrew Home ... Good Morning Mom and Dad is ... to help Alzheimer,s residents who are sometimes agitated in ...
(Date:4/21/2015)... -- A groundbreaking new, minimally invasive outpatient treatment option ... is now readily available to the estimated 1 million ... who suffer from this condition. ... leading practitioner of this safe, effective, Federal Drug Administration-approved ... new Los Angeles -area medical centers ...
(Date:4/21/2015)... , April 21, 2015   Rock Creek ... development company focused on the treatment of chronic inflammatory ... independent appointment to the Company,s Board of Directors with ... as a new director. ... Rock Creek Pharmaceuticals, said, "Dr. Samuel,s experience in advancing ...
Breaking Medicine Technology:Lincoln Continues Support of the Community: Donates 10 Laptops for Alzheimer's Program 2New Minimally Invasive Treatment for Uterine Fibroids Offers Life-Changing Relief, Without a Hysterectomy, to 1 Million Southern California Women 2New Minimally Invasive Treatment for Uterine Fibroids Offers Life-Changing Relief, Without a Hysterectomy, to 1 Million Southern California Women 3New Minimally Invasive Treatment for Uterine Fibroids Offers Life-Changing Relief, Without a Hysterectomy, to 1 Million Southern California Women 4Rock Creek Pharmaceuticals Appoints New Director and Provides Notice of Settlement of Derivative Litigation 2Rock Creek Pharmaceuticals Appoints New Director and Provides Notice of Settlement of Derivative Litigation 3Rock Creek Pharmaceuticals Appoints New Director and Provides Notice of Settlement of Derivative Litigation 4Rock Creek Pharmaceuticals Appoints New Director and Provides Notice of Settlement of Derivative Litigation 5Rock Creek Pharmaceuticals Appoints New Director and Provides Notice of Settlement of Derivative Litigation 6Rock Creek Pharmaceuticals Appoints New Director and Provides Notice of Settlement of Derivative Litigation 7
... , SAN DIEGO, Oct. 15 Prometheus Laboratories ... announced the nationwide commercial launch of three new ... Dx and ProOnc Mesothelioma Dx. Each of these ... microRNA technology. , "Prometheus has a long and ...
... HOLLYWOOD, Fla. and PRINCETON, N.J., Oct. 15 ... preclinical and pharmaceutical product development services and PharmaNet ... development services to innovative pharmaceutical, biotechnology, generic drug ... the completion of a business development and co-promotion ...
Cached Medicine Technology:Prometheus Launches ProOnc Dx Cancer Diagnostics 2Prometheus Launches ProOnc Dx Cancer Diagnostics 3Azopharma and PharmaNet Development Group Enter Preclinical Strategic Alliance 2
250L...
250L...
... Pipette is a synonym for pipetting accuracy, ... design, and superior operating comfort. Its single, ... measuring stroke and blow-out as well as ... ensures utmost accuracy and precision. Ejection sleeve ...
Pipetman F is a fixed-volume, air-displacement pipette. Thirteen robust models cover a large volume range from 2 L to 1000 L, with Gilsons legendary accuracy and precision....
Medicine Products: