Navigation Links
Gene Discovery Lays Groundwork for Targeted Therapies for Endometrial Cancer

Discovery of alterations in a gene called FGFR2 could accelerate the development of new treatments for endometrial cancer, a type of uterine cancer. Researchers at Washington University School of Medicine in St. Louis; the Translational Genomics Research Institute (TGen); the Wellcome Trust Sanger Institute, which is part of Cambridge University; and New York University School of Medicine reported the findings in the May 21, 2007, online version of the journal Oncogene.

The mutations in FGFR2 were found in a subset of endometrial cancers, the most common gynecologic cancer in the United States. The genetic changes result in uncontrolled cell division, a hallmark of cancer. Drugs already in clinical trials inhibit FGFR2 function and could potentially lead to new treatments for endometrial cancers, according to the researchers.

Nearly 40,000 women are diagnosed with endometrial cancer each year, making it the fourth most common cancer found in women, following breast cancer, lung cancer and colon cancer. Endometrial cancer usually begins in the lining of the uterus and is most commonly found in women between the ages of 60 and 70. If discovered early, this slow-growing cancer can be successfully treated by surgical removal of the uterus. However, about 7,000 women die each year from the more aggressive form of endometrial cancer.

Researchers used the latest genome-scanning technology to sequence 187 endometrial tumor samples. The research team identified mutations in FGFR2 in 16 percent of tumors that represented a specific subset of endometrial cancer. The other types of endometrial cancer did not have these mutations. The FGFR2 gene encodes a protein that plays a critical role in cell growth. In patients with FGFR2 mutations, the tumors were caused by the receptor for this protein being permanently stuck in the "on" position.

"Mutations in several genes have previously been identified in endometrial cancer, ho wever they have not been druggable targets," says Pamela Pollock, Ph.D., head of TGen's Melanoma Research Unit. "We are excited about this discovery in that the testing of drugs designed to inhibit this gene in early clinical trials means that we are one step closer to personalized medicine for women with endometrial cancer driven by an altered FGFR2 gene." Pollock spent several years studying the FGFR2 gene in melanoma.

Pollock and Paul Goodfellow, Ph.D., an endometrial cancer expert and professor of surgery, genetics and obstetrics and gynecology at Washington University School of Medicine, are planning additional studies to investigate whether two drugs currently in Phase I trials for other cancers inhibit endometrial cell growth in the laboratory. Future studies include testing these drugs in mouse models of endometrial cancer before testing them in humans.

"We are planning to investigate FGFR2 in tumors from a much larger group of patients to determine whether mutations in the gene lead to aggressive cancers and poor outcome," says Goodfellow, also co-director of the Hereditary Cancer Core at the Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital in St. Louis. "Given how frequent mutations are in endometrial cancers, we are hopeful we will be able to initiate a Phase II trial treating patients with an FGFR2 inhibitor within the next two to three years."

"This study illustrates the power of systematic searches for mutations in cancer genomes in identifying the abnormal genes responsible for driving cancers and providing new therapeutic avenues," says Michael Stratton, M.D., Ph.D., who along with Andrew Futreal, Ph.D., co-leads the Cancer Genome Project at the Wellcome Trust Sanger Institute.

Pollock has studied the FGFR2 gene in melanoma for more than three years. The team headed by Stratton and Futreal at the Cancer Genome Project at the Wellcome Trust Sanger Insti tute found preliminary data hinting that FGFR2 might play an important role in endometrial cancer. Pollock then established a collaboration with Goodfellow, who provided tumor samples representative of the different types of uterine cancers as well as a wealth of expertise on endometrial cancer.


Related medicine news :

1. Discovery of bone gene
2. New Discovery May Help Treat Infertility
3. New Discovery to Increase Survival of Breast cancer Patients
4. Discovery of World’s smallest laser
5. Discovery of a built-in fat sensor
6. OHSU Researchers Announce New Discovery
7. Discovery Of New Molecule Could Solve Cancer Spread Mystery
8. Discovery Of Human Skeletons Could Unfold Facts About By-Gone Ages
9. New Discovery Shows That Brain Could repair Itself After Stroke
10. New Sleep Gene Discovery Wakes Up Scientists
11. Discovery of Elevated Amyloid Peptide levels could lead to Alzheimer’s Preventio
Post Your Comments:

(Date:11/28/2015)... ... , ... Trying to relax on a couch can actually be uncomfortable, so ... design due to personal experience with a bad back," he said. , This easy-to-use, ... well as increases support. It also makes it easier to eat, do other activities ...
(Date:11/27/2015)... Canada (PRWEB) , ... November 28, 2015 , ... There ... do we outperform our billings from last year? , This question has not been ... organizations are coming to the retirement age and the younger workforce don’t share the ...
(Date:11/27/2015)... ... ... According to an article published November 15th by ABC News, ... in light of the recent terrorist attacks in Paris, other cities are taking extra ... from reaching U.S. soil. Especially around special events that may be high-profile in nature, ...
(Date:11/27/2015)... ... November 27, 2015 , ... An inventor, from ... dispense prescription medications at home, so he invented the patent-pending ELECTRONIC M.D. , ... prescription medications. In doing so, it could help to prevent potential overdose situations. ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... edition of USA Today in Atlanta, Dallas, New York, Minneapolis, South Florida, with ... digital component is distributed nationally, through a vast social media strategy and across ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... Pays-Bas, November 27, 2015 ... traitement photodynamique au Bremachlorin contre le cancer avancé. ... consistant à combiner l,immunothérapie au traitement photodynamique au ... --> Une nouvelle approche consistant à ... le cancer avancé.    Clinical ...
(Date:11/27/2015)... DUBLIN , Nov. 27, 2015 Research ... of the "Global Intrauterine Devices Market 2015-2019" ... --> In this report, the author ... intrauterine devices market for 2015-2019. To calculate the market ... of following type of products: Hormonal IUDs and copper ...
(Date:11/26/2015)... , 26 november 2015 AAIPharma ... de geplande investering aan van ten minste ... laboratoria en het mondiale hoofdkantoor in ... zal resulteren in extra kantoorruimte en extra ... de groeiende behoeften van de farmaceutische en ...
Breaking Medicine Technology: