Navigation Links
Gene Defects Determine Susceptibility to Cancer and Bone Marrow Failure

A new study has now highlighted that certain gene defects that control of protein synthesis can either increase or decrease an individual's susceptibility to cancer and other diseases. //Surprisingly, such genetic mechanisms can be responsible for cancer although the protein levels are normal, reveals the study that has been published in the journal, Science.

Directed by molecular biologist Davide Ruggero, Ph.D., of Fox Chase Cancer Center's human genetics program, the study attributed the protein defects to a critical glitch in the protein assembly line of ribosomes. This highlights the importance of proteomic research analyzing proteins.

‘While defects in a number of genes are known to lead to cancer and disease, this opens up a new avenue of research,’ Ruggero said. ‘The DNA may be fine, but now we see another means by which the product it encodes can become defective.’

Until now, little has been known about how disease may result from abnormal ribosomes--the protein factories of cells, which use RNA to translate the DNA blueprint into functional proteins. Ruggero's laboratory focuses on understanding control of ribosome activity and how disruptions in RNA translation predispose people to cancer.

His new study shows that specific defects in RNA translation underlie a progressive disease called dyskeratosis congenita. It involves multiple organ systems and includes premature aging and increased susceptibility to cancer. The disease results from a gene mutation, Dkc1, that affects ribosome function.

Dyskeratosis congenita involves abnormal bone marrow leading to anemia, immune deficiency and infections; increased risk of various cancers, including lymphoma; and, starting as early as age 10, abnormalities of skin, nails and mucous membranes that resemble premature aging syndromes. The majority of patients are male.

The Fox Chase researchers used a variety of approaches to study the Dkc1 mutation in cells f
'"/>




Page: 1 2

Related medicine news :

1. IVF technique May Increase The Risk Of Birth Defects
2. Epilepsy Drugs Can Enhance Risk of Birth Defects
3. Fortifying Foods Found To Reduce Birth Defects
4. Making Fortification Mandatory In Order To Reduce Birth Defects
5. Birth Defects Caused By Drugs Used For Epilepsy
6. Birth Defects Caused By Acne Medication Can Be Minimized By Voluntary Pregnancy Prevention
7. Addition Of Folic Acid In Flour Proposed To Arrest Birth Defects In The UK
8. Risk Of Birth Defects Slightly Increased Due To IVF
9. Risk Of Birth Defects Increased Due To Anti-Depressant Medication
10. Folic Acid Improves Survival Rate Of Children With Birth Defects
11. Birth Defects Caused By Deficiencies In Cell Signaling Pathway
Post Your Comments:
(Date:9/3/2015)... ... , ... Dr. Robert Winchell has been appointed director of the Trauma Center ... Cornell Medical Center, effective July 27. He will serve on the faculty of Weill ... the critically injured and the development, design and operations of trauma systems. As chief, ...
(Date:9/3/2015)... ... September 03, 2015 , ... Atlantic Information Services, Inc. (AIS) ... Benefit Strategies for a Rapidly Changing Marketplace.” In this Sept. 16 program, pharmacy ... discuss how plan sponsors are adopting bold, innovative strategies to control soaring specialty ...
(Date:9/3/2015)... CA (PRWEB) , ... September 03, 2015 , ... ProScrub ... easily create back & forth, flicker, repeat, and custom speed effects without the use ... and the speed of effect. ProScrub tools are perfect complements to energetic video ...
(Date:9/3/2015)... ... September 03, 2015 , ... “Love in Tokyo” an independent romantic ... , and Amazon and will be released on DVD early next year, ... a Foreigner,” Itsuka, an actress and singer/songwriter, and Jason London, lead from “Dazed and ...
(Date:9/3/2015)... WI (PRWEB) , ... September 03, 2015 , ... At ... after becoming dissatisfied with the traditional health care model, where the primary care physician ... of individuals who want to become educated about their health issues and empowered to ...
Breaking Medicine News(10 mins):Health News:Trauma Expert Joins NewYork-Presbyterian Hospital and Weill Cornell Medical College 2Health News:Trauma Expert Joins NewYork-Presbyterian Hospital and Weill Cornell Medical College 3Health News:Trauma Expert Joins NewYork-Presbyterian Hospital and Weill Cornell Medical College 4Health News:Trauma Expert Joins NewYork-Presbyterian Hospital and Weill Cornell Medical College 5Health News:Speakers for Upcoming AIS Virtual Conference on Pharmacy Benefit Strategies Include Executives from CVS Health, Express Scripts 2Health News:FCPX Effects Developer Releases ProScrub for Final Cut Pro X 2Health News:The Romantic Comedy Film "Love in Tokyo" Has Been Released on ITunes, Google Play, and Amazon 2Health News:Men Dissatisfied with the Primary Care Physician’s Approach to Andropause Are Turning to Renew Man™ 2Health News:Men Dissatisfied with the Primary Care Physician’s Approach to Andropause Are Turning to Renew Man™ 3
... Diabetes Will Meet Nick Jonas in Los Angeles and,Become ... N.Y., Oct. 30 To kick off Diabetes Awareness,Month, ... have,won the opportunity to meet teen pop sensation Nick ... In Nick,s Shoes" (W.I.N.S.),sweepstakes. These Grand Prize winners will ...
... last Sunday in March increases the risk of myocardial infarction ... in the autumn reduces the risk, albeit to a lesser ... the prestigious New England Journal of Medicine . , ... myocardial infarction in Sweden has changed with the summer and ...
... off American,Diabetes Month this November, the American Diabetes ... along with Eli,Lilly and Company,s national educational initiative, ... Update, an educational program for people affected by ... November 1, at the Greater,Grace Temple, 23500 W. ...
... Resource for Sharing Product, Educational Expertise,with ASCs, ... Braun Medical Inc. (B.,Braun) has launched a ... educational and editorial information for ambulatory surgical ... The new online resource, http://www.asc.bbraunusa.com, ...
... First Company to Reach Pivotal Study for Spine Nucleus ... Technology,Inc. announced today, the U.S. Food and Drug Administration ... the NuBac(R) Nucleus,Replacement Device for the spine., Pioneer,s ... MD, MBA,says, "This is a huge milestone and accomplishment ...
... Therapeutics,Inc. (OTC Bulletin Board: ARNI.OB), a clinical-stage biopharmaceutical,company ... William F. Hamilton, Ph.D. to its Board of ... Hamilton has over 40 years experience as a,professor ... the areas of,technology strategy and planning, entrepreneurship and ...
Cached Medicine News:Health News:Bayer Diabetes Care Names 'Walk In Nick's Shoes' (W.I.N.S.) Sweepstakes Grand Prize Winners 2Health News:Bayer Diabetes Care Names 'Walk In Nick's Shoes' (W.I.N.S.) Sweepstakes Grand Prize Winners 3Health News:Clock-shifts affect risk of heart attack 2Health News:American Diabetes Association and Eli Lilly and Company Unite to Educate and Empower African-Americans with Diabetes 2Health News:American Diabetes Association and Eli Lilly and Company Unite to Educate and Empower African-Americans with Diabetes 3Health News:B. Braun Medical Inc. Launches Ambulatory Surgical Center Website 2Health News:Pioneer(R) Surgical Technology's NuBac(R) Nucleus Replacement Device Wins FDA Approval for IDE Pivotal Study 2Health News:Pioneer(R) Surgical Technology's NuBac(R) Nucleus Replacement Device Wins FDA Approval for IDE Pivotal Study 3Health News:Arno Therapeutics Appoints William F. Hamilton to Board of Directors 2Health News:Arno Therapeutics Appoints William F. Hamilton to Board of Directors 3
(Date:9/2/2015)... 2, 2015 The quantum dot market report analyzes ... market based on the product includes medical devices, display, and ... lighting, battery and energy storage, QD laser, and transistor. The ... the quantum dot market. The report also provides the geographic ... , Europe , Asia-Pacific ...
(Date:9/2/2015)... YORK , Sept. 2, 2015   About ... the most common laboratory technologies that is used for ... antibodies in solution. ELISA test uses various types of ... phosphatases and the result is detected by photometry or ... the treatment of various infectious diseases such as HIV, ...
(Date:9/2/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/l8z67c/pharmaceutical ) has announced the ... Switzerland - November 26-27, 2015)" conference to their offering. ... of the key areas of pharmaceutical regulatory affairs in ... Macau and Taiwan ... aspects of gaining and maintaining a successful Marketing Authorisation in ...
Breaking Medicine Technology:Quantum Dot Market by Product , Material, Application, and Geography- Forecast up to 2020 2Global Enzyme-Linked Immunosorbent Assay (Elisa) Testing Market 2015-2019 2Global Enzyme-Linked Immunosorbent Assay (Elisa) Testing Market 2015-2019 3Pharmaceutical Regulatory Affairs in China Seminar: Basel, Switzerland - November 26-27, 2015 2
... Feb. 14, 2011 McNicoll, Lewis & Vlak LLC ... industries, announced today that Caroline Corner, Ph. D. has ... where she will cover the Medical Devices and Diagnostics ... (Logo: http://photos.prnewswire.com/prnh/20100920/NY67927LOGO) "The addition of ...
... HILL, N.C., Feb. 14, 2011 Thought Leader Select, ... the biopharmaceutical industry and the medical community, announces the ... blog Marketing4Health . The research ... to become the blog,s exclusive sponsor, beginning ...
Cached Medicine Technology:Medical Devices and Diagnostics Analyst Joins MLV to Further Expand its Coverage of the Life Sciences Sector 2Thought Leader Select Announces Media Partnership with Marketing4Health 2
... Units With Titanium Staples for use with ... Titanium Staples)., ,The Auto Suture™ MULTIFIRE ... staplers with MULTIFIRE GIA™ 60 and 80 ... Suture™ MULTIFIRE SGIA™ 60 knifeless single use ...
... The PROXIMATE HCS Procedure for Prolapse and ... of titanium staples in 33mm diameter size. ... canal for transection and resection of internal ... surgical treatment of hemorrhoidal disease. The PPH01 ...
... ILS Staplers are anastomotic staplers available in ... instrument to lumen diameter. The staplers permit ... to improve access and ease of use. ... tissue compression by adjusting the height of ...
ENDOPATH ILS Circular Sizer Set for ILS circular staplers. , ,The ILS Circular Sizer Set is intended to aid in selecting the appropriate size ILS Intraluminal Stapler for use in a variety of applica...
Medicine Products: