Navigation Links
Gene Activity connected to Schizophrenia

Two new studies have identified genetic activity that appears to be associated with schizophrenia, a serious brain disorder that alters a person's perceptions of reality, emotions and thought processes. Symptoms of the disorder, which affects about 1% of the world's population, typically surface during the late teens and 20s.In this study, Dr. Maria Karayiorgou of Rockefeller, University in New York and colleagues identified two genes/// located in a region of chromosome 22--a section of DNA that has previously been linked to schizophrenia--that appeared to play a role in the disease.

In their study, Karayiorgou's team analyzed DNA samples from more than 250 people with schizophrenia, their parents and a group of healthy individuals. The researchers included people with childhood onset schizophrenia, a rare form of the disease that strikes by age 12.

The two genes are PRODH2, which encodes for a common brain enzyme, and DGCR6, a gene that is associated with nervous system development. Certain variations in the PRODH2 seemed to be more common in those with schizophrenia than in others, although the investigators could not rule out nearby DGCR6 as playing a role.

Karayiorgou felt that variation in the genes was over-represented in the patients with schizophrenia compared to the healthy people. More work is needed until we have a genetic profile of variation that could account for the schizophrenia in any given person. The researchers honed in on chromosome 22 because people who have deletions or damage in this portion of DNA are known to have a 30-fold greater risk of developing schizophrenia, she said.

In the second study, Sabine Bahn of the Babraham Institute in Cambridge, UK, and colleagues also identified genes on chromosome 22 that they believe may play a role in schizophrenia.

The team analyzed brain tissue from dead schizophrenia patients and compared them with similar samples from those with other psychiat ric patients and healthy individuals. Patients with schizophrenia had nearly three times the gene expression of apolipoprotein L1, a protein that is manufactured by a family of genes called the apo L family. These genes play an important role in cholesterol transport. Cholesterol is important in the adult brain as well as during its early development.

The findings led the researchers to conclude that it is best to be confident in suggesting that abnormalities in the expression of these genes may be involved in the genesis of schizophrenia.


Related medicine news :

1. Restricted Activity Predicts Disability
2. Do Asthma Sufferers Lack Physical Activity?
3. Midlife Brain Activity a Predictor Of Alzheimer’s Diseas
4. Asthma Sufferers Lacking Physical Activity
5. Activity Found To Improve Sleep In The Elderly
6. Physical Activity Good For Developing Cognitive Skills
7. The Consequences Of Stopping Physical Activity
8. Physical Activity During Leisure Can Reduce Risk Of Stroke
9. New Technique To Detect Activity Of Drugs In The Body
10. Women With Anorexia Have Altered Brain Activity
11. Cervical Cancer Vaccine Twice As Effective Before Onset Of Sexual Activity
Post Your Comments:

(Date:10/13/2017)... , ... October 13, 2017 , ... ... be giving viewers the lowdown on sciatica in a new episode of "Success ... focuses on current events and innovation and investigates each subject in-depth with passion ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “America On The ... identity. “America On The Brink” is the creation of published author, William Nowers. ... great-grandchildren. As a WWII veteran, he spent thirty years in the Navy. ...
(Date:10/12/2017)... Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... centers in the U.S., announced today its plans to open a flagship location in ... will occupy the former Rooms To Go store next to Office Depot in the ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of ... Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, ... In honor of Morris F. Collen, a pioneer in the field of medical informatics, ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... Hair Restoration, has recently contributed a medical article to the newly revamped ... Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular Unit ...
Breaking Medicine News(10 mins):
(Date:9/12/2017)... and NEW YORK , Sept. 12, 2017   ... for global supply chains, has published the first annual edition of its ... of more than 20,400 companies evaluated by EcoVadis, based on Scorecard Ratings ... 2016. ... CSR Risk & Performance Index ...
(Date:9/12/2017)... , Sept. 12, 2017  ValGenesis Inc., the ... (VLMS), is pleased to announce the appointment of ... of its Board of Directors and Chairman of ... enables life science companies to manage their entire ... of paper in this process. Furthermore, ValGenesis VLMS ...
(Date:9/9/2017)... , Sept. 8, 2017 Dealmed Medical Supplies, ... supplier of medical equipment, supplies, drugs, vaccines, and specialty ... entered into an agreement to acquire Vantage Medical Supplies, ... in Holtsville, New York . ... supplying new and emerging medical practices, will operate under ...
Breaking Medicine Technology: