Navigation Links
Gene Activity connected to Schizophrenia

Two new studies have identified genetic activity that appears to be associated with schizophrenia, a serious brain disorder that alters a person's perceptions of reality, emotions and thought processes. Symptoms of the disorder, which affects about 1% of the world's population, typically surface during the late teens and 20s.In this study, Dr. Maria Karayiorgou of Rockefeller, University in New York and colleagues identified two genes/// located in a region of chromosome 22--a section of DNA that has previously been linked to schizophrenia--that appeared to play a role in the disease.

In their study, Karayiorgou's team analyzed DNA samples from more than 250 people with schizophrenia, their parents and a group of healthy individuals. The researchers included people with childhood onset schizophrenia, a rare form of the disease that strikes by age 12.

The two genes are PRODH2, which encodes for a common brain enzyme, and DGCR6, a gene that is associated with nervous system development. Certain variations in the PRODH2 seemed to be more common in those with schizophrenia than in others, although the investigators could not rule out nearby DGCR6 as playing a role.

Karayiorgou felt that variation in the genes was over-represented in the patients with schizophrenia compared to the healthy people. More work is needed until we have a genetic profile of variation that could account for the schizophrenia in any given person. The researchers honed in on chromosome 22 because people who have deletions or damage in this portion of DNA are known to have a 30-fold greater risk of developing schizophrenia, she said.

In the second study, Sabine Bahn of the Babraham Institute in Cambridge, UK, and colleagues also identified genes on chromosome 22 that they believe may play a role in schizophrenia.

The team analyzed brain tissue from dead schizophrenia patients and compared them with similar samples from those with other psychiat ric patients and healthy individuals. Patients with schizophrenia had nearly three times the gene expression of apolipoprotein L1, a protein that is manufactured by a family of genes called the apo L family. These genes play an important role in cholesterol transport. Cholesterol is important in the adult brain as well as during its early development.

The findings led the researchers to conclude that it is best to be confident in suggesting that abnormalities in the expression of these genes may be involved in the genesis of schizophrenia.


'"/>




Related medicine news :

1. Restricted Activity Predicts Disability
2. Do Asthma Sufferers Lack Physical Activity?
3. Midlife Brain Activity a Predictor Of Alzheimer’s Diseas
4. Asthma Sufferers Lacking Physical Activity
5. Activity Found To Improve Sleep In The Elderly
6. Physical Activity Good For Developing Cognitive Skills
7. The Consequences Of Stopping Physical Activity
8. Physical Activity During Leisure Can Reduce Risk Of Stroke
9. New Technique To Detect Activity Of Drugs In The Body
10. Women With Anorexia Have Altered Brain Activity
11. Cervical Cancer Vaccine Twice As Effective Before Onset Of Sexual Activity
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/14/2018)... (PRWEB) , ... December 14, 2018 , ... Art of ... of Dentistry, are helping patients in La Mesa, CA interested in cosmetic dentistry and ... individuals whose teeth and gums are not aesthetically appealing because of decay, damage, or ...
(Date:12/13/2018)... ... 2018 , ... Dr. Daniel Careaga, prestigious plastic surgeon of ... Network, well known for their exclusivity, and luxurious lifestyle publication is privileged to ... the Haute Living partnership. , Dr. Careaga has performed over 8,000 successful ...
(Date:12/13/2018)... ... December 13, 2018 , ... ... regenerative and anti-aging practice. Dr. Haake is currently accepting new patients for hormone ... Family Medicine by the American Board of Osteopathic Medicine. A Diplomat of the ...
(Date:12/13/2018)... ... 13, 2018 , ... Shady Grove Fertility (SGF) ... team, seeing patients at SGF’s Woodbridge, VA location. Dr. Swelstad will ... treatment options for female and male infertility, as well as elective fertility preservation, ...
(Date:12/13/2018)... , ... December 13, 2018 , ... ... Vice President of Consultant Engagement. Beth brings over 20 years of leadership experience ... Evergreen. Beth is passionate about building strong teams and creating vibrant cultures of ...
Breaking Medicine News(10 mins):
(Date:12/13/2018)... ... December 13, 2018 , ... Triple W, an ... of DFree ®, the first wearable device for urinary incontinence. DFree ... care agencies, to help manage the care of patients with bladder control issues. ...
(Date:12/10/2018)... ... December 10, 2018 , ... Over the years, Eye Institute of New York ... range of services, and personalized care. The affiliation with OCLI will allow the office ... New York recently became the sixth affiliation of Spectrum Vision Partners’ managed practices since ...
(Date:12/8/2018)... ... 2018 , ... Nationally, it is estimated that 114 million people have no ... seriously lacking and make it challenging to get needed care. Local Pleasant Hill, ... accessible and affordable to everyone, with or without dental insurance. The solution is ...
Breaking Medicine Technology: