Navigation Links
Gene Activity connected to Schizophrenia

Two new studies have identified genetic activity that appears to be associated with schizophrenia, a serious brain disorder that alters a person's perceptions of reality, emotions and thought processes. Symptoms of the disorder, which affects about 1% of the world's population, typically surface during the late teens and 20s.In this study, Dr. Maria Karayiorgou of Rockefeller, University in New York and colleagues identified two genes/// located in a region of chromosome 22--a section of DNA that has previously been linked to schizophrenia--that appeared to play a role in the disease.

In their study, Karayiorgou's team analyzed DNA samples from more than 250 people with schizophrenia, their parents and a group of healthy individuals. The researchers included people with childhood onset schizophrenia, a rare form of the disease that strikes by age 12.

The two genes are PRODH2, which encodes for a common brain enzyme, and DGCR6, a gene that is associated with nervous system development. Certain variations in the PRODH2 seemed to be more common in those with schizophrenia than in others, although the investigators could not rule out nearby DGCR6 as playing a role.

Karayiorgou felt that variation in the genes was over-represented in the patients with schizophrenia compared to the healthy people. More work is needed until we have a genetic profile of variation that could account for the schizophrenia in any given person. The researchers honed in on chromosome 22 because people who have deletions or damage in this portion of DNA are known to have a 30-fold greater risk of developing schizophrenia, she said.

In the second study, Sabine Bahn of the Babraham Institute in Cambridge, UK, and colleagues also identified genes on chromosome 22 that they believe may play a role in schizophrenia.

The team analyzed brain tissue from dead schizophrenia patients and compared them with similar samples from those with other psychiat ric patients and healthy individuals. Patients with schizophrenia had nearly three times the gene expression of apolipoprotein L1, a protein that is manufactured by a family of genes called the apo L family. These genes play an important role in cholesterol transport. Cholesterol is important in the adult brain as well as during its early development.

The findings led the researchers to conclude that it is best to be confident in suggesting that abnormalities in the expression of these genes may be involved in the genesis of schizophrenia.


'"/>




Related medicine news :

1. Restricted Activity Predicts Disability
2. Do Asthma Sufferers Lack Physical Activity?
3. Midlife Brain Activity a Predictor Of Alzheimer’s Diseas
4. Asthma Sufferers Lacking Physical Activity
5. Activity Found To Improve Sleep In The Elderly
6. Physical Activity Good For Developing Cognitive Skills
7. The Consequences Of Stopping Physical Activity
8. Physical Activity During Leisure Can Reduce Risk Of Stroke
9. New Technique To Detect Activity Of Drugs In The Body
10. Women With Anorexia Have Altered Brain Activity
11. Cervical Cancer Vaccine Twice As Effective Before Onset Of Sexual Activity
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2017)... ... 2017 , ... “Code Word: Chocolate Biscuit”: a biographical account following a man who went on ... of published author, Marlyn Ivey, born in Lynn Haven, Florida and at the age of ... 19 years of age, he joined the Navy and got married right out of boot ...
(Date:1/20/2017)... ... 20, 2017 , ... D R Burton Healthcare Products LLC, ... featured in a study indicating superior performance against competitive products in secretion clearance. ... Oscillating Positive Expiratory Pressure Devices During Simulated Breathing“ was published in the winter ...
(Date:1/20/2017)... ... ... enchanting tale that teaches children the true meaning of Christmas. “Journey to Christmas” is the ... devoted woman of faith. , “Becoming a parent changes you. In my case, the ... years, but actually doing it might have been a while in coming if it hadn’t ...
(Date:1/20/2017)... ... , ... “The Land of More and More”: a brilliant story for ... shares the simple and achievable answer. “The Land of More and More” is the ... Church in Angola, Indiana where he works with the children’s ministry department. , ...
(Date:1/19/2017)... ... 2017 , ... Today, the Centers for Medicare & Medicaid Services (CMS) announced ... Models (APMs) in 2017. Clinicians who participate in APMs are paid for the quality ... the Administration’s effort to build a system that delivers better care and one in ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... Research and Markets has announced the addition of the ... Amplifiers, Diagnostic Instruments), Sales Volume, Company Analysis and Forecast to ... ... Volume, Company Analysis and Forecast to 2022 provides a comprehensive ... The growing prevalence of hearing impairment coupled with an expanding ...
(Date:1/20/2017)... , Jan. 20, 2017  Palladian Health, ... has announced the launch of an opioid management ... guidelines on opioids and helps stem the growing ... often prescribed to treat chronic non-cancer pain (back ... serious risks and lack of evidence regarding long-term ...
(Date:1/19/2017)... 2017 Germany Cataract Surgery ... new report, "Germany Cataract Surgery Devices Market Outlook to ... Surgery Devices market. The report provides value, in millions ... (USD) within market segements - Phacoemulsification Equipment and Ophthalmic ... shares and distribution shares data for each of these ...
Breaking Medicine Technology: