Navigation Links
Gender Linked to Development of Skin Cancer

Inherent gender differences – instead of more sun exposure – may be one reason why men are three times more likely than women to develop certain kinds of skin cancer// , say researchers at Ohio State University Medical Center.

Squamous cell carcinoma is the second most common form of skin cancer, accounting for nearly 200,000 new cases in the United States each year. While occurring more often than melanoma, squamous cell carcinoma is not nearly as worrisome. Still, it can be lethal in some patients, especially those with suppressed immune systems, including transplant recipients or people who are HIV-positive.

Many studies have shown that the risk of squamous cell carcinoma increases with greater exposure to the sun. For years, investigators assumed that lifestyle had a lot to do with the disparity in the incidence of SCC – believing that men spend more time outside and are less likely to use sun protection than women.

While that may be true, scientists at Ohio State have shown that there may be another, even more critical factor involved – gender-linked differences in the amount of naturally occurring antioxidants in the skin.

The study appears in the April 1 issue of Cancer Research.

Dr. Tatiana Oberyszyn, an assistant professor of pathology and of molecular virology, immunology and medical genetics at Ohio State University Medical Center, has been studying non-melanoma skin cancers for years. She had a hunch there might be gender-related variables that accounted for the difference between male and female rates of developing these malignancies, and designed an experiment to find out what they might be.

A doctoral student in Oberyszyn’s laboratory, Jennifer Thomas-Ahner, subjected male and female mice to a single, identical, acute exposure to UVB light. It is UVB rays, as opposed to UVA or UVC rays in sunlight, that cause the most damage to the skin. Even a single, prolonged exposure is enough to cause inflammation (sunburn) and its attendant redness, swelling and increased vascular flow.

Thomas-Ahner compared various measures of the inflammatory response in the male and female groups, noting the degree of swelling, antioxidant levels, DNA damage in the skin and the levels of myeloperoxidase in the tissue.

Myeloperoxidase is an enzyme that reflects the extent of neutrophil infiltration, the first step in the inflammatory response. Antioxidants help repair damaged DNA and also help clean up toxic byproducts of injured tissue.

She discovered significant differences between the two groups. The male mice registered a weaker inflammatory response than did the females, as measured by the thickness of their skin and myeloperoxidase levels. They also had more extensive DNA damage in their skin and lower antioxidant levels in their skin than the females.

In a second experiment, Thomas-Ahner exposed male and female mice to longer, chronic sun exposure, irradiating them three times weekly for 16 weeks. When the mice were 25 weeks old, she examined them for differences in tumor growth, size and number.

She found that male mice developed tumors earlier and had more tumors than did female mice. The tumors in the male mice also tended to be larger and more aggressive than were those in the female mice.

Oberyszyn and Thomas-Ahner also noted that the difference in the antioxidant capacity between male and female mice was present in the untreated skin as well as the treated skin. Oberyszyn, a member of the Ohio State University Comprehensive Cancer Center, believes that the greater amount of naturally occurring antioxidant capacity in the females accounted for their ability to thwart a certain degree of tumor growth and spread.

"This is the first time anyone has ever looked at the effect of gender on the development of UVB-induced skin cancers in such a controlled environment," says Oberyszy n. "It’s given us clear evidence of a biological basis for the gender bias in developing squamous cell carcinoma."

Oberyszyn says other studies need to be done to validate the findings, but noted the data are compatible with other studies suggesting a potential biological basis for gender difference in the development of cancer and other diseases.

Source-EurekalertSRM
'"/>




Related medicine news :

1. Insulin Resistance Linked To Difference In Gender
2. Gender difference in Pain Experience - Women feel More Pain than men
3. Imbalance In Gender Ratio Addressed By Religious Leaders
4. Renuka Chowdhury Stresses Importance of Bridging Gender Gap
5. Gender Question Solved
6. Gender Difference In Reaction To Cancer
7. Gender Equality among Older Couples Plays a Vital Role in Their Sex Life
8. Gender Difference In Pain Experience Explained By Brain Diversity
9. Malaysia Likely To Outlaw Gender Selection Test
10. Transgender Experience - A Tool to Analyze Gender Difference By Stanford Scientist
11. Fertility Clinics Allowing Parents To Select Gender
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... , ... March 24, 2017 , ... “The Adventures of ... smart and silly dog who lives his life to the fullest, as God intended. ... published author Patti Holmgren, a mother and grandmother pursuing her passion for writing, especially ...
(Date:3/23/2017)... ... March 23, 2017 , ... Texas Physical Therapy Specialists (TexPTS) is pleased ... Building 2. The clinic is the group’s second in New Braunfels and 22nd in ... second New Braunfels location brings things full circle for the group, “It’s crazy to ...
(Date:3/23/2017)... OH (PRWEB) , ... March ... ... insurance and financial services firm serving the families and businesses of the ... community enrichment program. Northern Ohio Recovery Center (N.O.R.A.) is a nonprofit, community-based ...
(Date:3/23/2017)... ... March 23, 2017 , ... The ... and organized by HMP Communications Holdings, LLC, today announced that RestorixHealth® ... nationwide network of wound centers interested in becoming Certified Wound Specialist Physicians (CWSP®). ...
(Date:3/23/2017)... Laguna Hills, CA (PRWEB) , ... March 23, ... ... in document management and workflow solutions, today named The Resource Group as their ... annual customer and partner conference in Newport Beach, CA. The award recognizes ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... Research and Markets has announced the addition of the ... ... capillary electrophoresis market to grow at a CAGR of 7.06% during ... Market 2017-2021, has been prepared based on an in-depth market analysis ... and its growth prospects over the coming years. The report also ...
(Date:3/23/2017)... 23, 2017  Drug diversion is a significant ... deadly overdoses. A new oral fluid monitoring test, ... , reports more detailed and actionable information to ... improve therapy adherence, patient safety, and help to ... Oral fluid Rx Evaluation (CORE) system is the ...
(Date:3/23/2017)... SAN DIEGO , March 23, 2017 /PRNewswire/ ... for fast and accurate identification of individuals who ... at risk for a rare yet potentially deadly ... seizures and bipolar disorder.  The gene HLA-B*15:02 ... hypersensitivity reactions such as Stevens-Johnson syndrome and toxic ...
Breaking Medicine Technology: