ted with inflammation resulted in a greater activation of the PAG-RVM circuit, in males compared to females.

Additionally, morphine, an opioid drug or narcotic was found to reduce the response of this circuit to pain to in males. This effect however was not observed in the opposite sex. Morphine is being increasingly used in the treatment of post-operative pain. The results of the study provide important clues that morphine could be used differently in men and women to achieve maximum pain relief.

Pain is one of the most common reasons for patients to consult their physicians. Pain management, both acute and chronic has become one of the utmost priorities in the health care industry. Chronic pain associated with arthritis and fibromyalgia has been responsible for causing disability.

Women experience a greater chronic pain when compared to men and therefore require an increased dose of opioid drugs or narcotics, (morphine) for achieving the same amount of pain relief.

Clearly, more research is needed to better understand the sex-related difference in pain perception.


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