Navigation Links
Gastrin, Much More Than The Weight Management Hormone

It has been long contemplated that Gastrin is responsible for controlling the urge to eat and therefore can be effectively used for weight management programmes. Researchers today // have found it to be responsible for much more.

For the first time, researchers at the University of Texas Medical Branch at Galveston have linked the hormone gastrin to the body’s ability to maintain normal weight and normal insulin levels. In experiments conducted on mice, the UTMB researchers found that removing gastrin production triggered obesity, insulin resistance and metabolic changes that — in turn — increased the risk of colon cancer in the animals. The discoveries likely will have wide implications for clinical research on obesity, colon cancer and metabolism.

The team leader was Pomila Singh, Ph.D., professor of neurosciences and cell biology at UTMB. The co-authors were Stephanie Cowey Ph.D.; Michael Quast, Ph.D.; Dr. Ligia Maria Belalcazar; Dr. Jingwa Wei; Xiaoling Deng; and Randall Given, Ph.D.

“We have for the first time connected three things that weren’t known to be connected: gastrin, obesity and cancer,” Singh said. “We believe that the increase in obesity and the increase in insulin are increasing the risk of colon cancer in mice.”

In the current study, the researchers have uncovered previously unknown functions for gastrin. Until now, nobody had suspected that gastrin had anything to do with obesity or metabolic homeostasis — the physiological process that controls whether people have many or few fat cells, Singh said.

The experiments compared normal mice with mutant mice whose gastrin production capability was removed through genetic engineering. Researchers observed that if gastrin is removed in mice with normal diet, the mice become obese. So, the team set out to find out why removing gastrin made mice fat. Upon further evaluation, they learned that removing gastrin had disturbed the normal metabolic homeostasis .

“It appears that gastrin helps regulate those metabolic factors and metabolic hormones involved in keeping a person of normal weight,” Singh said. “If gastrin is missing in action, then you can actually become obese.”

Singh’s team will conduct further studies that will examine whether the gastrin hormone acts as a controlling, stabilizing mechanism on metabolic functions.

Source : University of Texas Mdical Branch
'"/>




Related medicine news :

1. Lose Weight With New Wonder Slimming FDA approved Prescription Drug
2. Weight-Loss Drinks Can Make You Gassy
3. Smoking Linked To Low Infant Birth Weight
4. Weight gain following smoking cessation not linked to Leptin
5. Helping Kids Attain a Healthy Weight
6. Weight-loss Products Dangerous
7. Weight and Blood Pressure
8. Low Birth Weight infants could have Problems in the Future
9. Excess Weight Can Affect Individuals as They Age
10. Low-Fat, High-Carb Diet Equally Effective In Weight Loss
11. Weight Gain Found To Increase The Risk Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology: