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Gabapentin Reduced Menopausal Symptoms as Estrogen – Study Find

Researchers at the University of Rochester when investigating for an alternative menopausal treatment have found that //gabapentin drug treated hot flashes as good as estrogen.

Gabapentin, a seizure drug lowered hot flashes by regulating the flow of calcium in and out of the cells, which helped in lowering body temperature.

flow risks like was researchers, who have been investigating new therapies for hot flashes for several years, report in the July Obstetrics and Gynecology journal that the seizure drug gabapentin is as effective as estrogen, which used to be the gold standard treatment for menopause symptoms.

Estrogen is no longer the preferred therapy because recent, large studies have shown that the hormone increases the risk of heart disease, stroke, breast cancer and Alzheimer's disease for some women. Given that news, millions of women have abandoned hormone replacement therapy (HRT) and are seeking other ways to ease symptoms. So-called natural remedies such as soy, herbal products or acupuncture have not proven safe or effective at this point.

The latest Rochester study is the first to compare gabapentin and estrogen head-to-head against a placebo. Although it showed a substantial placebo effect similar to other menopause studies – women taking the sugar pill reported a 54-percent reduction in hot flashes – the women taking gabapentin and estrogen reported even better results, with a 71 percent to 72 percent decline in symptoms.

‘Gabapentin does appear to be as effective as estrogen,’ said lead author Sireesha Y. Reddy, M.D., assistant professor of Obstetrics and Gynecology at the University of Rochester Medical Center. ‘Until now its efficacy relative to estrogen was unknown.’

Approximately 75 percent of postmenopausal women between the ages of 35 and 60 experience hot flashes. Gabapentin (sold under the trade name Neurontin) was approved by the FDA in 1994 to treat epileptic seizures but has bee
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