Navigation Links
Functional Taste Cells Cultured In Vitro

Nancy Rawson, PhD, a cellular biologist who is the principle investigator said that the new technique of in vitro culturing of taste cells would help them to discover molecules that can enhance or block different kinds of tastes.// Researchers from the Monell Chemical Senses Center have succeeded in growing mature taste receptor cells outside the body. They have also been successful in keeping the cells alive for a prolonged period of time. This is a break through as it opens a range of new opportunities for the scientists to understand the sense of taste and how it plays a vital role in nutrition, health and disease.

This technique may provide hope for people who have lost their sense of taste due to radiation therapy or tissue damage. This system gives us a way to test for drugs that can promote recovery. The results of this study are published in the journal Chemical Senses.

Taste receptor cells are located in taste buds on the tongue and in the throat. These cells contain the receptors that detect taste stimuli: sweet, sour, salty, bitter and savory. Each taste receptor cell lives for only about 10-14 days, after which it is replaced. The new taste cells develop from a population of undifferentiated precursor cells known as basal cells.

The Monell researchers obtained basal cells from rat taste buds and placed these cells in a tissue culture system containing nutrients and growth factors. In this environment, the basal cells divided and differentiated into functional taste cells. The new cells had the ability to stay alive for up to two months and were similar to mature taste cells in several key respects. These cells were subjected to functional assays which revealed that the cultured cells responded to either bitter or sweet taste stimuli with increases of intracellular calcium, another property characteristic of mature taste cells.

Hakan Ozdener, MD, PhD said that the taste cell culture system provides new insight into the differentiation process of the basal cells into the functional taste cells. This study also suggests that induction of these cells does not depend on the interactions with the nervous system. The use of cultured taste cells is that researchers could excise more control over the cell's surrounding environment and have better access to sub cellular mechanisms analyzed. Various studies such as how taste stimuli interact behaves to enhance good tastes or suppress unpleasant tastes. Similarly, new molecules, including potential artificial sweeteners or bitter blockers, can be evaluated to see if they interact with taste receptors to activate the cell.

Another important aspect is the use of this knowledge in the treatment for these patients who have lost their sense of taste from radiation or diseases. Researchers also hope to gain insight into how taste cell function changes across the lifespan, from infancy and childhood through old age.

Further research should be done using human taste cell biopsies and analyze it.


Related medicine news :

1. Functional foods reduce cholesterol
2. Shy Bladder Syndrome: A Social Phobia Or Functional Disorder Of Micturition?
3. Bio-Functional Garments That Could Revolutionize Fashion Industry
4. Functional Differences In Estrogen Receptor Could Be A Therapeutic Target
5. Patents: Appellate Board Becomes Functional
6. Hunger Found To Influence Taste
7. Understanding The Link Between Hunger and Taste
8. Understanding The Role Of Olfaction In Taste
9. More About The Coffee Bean Than Just A Heavenly Taste and Smell
10. Cocoa: Doesn’t Taste Like Red Wine But Has Benefits Like It
11. Punjabis Transfer Taste From Chicken To Prawns
Post Your Comments:

(Date:10/13/2017)... ... 13, 2017 , ... The American Board of Family Medicine's (ABFM) Board of ... Executive Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve ... Puffer’s retirement at the end of 2018. Upon assuming the role of President and ...
(Date:10/13/2017)... ... 2017 , ... PurhealthRX , a leading Health and Nutrition Company, is ... to full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing ... easily incorporated into liquid products, while reducing costs to end users. , The team ...
(Date:10/13/2017)... ... ... Lori R. Somekh, founder of the Law Office of Somekh & Associates ... special needs planning attorneys. “Membership in ElderCounsel helps our office remain up to date ... elder law attorneys nationwide,” said Somekh. , ElderCounsel was founded by ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers ... companies have a waiver for care if the client has a cognitive impairment diagnosis. ... pays for care, is often waived, so the benefits from their insurance start immediately,” ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading ... to advocate for action towards gender equality at their inaugural Summit in New York ... globe, and reached a social audience of over 3 million. To watch the Mobilize ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, Inc. ... earnings conference call and webcast on Friday, November 3, ... (EDT) and ending at approximately 8:30 a.m. (CDT) / ... the company,s 2017 financial performance and guidance for 2018, ... initiatives to enhance operational performance, and long-range financial outlook ...
(Date:9/25/2017)... , Sept. 25, 2017   Montrium ... Master File solutions, today—from the IQPC Trial Master ... , NL)—announced that EastHORN Clinical Services has ... clinical programs and TMF management. EastHORN, a leading ... eTMF platform to increase transparency to enable greater ...
Breaking Medicine Technology: