Navigation Links
From a Lowly Yeast, Researchers Divine a Clue to Human Disease

Working with a common form of brewer's yeast, University of Wisconsin-Madison researchers have uncovered novel functions of a key protein// that allow it to act as a master regulatory switch -- a control that determines gene activity and that, when malfunctioning in humans, may contribute to serious neurological disorders.

The work, published in the Dec. 8 issue of the journal Molecular Cell, shows how a mutation in a single gene can have widespread effects on regulation of the genetic program in a cell, causing some genes to be read more than normal and others less than normal.

While nearly every cell in an organism contains a complete set of DNA, each individual cell uses only a small fraction of that information at any given moment, explains David Brow, the senior author of the new study and a professor of biomolecular chemistry in the UW School of Medicine and Public Health. A host of proteins are responsible for controlling which genetic messages are read and how much of the information is used. Working with yeast, Brow and his colleagues show that a protein called Sen1 plays an important early role in this process.

Mutations in the human version of Sen1 are linked to neurological diseases, including a rare form of amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig's disease, and movement disorders. By exploring how Sen1 works in yeast, Brow provides a powerful tool other researchers can use to better understand the interplay of the protein and gene regulation in human disease.

"This work gives a method to start examining what the defect is in humans," he says.

In the past, says Brow, researchers looked at regulation of individual genes but not the whole genome at once. Using yeast, a small and relatively simple organism, the Wisconsin group developed a method to get a broad view of how Sen1 works and what happens when it doesn't work properly.

Normally, Sen1 acts like a molecula
'"/>




Page: 1 2

Related medicine news :

1. Vitamin Extends Life in Yeast, Dartmouth Medical School Researchers Find
2. Researchers urge caution in using ear tube surgery
3. Researchers Scale to assess the Severity of Epilepsy in Kids
4. Researchers trick Alzheimers Enzyme
5. Researchers find new HIV hiding place
6. New Hair in 15 Days Could Now Be A Possibility Say Researchers
7. Researchers developed world’s smallest toothbrus
8. Researchers discover receptor cells that can cause epilepsy
9. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
10. Researchers reversed the process of memory loss
11. Researchers Identify Key Gene That May Help Brain Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: From Lowly Yeast Researchers Divine Clue Human Disease

(Date:9/30/2014)... Las Vegas, NV (PRWEB) September 30, 2014 ... Marshall as a free introduction to SurvivalLife.com along with a ... has caught the attention of Shane Michaels, prompting an investigative ... the most well-known people in the survival and preparation niche, ... with all of the great classes and survival products that ...
(Date:9/30/2014)... Vegas, NV (PRWEB) September 30, 2014 ... is helping people perform better in and out of the ... and memory has caught the attention of Shane Michaels, prompting ... day-to-day grind, fatigue is the reason most people simply just ... whether that means staying focused at work, getting the motivation ...
(Date:9/30/2014)... 30, 2014 VisitandCare.com reports ... has gone up more than 79 percent in 2014, ... company also reported total revenue tripled for its entirety ... company’s professional strategy has allowed them to partner with ... for patient comfort and privacy — with state-of-the-art surgical ...
(Date:9/30/2014)... September 30, 2014 Hospice & ... annual “In Celebration” gala, honoring three outstanding individuals ... of striving to provide extraordinary and dignified comfort, ... a serious or life-limiting illness. , The event ... Rye, NY and recognized William (Bill) J. McGuinness, ...
(Date:9/30/2014)... Regenerative Medicine Solutions (RMS) is set to open ... RMS welcomes the launch of an entirely new facility, ... new treatment center for the Lung Institute. , ... Nashville, the hope is to bring awareness to those ... undiagnosed. With Nashville being a hub for medical technology, ...
Breaking Medicine News(10 mins):Health News:EverStryke: Review Exposes Joe Marshall’s Permanent Match Survival Product 2Health News:Elevate: Review Exposes Blue Star Nutraceutical’s Latest Supplement for Ultimate Brain Function, Focus, and Energy 2Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 2Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 3Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 4Health News:Hospice & Palliative Care of Westchester Honors Outstanding Individuals at Annual ‘In Celebration’ Gala 2Health News:Regenerative Medicine Solutions Expanding 2
... have covered one-third of the country's children in a ... than 11 million children in 1,301 counties of central ... hepatitis B, said Jiang Zuojun, the Vice-Minister for Health. ... their pace to reach the remaining two-thirds by the ...
... incidence of breast cancer at Brisbane's ABC headquarters at Toowong ... ,ABC managing director Mark Scott said that Dr Joanne Aitken ... by Dr Bruce Armstrong. ,Mr Scott added that ... alongside the panel. ,The review panel was established ...
... The British government's drug watchdog has warned yesterday that the doctors ... bipolar disorder in spite of it being one of the most ... are waiting on an average for eight years to be accurately ... almost 20 years of ill health, of which they might not ...
... poll that was conducted by the nursing union of the ... and harassment a continuing problem in// healthcare. ,Stating ... have suffered abuse from fellow staff and managers over the ... those bullied had wanted changes in their work so as ...
... Industry (ABPI) and the BioIndustry Association (BIA) recommended new ... with extreme care and caution while testing pioneering drugs. ... March left six volunteers in the state of coma. ... The new drug was tested at the Parexel trial ...
... studies shows that alternative and complementary therapies may have ... menopause.// The review article is published in the July ... the JAMA/Archives journals. ,Twenty-five million women will ... of them will experience hot flashes, night sweats, vaginal ...
Cached Medicine News:Health News:Breast Cancer Review Panel Adds Two Experts 2Health News:Bipolar Disorder Not Being Accurately Diagnosed By Doctors In UK 2Health News:Alternative Therapies May Not Ease Menopause Symptoms 2
(Date:9/30/2014)... LOS ANGELES , Sept. 30, 2014   ... apnea shopping destination , today announced that it now ... ResMed . AirSense CPAPs are the first sleep apnea ... makes it simple and easy to track and share ... the overall effectiveness of their CPAP therapy.  In addition, ...
(Date:9/30/2014)... BRUNSWICK, N.J., Sept. 30, 2014 The ... Kessler Foundation and New Jersey Health Foundation (NJHF) ... and patient care programs has been announced by ... officer of Kessler Foundation and James M. ... "The experience of New Jersey Health ...
(Date:9/30/2014)... -- The Eastern European medical device industry is in ... as new medical-device manufacturers are constantly trying to penetrate ... to reduce the cost incurred for placing their products ... effective means to achieve this target. This research service ... and provides profiles of key distributors in ...
Breaking Medicine Technology:Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 2Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 3Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 4Kessler Foundation Partners with New Jersey Health Foundation To Start Innovative Companies To Change the Lives of People with Disabilities 2Medical Technologies Distributor Profiles in Eastern Europe 2Medical Technologies Distributor Profiles in Eastern Europe 3
... DIEGO, Aug. 28 Vical Incorporated,(Nasdaq: VICL ... subject in its,Phase 1 trial of the company,s ... placebo-controlled trial will,evaluate safety, tolerability and immune responses ... 45 at two U.S. clinical sites. "We ...
... such ... infectious-disease outbreaks, SEATTLE, Aug. 28 In ... Fred,Hutchinson Cancer Research Center confirm that the avian influenza A ... within a family in,Indonesia. The findings, by biostatistician Ira M. ...
Cached Medicine Technology:Vical Begins Phase 1 Trial of DNA Vaccine Against H5N1 Pandemic Influenza 2Vical Begins Phase 1 Trial of DNA Vaccine Against H5N1 Pandemic Influenza 3Vical Begins Phase 1 Trial of DNA Vaccine Against H5N1 Pandemic Influenza 4Study Confirms Limited Human-To-Human Spread of Avian-Flu Virus in Indonesia in 2006 2Study Confirms Limited Human-To-Human Spread of Avian-Flu Virus in Indonesia in 2006 3Study Confirms Limited Human-To-Human Spread of Avian-Flu Virus in Indonesia in 2006 4
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: