Navigation Links
Fresh approach to TB treatment

A NOVEL approach to the treatment of tuberculosis (TB) has been investigated by a team of molecular geneticists in the United Kingdom, following the direction of a new gene in mycobacteria, one type of which causes the disease.//The presence of the gene opens up opportunities for the use of azole drugs which are already available for ht etreatment of fungal infections.

These treatments such as in Canestan and Diflucan are central to antifungal treatments of patinets suffering infections such as Canadida albicans but also increasingly in internal fungal infections.New azole drugs are being developed against fungi as the incidence of infection has increased dramatically in recent years.The potential value of these drugs against mycobacteria had not received attention because were not thought to contain this drug target which is associated with the sterol bio-synthesis pathway.

Laboratory tests have already shown that some of these drugs work on various mycobacteria, including the BCG strain that is used for inoculations and Mycobacterium Smegmatis, generally an opportunistic pathogen.The equivalent of the target of the drugs in fungi has been detected in several mycobacterial pathogens including that causing TB and the protein in the BCG strain is identical to that in M. Tuberculosis causing TB.

These results suggest that the drugs are also likely ot be active against the strains that cause infection.Further tests will confirm which of the family of azole drugs could be candidates for fast-tracking the drug discovery programme.Professor Steven Kelley, of the Institute of Biological Sciences at University of Wales Aberystwyth, said:“The sterol biosynthesis pathways are commonly found in fungi, animals and plants but this was the first that this gene had been found in bacteria. We now see the gene in several of the databases containing the genetic blueprints of different mycobacteria.

“It gives us the prospect of using exis ting anti-fungal compounds where there is knowledge about toxicological safety or at least provides strong leads for drug development - means that these drugs could be suitable to combat TB many years before an entirely new type of drug can be discovered. Thes ecompounds should be considered urgently,” added Professor Kelly.


'"/>




Related medicine news :

1. Fresh warnings to doctors regarding abortion pill
2. Fresh Cases of Bird-Flu Prepares the Ground for More Chicken Martyrs
3. Fresh Bird Flu Cases Spotted In Southern Russia
4. Pakistan Scared By Fresh Bird Flu Case
5. Fresh Polio Cases Reported In Uttar Pradesh
6. Nothing Can Equate Fresh Vegetables and Fruits
7. Fresh Outbreak Of Bird Flu In Nigeria
8. Foreign Fresher Students Offered Scholarship By Fudan
9. Fresh bird flu vaccines made in China
10. Freshness Dating? Researchers Express Doubts
11. WHO Issues Fresh Guidelines To Long Distance Air Travelers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/21/2017)... ... September 21, 2017 , ... ... communities, nine governmental public health departments have been awarded five-year accreditation status through ... that the benefits of being served by a PHAB-accredited health department now ...
(Date:9/21/2017)... (PRWEB) , ... September 21, 2017 , ... ... using Microscan’s LVS 7510 at the Global GS1 Healthcare Conference 2017 in Chicago, ... the life-sciences industry for ensuring label quality and improving patient safety. , ...
(Date:9/21/2017)... ... 2017 , ... Japanese Zen artist couple, Fumie and Kentaro Mune, have announced ... October at Miranda Kuo Gallery on Lower East Side, NYC. This exhibition will feature ... Wanderlust , one of the largest US yoga online media outlets in the ...
(Date:9/21/2017)... ... September 21, 2017 , ... Sagora Senior Living, one ... at Kingwood Assisted Living and Memory Care located at 24025 Kingwood Place Drive, ... assisted living apartments, 43 memory care apartments and 23 extended care apartments. Modern ...
(Date:9/20/2017)... (PRWEB) , ... September 20, 2017 , ... ... center in Prescott, Arizona, is now accredited by The Joint Commission for chemical ... organization that accredits and certifies U.S. health care organizations that meet the commission’s ...
Breaking Medicine News(10 mins):
(Date:9/9/2017)... , Sept. 8, 2017 ... Mobile MRI Unit coming to Washington DC ... When: Tuesday, September 12 th – Monday, September 18 ... D.C. offering free MRI brain scans to the public.Where:  ... be parked at 501 K Street NW, Washington, D.C.What:BTF brings its nationwide ...
(Date:9/9/2017)... INDIANAPOLIS , Sept. 9, 2017  Eli Lilly ... key primary and secondary endpoint data for lasmiditan, an ... migraine, which demonstrated statistically significant improvements compared to placebo ... be highlighted today at the 18th Congress of the ... . "The data presented today demonstrate lasmiditan,s ...
(Date:9/7/2017)... , Sept. 7, 2017  For nearly two decades, New Life ... the Assisted Reproduction Insurance industry. Today, New Life Agency announces a powerful ... ... (PRNewsfoto/PharmaCareCard) ... http://pharmacarecard.com/ ...
Breaking Medicine Technology: