Navigation Links
Fresh approach to TB treatment

A NOVEL approach to the treatment of tuberculosis (TB) has been investigated by a team of molecular geneticists in the United Kingdom, following the direction of a new gene in mycobacteria, one type of which causes the disease.//The presence of the gene opens up opportunities for the use of azole drugs which are already available for ht etreatment of fungal infections.

These treatments such as in Canestan and Diflucan are central to antifungal treatments of patinets suffering infections such as Canadida albicans but also increasingly in internal fungal infections.New azole drugs are being developed against fungi as the incidence of infection has increased dramatically in recent years.The potential value of these drugs against mycobacteria had not received attention because were not thought to contain this drug target which is associated with the sterol bio-synthesis pathway.

Laboratory tests have already shown that some of these drugs work on various mycobacteria, including the BCG strain that is used for inoculations and Mycobacterium Smegmatis, generally an opportunistic pathogen.The equivalent of the target of the drugs in fungi has been detected in several mycobacterial pathogens including that causing TB and the protein in the BCG strain is identical to that in M. Tuberculosis causing TB.

These results suggest that the drugs are also likely ot be active against the strains that cause infection.Further tests will confirm which of the family of azole drugs could be candidates for fast-tracking the drug discovery programme.Professor Steven Kelley, of the Institute of Biological Sciences at University of Wales Aberystwyth, said:“The sterol biosynthesis pathways are commonly found in fungi, animals and plants but this was the first that this gene had been found in bacteria. We now see the gene in several of the databases containing the genetic blueprints of different mycobacteria.

“It gives us the prospect of using exis ting anti-fungal compounds where there is knowledge about toxicological safety or at least provides strong leads for drug development - means that these drugs could be suitable to combat TB many years before an entirely new type of drug can be discovered. Thes ecompounds should be considered urgently,” added Professor Kelly.


Related medicine news :

1. Fresh warnings to doctors regarding abortion pill
2. Fresh Cases of Bird-Flu Prepares the Ground for More Chicken Martyrs
3. Fresh Bird Flu Cases Spotted In Southern Russia
4. Pakistan Scared By Fresh Bird Flu Case
5. Fresh Polio Cases Reported In Uttar Pradesh
6. Nothing Can Equate Fresh Vegetables and Fruits
7. Fresh Outbreak Of Bird Flu In Nigeria
8. Foreign Fresher Students Offered Scholarship By Fudan
9. Fresh bird flu vaccines made in China
10. Freshness Dating? Researchers Express Doubts
11. WHO Issues Fresh Guidelines To Long Distance Air Travelers
Post Your Comments:

(Date:6/25/2016)... ... , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize ... Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into ... Simply select a ProHand generator and drag it above media or text in the ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in Bogota. Colombia ... ... Sandra ... ... Astellas is a pharmaceutical company ...
(Date:6/23/2016)... MEDIA, Pa. , June 23, 2016 ... treatments in an outpatient dialysis facility.  Treatments are usually ... to 6 hours per visit, including travel time, equipment ... on a patient, but especially grueling for patients who ... residents of a skilled nursing and rehabilitation centers for ...
(Date:6/23/2016)... 2016 The Biotechnology industry might ... present great opportunities to investors. assesses the recent ... (NYSE: XON ), Vertex Pharmaceuticals Inc. (NASDAQ: ... ARNA ), and Regeneron Pharmaceuticals Inc. (NASDAQ: ... receive your complimentary trade alerts at: ...
Breaking Medicine Technology: