Navigation Links
Fresh approach to TB treatment

A NOVEL approach to the treatment of tuberculosis (TB) has been investigated by a team of molecular geneticists in the United Kingdom, following the direction of a new gene in mycobacteria, one type of which causes the disease.//The presence of the gene opens up opportunities for the use of azole drugs which are already available for ht etreatment of fungal infections.

These treatments such as in Canestan and Diflucan are central to antifungal treatments of patinets suffering infections such as Canadida albicans but also increasingly in internal fungal infections.New azole drugs are being developed against fungi as the incidence of infection has increased dramatically in recent years.The potential value of these drugs against mycobacteria had not received attention because were not thought to contain this drug target which is associated with the sterol bio-synthesis pathway.

Laboratory tests have already shown that some of these drugs work on various mycobacteria, including the BCG strain that is used for inoculations and Mycobacterium Smegmatis, generally an opportunistic pathogen.The equivalent of the target of the drugs in fungi has been detected in several mycobacterial pathogens including that causing TB and the protein in the BCG strain is identical to that in M. Tuberculosis causing TB.

These results suggest that the drugs are also likely ot be active against the strains that cause infection.Further tests will confirm which of the family of azole drugs could be candidates for fast-tracking the drug discovery programme.Professor Steven Kelley, of the Institute of Biological Sciences at University of Wales Aberystwyth, said:“The sterol biosynthesis pathways are commonly found in fungi, animals and plants but this was the first that this gene had been found in bacteria. We now see the gene in several of the databases containing the genetic blueprints of different mycobacteria.

“It gives us the prospect of using exis ting anti-fungal compounds where there is knowledge about toxicological safety or at least provides strong leads for drug development - means that these drugs could be suitable to combat TB many years before an entirely new type of drug can be discovered. Thes ecompounds should be considered urgently,” added Professor Kelly.


'"/>




Related medicine news :

1. Fresh warnings to doctors regarding abortion pill
2. Fresh Cases of Bird-Flu Prepares the Ground for More Chicken Martyrs
3. Fresh Bird Flu Cases Spotted In Southern Russia
4. Pakistan Scared By Fresh Bird Flu Case
5. Fresh Polio Cases Reported In Uttar Pradesh
6. Nothing Can Equate Fresh Vegetables and Fruits
7. Fresh Outbreak Of Bird Flu In Nigeria
8. Foreign Fresher Students Offered Scholarship By Fudan
9. Fresh bird flu vaccines made in China
10. Freshness Dating? Researchers Express Doubts
11. WHO Issues Fresh Guidelines To Long Distance Air Travelers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... , ... July 19, 2017 , ... ... with a larger audience and increased funds raised to support fine arts programs ... of “Disney Aladdin Kids” in Freed-Hardeman University’s Loyd Auditorium. , More than ...
(Date:7/20/2017)... ... July 19, 2017 , ... ... Health Resources and Services Administration (HRSA) grant to train predoctoral dental students in ... needs in rural and underserved areas. , The Predoctoral Pediatric Training Project (PPTP), ...
(Date:7/20/2017)... ... , ... “Fidget”: a fun-filled, action-packed memoir of adventures. “Fidget” is the creation ... teacher who was a summa cum laude graduate of Gardner Webb University. She has ... After her retirement from public school, Lynn continued to pursue her love for music ...
(Date:7/18/2017)... Falls Church, VA (PRWEB) , ... July 18, ... ... CFR Part 11) , What Strategic Decisions Do You Need to Consider?, ... http://www.fdanews.com/newfinalrule      , 42 CFR Part 11, “Final Rule for Clinical ...
(Date:7/18/2017)... ... July 18, 2017 , ... An inventor from Seattle, ... and easy way to clean, scrub and moisturize the back and other hard-to-reach areas ... surgery that limited movement in my upper body, particularly my shoulders. I found it ...
Breaking Medicine News(10 mins):
(Date:7/11/2017)... Research Corp., also known as ,The Epigenetics Company, announced today the release ... manner using the myDNAge ™ test. Based on Horvath,s Clock, so ... and biostatistics at the David Geffen School of Medicine at UCLA ... DNAge ™ technology is used to analyze DNA methylation patterns of ... ...
(Date:7/11/2017)... -- Dr. Echenberg, founder of Echenberg Institute, is announcing a new safe and ... painful intercourse and other painful pelvic pain conditions such as pelvic floor ... ... ... -based start-up company, VuVatech LLC, fills a void in the women,s ...
(Date:7/10/2017)... 2017  BDI Group subsidiary Pathway Purchasing Network, ... organization serving specialty pharmacies, home infusion companies and ... significant, value-added member programs designed to help organizations ... and improve access and affordability for patients who ... Pathway has worked ...
Breaking Medicine Technology: