Navigation Links
Formula Predicts Osteoporotic Fracture Risk

A new study in the October issue of Radiology says that a mathematical formula can predict the risk of osteoporotic fractures in women with 75 percent accuracy.// Researchers say this will allow doctors to formulate a treatment plan accordingly.

"Approximately 45 percent of women have different levels of bone mineral density between their hip and their spine, leading to uncertainty as to how physicians should assess their future fracture risk," said the study's lead author, Margaret Joy Henry, B.Sc(Hons)., Ph.D., statistician in the Department of Clinical and Biomedical Sciences at The University of Melbourne, Australia. "We have derived an equation that successfully predicted 75 percent of fractures in women, two years after their initial measurements were taken."

Women with osteoporosis have brittle bones that are more likely to break as a result of a minor bump or fall. Bones affected by osteoporosis are less dense than normal bones, due to larger pores in the bone, reduced calcium levels and fewer blood vessels.

The equation developed by Dr. Henry and colleagues takes into account a variety of risk factors, not just bone mineral density. A patient's likelihood of falling, low bone mass, excess or low body weight and additional factors are combined into a single formula that can indicate to a physician how serious a woman's fracture risk may be. Treatment strategies may then be targeted on the basis of a woman's predicted outcome.

A total of 231 elderly women who had sustained a low-trauma fracture of the hip, spine, humerus or forearm during a two-year period were recruited, as well as 448 elderly women who were selected randomly and had not sustained a fracture during the same two-year period.

The equation was developed based on measurements obtained in this study population. It was then tested in a third group of women from the community, who were randomly selected to be followed for a six-year period to determine the success of the formula for predicting fractures.

By using the formula, 75 percent of fractures were successfully predicted two years after the baseline measurements were obtained. The authors also discovered that heavier body weight seemed to increase the force applied to the skeleton during a fall. Findings of most previous studies indicated that lighter body weight led to increased risk of fracture, due to lower bone mass.

Development of this formula to predict future fracture risk is important because it will allow physicians to better adapt treatment strategies for women with osteoporosis, especially by taking into consideration different bone density measurements throughout the body. A variety of treatment regimens can be used, including hormone replacement therapy, non-hormonal medicines, vitamin D and calcium supplements, and additional therapies such as calcitriol--an active form of vitamin D that improves the absorption of calcium from the digestive process.

"As the average age of the population increases, the number of fractures attributable to osteoporosis is set to increase dramatically," said Dr. Henry. "The ability to predict fracture risk, based on simple clinical measurements, will assist in targeting treatment for people at highest risk, thus helping reduce the burden of this disease."

Dr. Henry and colleagues are currently assessing risk factors in a large cohort of men to develop a similar formula for use in the male population.

Source-Eurekalert
RAS
'"/>




Related medicine news :

1. Ajanta Launches Worlds First Once-A-Day Nimesulide Oral Formulation
2. The Happiness Formula....
3. Indian Government Keen On JE Vaccine Supply And Patenting Of Indian Medicine Formulations
4. UN Formulates Action Plan for Relief to Recovery in Quake-hit Areas of Pakistan
5. Infant’s Formula for good health- Breast-feed, beneficial than formula-fee
6. Formula milk suffering due to commercial interests
7. Efficacy Of Sports-Formulated Jelly Beans In Warding Off Fatigue To Be Studied
8. Winning Formula For Mother and baby - Breast Feeding!
9. Infant Formula With High Iron Content Packs Brain Disorder
10. West African Ministers Formulate Plan To Combat Bird Flu
11. Prebiotics Supplemented Formula Milk Reduces Dermatitis Risk
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... ... March 28, 2017 , ... ... medical society dedicated to advancing the science and clinical practice of radiosurgery, ... RSSearch Patient Registry, a multi-institutional, observational registry established to standardize data collection ...
(Date:3/28/2017)... ... March 28, 2017 , ... Alert Sentry Group LLC., a ... Personal Emergency Response Systems), the iSAFE and the iSAFE Plus. These iSAFE products are ... of their kind, the iSAFE and iSAFE Plus offer direct GPS Location and two-way ...
(Date:3/28/2017)... ... March 28, 2017 , ... WHO: , Dr. Paul Thomas; Dr. ... , Medical doctors and PhD scientists will speak to the press on behalf of ... support of an independent vaccine safety commission. , WHERE: , Zenger Room, National ...
(Date:3/28/2017)... ... 28, 2017 , ... The Radiology Business Management Association (RBMA) is ... its new executive director. Mr. Still was selected through a careful months-long search by ... he is known to our members, has been a part of building the RBMA ...
(Date:3/28/2017)... ... March 28, 2017 , ... Award-winning medical group ... serving as new board chair for Orange County health care system CalOptima Friday. ... of soon-to-be former chair Mark Refowitz’s term, which runs through June 30 of ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... STRASBOURG, France and TEL AVIV, Israel ... opening a subsidiary in Israel . This new ... , will be mostly dedicated to research and development of novel ... Emosis Ltd will also, when relevant, locally support commercialization and sales ... ...
(Date:3/28/2017)...  CASI Pharmaceuticals, Inc. (Nasdaq: CASI), a biopharmaceutical ... other unmet medical needs, announced today two poster ... annual meeting.  The first poster to be presented ... ENMD-2076 in Combination with Anti-PD1 in Syngeneic Cancer ... presented on April 4 is entitled " Kinase ...
(Date:3/28/2017)... The global flow cytometry ... by 2025, according to a new study by Grand ... and cancer is expected to upsurge the demand for ... coming years. In addition, higher number of physicians is ... cell therapy, due to adverse effects caused by chemotherapy ...
Breaking Medicine Technology: