Navigation Links
Fittest Of Newborn Neurons Survive

Researchers at the Salk Institute for Biological Studies say that even in young neurons it is the survival of the fittest. Whether a new neuron lives or is killed off// depends on its ability to establish connections with other cells. This new study is conducted by the lab of Fred H. Gage, Ph.D., a professor in the Gene Expression Laboratory and the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Diseases. It says that a subunit of the NMDA receptor is vital in the integration of new neurons in the brain. The study is due to appear in a forthcoming issue of Nature.

The NMDA receptor is activated by the neurotransmitter glutamate, a chemical released by neurons in order to transmit information to neighboring cells. Whenever the receptor picks up a glutamate signal it is stimulated and relays the signal. But for newborn neurons that signal means something else entirely -- survival.

"When we removed the NMDA receptor, that is when cells make connections in response to glutamate in the environment, the newborn neurons withered and died at a specific stage of their maturation," explains Gage. " The NMDA receptor modulates synapse formation and determines what pattern of input activity new neurons receive, which in turn determines survival or death."

Combining mouse genetics and gene transfer techniques, Gage and a team headed by former postdoctoral fellow Ayumu Tashiro, Ph.D., injected a virus carrying a pair of molecular shears capable of deleting a gene encoding part of the NMDA receptor into the hippocampus, a brain region harboring neural stem cells that give rise to new neurons. Newly born neurons infected with virus were marked by a fluorescent dye enabling detection of neurons derived from those cells.

A few weeks later, animals that received the virus showed fewer fluorescent neurons compared to mice injected with a benign virus lacking the shears, meaning fewer new neurons had survived origina
'"/>




Page: 1 2 3

Related medicine news :

1. Baltimore is Americas Fittest City; Chicago the Fattest
2. Screening Newborns Questioned
3. Cooling Can Reduce The Risk Of Brain Damage In Oxygen Deprived Newborns
4. Newborns Know how to make eye contact
5. Early Screening For Hearing Impairments In Newborn Can Be Helpful
6. New Portable Helmet Scanner To Examine Newborns
7. Newborns Affected By Antidepressant Intake Of Mothers
8. NHS To Screen Newborn Babies For Hearing Impairment
9. Use Of Alcohol During Pregnancy Affects Newborns
10. Exposure To Solvents May Harm Pregnant Women And Newborns
11. Bribery has Claimed the Life of a Newborn in Madhya Pradesh
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Fittest Newborn Neurons Survive

(Date:7/25/2014)... when genes are switched on or off plays a ... regulate metabolism, UT Southwestern Medical Center researchers have found., ... treat obesity and diabetes, since the transcription factor involved ... to influence the body,s sensitivity to insulin and leptin ... body,s regulation of food intake and sugar disposal, and ...
(Date:7/25/2014)... (PRWEB) July 25, 2014 Innerspire, LLC ... joined the company as a Creative Enrollment Specialist. In ... relationship building skills as well as his accomplished design ... small business clients, and to service the creative ... Additionally, Greg will work with small business owners and ...
(Date:7/25/2014)... The American Brain Tumor Association (ABTA) ... CommYOUnity™” during its annual patient and family conference in ... brain tumor community as we – the first and ... services and funding brain tumor research – extend our ... tumor awareness and getting our materials and services into ...
(Date:7/25/2014)... July 25, 2014 There are 700,000 people ... diagnosed each day. Though when someone hears the words, “you ... are unsure of the next step and where to turn. ... figure out that next step by providing and pursuing the ... than Brian Olson, member of the ABTA’s Board of Directors ...
(Date:7/25/2014)... Progress in understanding the molecular genetics of brain ... brain tumor treatments, according to Patrick Wen, MD, professor ... for Neuro-Oncology, Dana-Farber Cancer Institute. , At the American ... in Chicago, July 25-26, Dr. Wen will moderate a ... the development of new treatments and advancing strategies to ...
Breaking Medicine News(10 mins):Health News:Manipulating key protein in the brain holds potential against obesity and diabetes 2Health News:Innerspire, LLC Continues National Expansion 2Health News:Innerspire, LLC Continues National Expansion 3Health News:Innerspire, LLC Continues National Expansion 4Health News:American Brain Tumor Association Unveils Brand Identity for Newly Launched Volunteer Network 2Health News:American Brain Tumor Association Unveils Brand Identity for Newly Launched Volunteer Network 3Health News:American Brain Tumor Association Board of Directors Member Shares Story of Brain Tumor Survivorship 2Health News:American Brain Tumor Association Board of Directors Member Shares Story of Brain Tumor Survivorship 3Health News:Immunotherapy, Targeted Molecular Therapies Among Promising New Treatments for Brain Tumors 2Health News:Immunotherapy, Targeted Molecular Therapies Among Promising New Treatments for Brain Tumors 3Health News:Immunotherapy, Targeted Molecular Therapies Among Promising New Treatments for Brain Tumors 4
... , , Psychiatric Care ... , , OAKLAND, Calif., July 27 ... a complaint against Mohamed El-Sabaawi with the California Medical Board ... a number of state mental health hospitals without a valid ...
... intensive therapy, study shows , MONDAY, July 27 (HealthDay ... taking medications that lower blood pressure and cholesterol, people ... of developing the most serious complications associated with the ... in the July 27 issue of the Archives ...
... , , , NEW ... medical technology company developing a minimally invasive drug delivery platform for the regional ... progress. In addition, the Company reported its financial results for the second ... , , , Screened 40 ...
... , ARLINGTON, Va., July 27 ... to the article in Pediatrics: H. von Rettberg, T. Hannman, U. ... Di(2-Ethylhexyl)Phthalate-Containing Infusion Systems Increases the Risk for Cholestasis, Pediatrics 124(2): 710-716 (August ... - delivery of nutrition intravenously via plastic tubing - is a life-saving ...
... , , , ... cover issues related to the diagnosis and treatment of infertility with ... including the emotional, scientific and financial aspects. Discussions include information about ... use of donor sperm or donor eggs. , , ...
... , , LOS ... Center specializes in cardiothoracic surgery including mitral valve replacement. Fatigue ... In fact, most people brush off these seemingly minor symptoms and ... of the need for mitral valve replacement ...
Cached Medicine News:Health News:Union of American Physicians and Dentists: Court Appointee El-Sabaawi Practicing Medicine Without a License? 2Health News:Tight Management of Type 1 Diabetes Worth the Effort 2Health News:Tight Management of Type 1 Diabetes Worth the Effort 3Health News:Delcath Systems Provides Update on Progress 2Health News:Delcath Systems Provides Update on Progress 3Health News:Delcath Systems Provides Update on Progress 4Health News:Delcath Systems Provides Update on Progress 5Health News:Delcath Systems Provides Update on Progress 6Health News:Delcath Systems Provides Update on Progress 7Health News:ACC Responds to Study Published in Pediatrics About Phthalate and IV Tubing 2Health News:Southern California Surgical Center (heart411.com) Specializes in Mitral Valve Replacement 2
(Date:7/24/2014)... VIEW, Calif. , July 24, 2014  IRIDEX ... it will release its second quarter 2014 financial results ... 2014. In conjunction with the release, the Company ... at 5:00 p.m. Eastern Time on ... of the quarter and other business developments. ...
(Date:7/24/2014)... 2014 Omnicell, Inc. (NASDAQ: ... supply management solutions and analytics software for healthcare ... to discuss the Company,s Second Quarter 2014 financial ... earnings conference call and webcastWhen: , July ... chairman, president and chief executive officer ...
(Date:7/24/2014)... N.J., July 24, 2014  IGI Laboratories, Inc. (NYSE MKT: ... manufacturing company, announced its financial results for the second quarter ... , Total revenues of $6.5 million in the ... same quarter in 2013 , Total revenues of $13.3 ... increase of 78% over the same period in 2013 ...
Breaking Medicine Technology:Omnicell to Release Second Quarter 2014 Earnings Results on July 31 2IGI Laboratories Announces Second Quarter 2014 Results 2IGI Laboratories Announces Second Quarter 2014 Results 3IGI Laboratories Announces Second Quarter 2014 Results 4IGI Laboratories Announces Second Quarter 2014 Results 5IGI Laboratories Announces Second Quarter 2014 Results 6IGI Laboratories Announces Second Quarter 2014 Results 7
... New results from the largest multicenter clinical trial for ... the International Society for Heart & Lung Transplantation (ISHLT) ...  Results show clinical benefit for the use of Everolimus ... 721 randomized patients at 67 medical centers spanning 5 ...
... April 14, 2011 Oxford Finance Corporation (Oxford), a ... a $2 million equipment loan with Synta Pharmaceuticals Corp. ... compounds for use in Synta,s ongoing clinical trials in ... "Synta Pharmaceuticals has a diverse drug pipeline, including ...
Cached Medicine Technology:Results From Largest Study of Anti-Rejection Therapy for Heart Transplant Patients Will be Released at ISHLT Meeting 2Results From Largest Study of Anti-Rejection Therapy for Heart Transplant Patients Will be Released at ISHLT Meeting 3Results From Largest Study of Anti-Rejection Therapy for Heart Transplant Patients Will be Released at ISHLT Meeting 4Oxford Finance Corporation Provides a $2 Million Equipment Facility to Synta Pharmaceuticals Corp. 2