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Fishing for a Speedy Recovery After Chemotherapy or Marrow Transplant

ossible to visualize the blood stem cells in live fish.

The researchers also confirmed their observations in mammalian models. When dmPGE2 was added to mouse embryonic stem cells in the lab, production of blood stem cells increased. In mice that underwent bone marrow transplant, treatment with dmPGE2 led to enhanced blood-stem-cell formation, and the stem cells remained present in the marrow more than six months after transplantation, indicating long-term engraftment. The fact that we confirmed the zebrafish discovery in a mammalian system suggests it may also be applicable in humans, says Goessling.

The clinical trial, projected to begin in 2008 at Childrens Hospital Boston in conjunction with the Dana-Farber/Harvard Cancer Center, will recruit patients undergoing cord blood transplant for leukemia.

Patients will receive cord blood to replenish their blood systems, some of it treated with dmPGE2 to enhance blood-stem-cell formation. Having more stem cells should help the blood system to regrow faster and minimize complications, such as infections, says North.


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