Navigation Links
First Treatment to Directly Target Tumor Blood Supply

For the first time, physician-scientists at NewYork-Presbyterian Hospital/Weill Cornell Medical Center in New York City have demonstrated// in patients the ability of an antibody to directly target the blood supply of a wide variety of tumors, leaving healthy tissues unharmed.

The Phase I clinical trial tested an antibody called J591, targeted to the prostate specific membrane antigen (PSMA).

PSMA has been an attractive target for cancer drug development because it is not only present in high amounts in prostate cancers but it also is the only known molecular target present on tumor blood vessels but not normal blood vessels. The ability to target PSMA on blood vessels would provide a way to directly attack a tumor’s blood supply without affecting normal blood vessels.

"Anti-angiogenic" cancer therapies that focus on the tumor's blood supply are not new. However, other such treatments starve tumors of their blood supply indirectly, by reducing blood vessel growth signals. J591 may work in a new way, taking anti-angiogenic therapy to the next level by directly targeting PSMA on the cells of the tumor blood vessels and then zooming in for the kill.

The trial, which appears in the Feb. 10 issue of the Journal of Clinical Oncology, involved 27 cancer patients with a wide range of solid tumors -- including kidney, bladder, lung, breast, colorectal, pancreas and melanoma. All patients had widespread disease that had failed conventional treatments.

"Prior to this trial, we had laboratory data that indicated PSMA was present on tumor but not normal blood vessels," explains the study's senior author, Dr. Neil H. Bander, a urological cancer specialist at NewYork-Presbyterian/Weill Cornell and the Bernard and Josephine Chaus Professor of Urological Oncology at Weill Cornell Medical College. "We hypothesized that we could use an antibody to PSMA to specifically target tumor blood supply. This was a proof-of-principle t rial to confirm -- or reject -- our hypothesis."

The research team used a radioactive tracer, attached to the antibody, to follow J591's progress throughout the body.

"We showed that J591 can directly target the tumor's blood vessels," Dr. Bander says. "That's an important first. It represents the difference between laying siege to a village vs. sending in troops with heavy artillery. Current anti-angiogenic approaches starve the blood vessels of growth signals, but with J591, one directly targets a lethal blow right at the tumor blood supply."

As its name implies, PSMA was first spotted in prostate cancers. However, in 1998, Dr. Bander's team found the antigen to be present in the blood vessels of a wide range of tumor types -- but not healthy vasculature. This finding has been subsequently verified by several research teams.

As expected, the antibody therapy left healthy tissue alone, resulting in very low levels of toxicity for patients. The relatively short, small trial did not turn up significant reductions in tumor volume, but Dr. Bander says the trial wasn't designed to do so.

"This was a proof-of-principle study designed purely to confirm that we could successfully target tumor vasculature without targeting normal tissue," he says. "Now that we have confirmed specific and accurate targeting, in subsequent studies we will arm the J591 antibody with drugs or radioactivity, and then we will assess tumor response. We are already using such armed antibodies in patients with prostate cancer and have been able to show significant anti-tumor activity."

The big news now is that J591, and compounds like it, could someday offer cancer patients a brand new weapon as they fight the disease. But Dr. Bander’s team doesn't expect that cancer patients would rely on PSMA-targeted therapies alone.

"In the future, we envision a multi-pronged attack on the tumor -- for example, combining thera pies aimed directly at the malignant cells, along with therapies to both directly kill the tumor's blood supply as well as prevent it from re-growing," he says.

When it comes to fighting cancer, any new treatment option is always welcome, he adds. "With an antibody to PSMA like J591, we hope to open up a whole new front in the war against this disease."


Related medicine news :

1. First Vaccine Designed for Africa Cleared for Testing in Humans
2. Ajanta Launches Worlds First Once-A-Day Nimesulide Oral Formulation
3. First human clone is near
4. First Artificial Heart patient has Major setback
5. First head-to-head trials of once weekly Fosamax and Actonel therapies
6. WHO Declares Vietnam First Country to Control SARS
7. Russia Reports First SARS Case
8. Hope for First New Melanoma Treatment in Decades
9. First global SARS meet opens
10. Stanford Medical Center Implements The First Virtual Cardiac Ultrasound
11. Hyderabad To Have Asia’s First Catheter Making Uni
Post Your Comments:

(Date:12/1/2015)... ... 2015 , ... CloudLIMS today announced that it is the ... the New Products and Services category for its innovative product offering, BioTracer. ... that helps labs organize data and track samples with storage inventories. BioTracer's SaaS ...
(Date:12/1/2015)... ... December 01, 2015 , ... Diabetic foot ... States. Podiatrists are well aware that psychology-based patient non-compliance (disobedience of a health ... contributors to diseases of the diabetic foot. The American Board of Multiple ...
(Date:12/1/2015)... IL (PRWEB) , ... December 01, 2015 , ... ... keeping their independence is everything. That is why Hollister Incorporated has launched the ... to offer this next product in the VaPro touch free catheter portfolio,” said ...
(Date:12/1/2015)... ... December 01, 2015 , ... ... has been selected as a finalist in this year’s Fierce Innovation Awards: Healthcare ... IT Healthcare was recognized as a finalist in the category of Digital Solutions ...
(Date:12/1/2015)... ... 2015 , ... TCS Healthcare Technologies (TCS), a leading provider ... is pleased to announce that VIP Care Services, a Caprock Health Group affiliate ... Complete Care™ Management to back their collaborative catastrophic case management initiatives. ACUITY Complete ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... 2015 /PRNewswire/ -- Royal Philips  (NYSE: ... X-ray imaging software that produces high-contrast images for all ... a grid, at the 2015 Radiological Society of ... is Philips, first digital imaging solution providing grid-like contrast ... clinician,s workflow and supports "first-time-right imaging" by decreasing the ...
(Date:12/1/2015)... PUNE, India , December 1, 2015 ... new market research report "Immunotherapy Drugs Market by Type of ... Vaccines), Checkpoint Inhibitors), Epidemiology, Regulatory and Pipeline Analysis - Global ... Market is poised to reach USD 73,529.2 Million by 2020 ... 12.8% from 2015 to 2020. Browse ...
(Date:12/1/2015)... MASON, Ohio , Dec. 1, 2015 /PRNewswire/ ... enhancement to its GeneSight® Psychotropic test giving healthcare providers ... make medication decisions for patients suffering from depression, ... and other behavioral health conditions. ...   --> With the addition of ...
Breaking Medicine Technology: