Navigation Links
First Treatment to Directly Target Tumor Blood Supply

For the first time, physician-scientists at NewYork-Presbyterian Hospital/Weill Cornell Medical Center in New York City have demonstrated// in patients the ability of an antibody to directly target the blood supply of a wide variety of tumors, leaving healthy tissues unharmed.

The Phase I clinical trial tested an antibody called J591, targeted to the prostate specific membrane antigen (PSMA).

PSMA has been an attractive target for cancer drug development because it is not only present in high amounts in prostate cancers but it also is the only known molecular target present on tumor blood vessels but not normal blood vessels. The ability to target PSMA on blood vessels would provide a way to directly attack a tumor’s blood supply without affecting normal blood vessels.

"Anti-angiogenic" cancer therapies that focus on the tumor's blood supply are not new. However, other such treatments starve tumors of their blood supply indirectly, by reducing blood vessel growth signals. J591 may work in a new way, taking anti-angiogenic therapy to the next level by directly targeting PSMA on the cells of the tumor blood vessels and then zooming in for the kill.

The trial, which appears in the Feb. 10 issue of the Journal of Clinical Oncology, involved 27 cancer patients with a wide range of solid tumors -- including kidney, bladder, lung, breast, colorectal, pancreas and melanoma. All patients had widespread disease that had failed conventional treatments.

"Prior to this trial, we had laboratory data that indicated PSMA was present on tumor but not normal blood vessels," explains the study's senior author, Dr. Neil H. Bander, a urological cancer specialist at NewYork-Presbyterian/Weill Cornell and the Bernard and Josephine Chaus Professor of Urological Oncology at Weill Cornell Medical College. "We hypothesized that we could use an antibody to PSMA to specifically target tumor blood supply. This was a proof-of-principle t
'"/>




Page: 1 2 3

Related medicine news :

1. First Vaccine Designed for Africa Cleared for Testing in Humans
2. Ajanta Launches Worlds First Once-A-Day Nimesulide Oral Formulation
3. First human clone is near
4. First Artificial Heart patient has Major setback
5. First head-to-head trials of once weekly Fosamax and Actonel therapies
6. WHO Declares Vietnam First Country to Control SARS
7. Russia Reports First SARS Case
8. Hope for First New Melanoma Treatment in Decades
9. First global SARS meet opens
10. Stanford Medical Center Implements The First Virtual Cardiac Ultrasound
11. Hyderabad To Have Asia’s First Catheter Making Uni
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: First Treatment Directly Target Tumor Blood Supply

(Date:7/11/2014)... new study challenges the widely held belief that light drinking ... analyzed more than 50 studies that examined drinking habits and ... that those with a form of a gene tied to ... affects how a person,s body breaks down alcohol, resulting in ... variant has been shown to lead to lower drinking over ...
(Date:7/11/2014)... Recent research findings regarding Fourth Phase Water are ... water affects human bodies. That was the conclusion of the ... on the Sharon Kleyne Hour Power of Water radio show ... PhD, is a Professor of Bioengineering at the University of ... (Ebner & Sons, 2013). , “Fourth Phase Water,” ...
(Date:7/11/2014)... Alliance Labs announced that they will ... Ed Begley Jr, airing later this year 2014, via ... this episode, Innovations will explore DocuSol® Kids, a mini-enema ... polyethylene glycol base designed to give adolescents general constipation ... as a hyperosmotic laxative by drawing water into the ...
(Date:7/11/2014)... Re-tearing a repaired knee Anterior Cruciate Ligament ... being presented today at the American Orthopaedic Society for ... identification and patient education regarding modifiable risk factors may ... , “Our research suggests that a few risk factors ... utilized may point to the possibility of re-injury,” said ...
(Date:7/11/2014)... SEATTLE, WA Re-tearing a repaired knee Anterior Cruciate ... study being presented today at the American Orthopaedic Society ... and patient education regarding modifiable risk factors may minimize ... "Our research suggests that a few risk factors such ... may point to the possibility of re-injury," said lead ...
Breaking Medicine News(10 mins):Health News:A Little Alcohol May Not Be Good for Your Heart After All 2Health News:Recent Fourth Phase Water Discoveries Alter Basic Understanding of Life, Claims Researcher on Sharon Kleyne Hour 2Health News:Recent Fourth Phase Water Discoveries Alter Basic Understanding of Life, Claims Researcher on Sharon Kleyne Hour 3Health News:Alliance Labs & DocuSol® to be Featured in Upcoming Episode of Innovations 2Health News:New Study May Identify Risk Factors for ACL Re-injury 2
... are soul sisters, says University of Illinois professor Constance ... pregnant and deliver babies that become the center of ... feel defeated and alone. Shapiro,s new book When ... that by providing a sisterhood of survivors who have ...
... more easily diagnosed and that its effects may be more ... in The FASEB Journal ( http://www.fasebj.org ), scientists ... and have discovered that drugs which affect the methylation state ... of drug is already being used in some cancer treatments. ...
... and shampoos, for instance, to breast development, , THURSDAY, ... in a wide range of consumer products may lead ... their risk for health problems later in life, U.S. ... -- phenols, phthalates and phytoestrogens -- are known as ...
... , ... is a great travel booking website for the vacationer who plans in advance, looking for ... a last-minute specials and deals. , ... Los Angeles, CA (PRWEB) April 8, 2010 -- SVH Tours & Travel, a ...
... prescription drugs , THURSDAY, April 8 (HealthDay News) -- Medical ... included -- are poorly informed about herbal medicines and that ... misplaced, according to a new survey. , The survey was ... and Therapeutics Bulletin , which published the results online April ...
... Thomas Mower Sr., Chairman of ... in the growth and success of Sportsmen for Fish and Wildlife (SFW), according to Founder Don ... Salt Lake City (PRWEB) April ... of the Utah Jazz, have been key players in the growth and success of Sportsmen for ...
Cached Medicine News:Health News:The Scarlet I: Infertility survivors lend voices to U of I prof's new book 2Health News:New study of autism reveals a 'DNA tag' (methylation) amenable to treatment 2Health News:Chemicals in Beauty Products Tied to Early Puberty in Girls 2Health News:Agency Pioneer SVH Tours & Travel Launches AppleSpecials.com, New Travel Booking Web Site that Showcases First-Hand Videos and Last Minute Specials 2Health News:Agency Pioneer SVH Tours & Travel Launches AppleSpecials.com, New Travel Booking Web Site that Showcases First-Hand Videos and Last Minute Specials 3Health News:Insight on Herbals Eludes Doctors, Patients Alike 2Health News:Thomas E. Mower And Karl Malone Instrumental To Success Of Sportsmen For Fish And Wildlife Organization 2Health News:Thomas E. Mower And Karl Malone Instrumental To Success Of Sportsmen For Fish And Wildlife Organization 3Health News:Thomas E. Mower And Karl Malone Instrumental To Success Of Sportsmen For Fish And Wildlife Organization 4
(Date:7/11/2014)... , July 11, 2014 Research ... addition of the "Immunoprotein Diagnostic Testing Market ... the highest CAGR of 6% and is expected ... report to their offering. ... immunoprotein diagnostic testing has been segmented according to ...
(Date:7/11/2014)... July 11, 2014 ... Safety & Health Expo 2014 were a ... to London , plus ... exhibition.          (Logo: ... )      (Photo: ...
(Date:7/10/2014)...  Major advances in radiation therapy and radiosurgery ... in a three-day Oncology Summit taking place in ...  Renowned national and international cancer experts from seven countries ... knowledge on modern technologies making treatment for cancer ... The Summit will address a wide spectrum ...
Breaking Medicine Technology:Immunoprotein Diagnostic Testing Market - Forecasts to 2019: Expected to grow at the highest CAGR of 6% and is expected to be valued at USD 4,943.0 million 2UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 2UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 3UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 4Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5
... July 28 HemaQuest Pharmaceuticals, a clinical stage ... disease, beta thalassemia and EBV-related cancers, announced today the ... Series B financing by new investor, Latterell Venture Partners. ... $16M . The financing is intended to help ...
... DIEGO , July 27, 2010 Amylin Pharmaceuticals, Inc. (Nasdaq: ... MAC: Management Access Conference in New York on Tuesday, August ... PT .   Alex Casdin , vice president, finance of Amylin ... , , ...
Cached Medicine Technology:HemaQuest Pharmaceuticals Raises Additional $4M to Bring Total to $16M in Series B Financing 2Amylin Pharmaceuticals to Present at the Wedbush Life Sciences Conference 2010 2
Full automatic, ready-to-use strip washer....
MultiWash Advantage is a versatile microplate washer engineered for reliability. It is designed for lab environments to help streamline their daily processes....
Synchron Hemoglobin A1c (HbA1c) utilizes two unique cartridges, Hb and A1c, to determine HbA1c concentration as a percentage of total hemoglobin....
... HbA1c Testing , Monoclonal antibody ... precision , Correlation study shows 99% agreement ... you can count on a CV ... , National Glycohemoglobin Standardization Program (NGSP) certified ...
Medicine Products: