Navigation Links
Finnish research: Cysteine Chewing Gum as a cure for cancers of the mouth

According to a Finnish research it was found that amino acid, l-cysteine can prevent oral cancers. In the developed countries about 80 % of the cancers occur// in the mouth, pharynx and oesophagus. The main causative agent is smoking and alcohol drinking. This results in a strong exposure of the upper digestive tract to acetaldehyde which causes cancer. The research group of Professor Mikko Salaspuro, University of Helsinki and Helsinki University Hospital, Finland, published already in 1990s a hypothesis, that microbes representing normal human digestive tract flora produce locally acetaldehyde from ethanol and that this may expose them for an increased risk of digestive tract cancers.

The hypothesis was strongly supported by Japanese studies showing that digestive tract cancer risk is markedly increased in Japanese drinkers, who have a decreased ability to remove acetaldehyde because of a gene mutation. The cause and effect relationship was subsequently strongly supported by a novel finding of the Finnish research group showing that after a small dose of alcohol Asians with the above mentioned gene mutation have 2-3 times higher concentrations of acetaldehyde in their saliva than those with the normal acetaldehyde removing enzyme.

Most recently, a research group from NIH reported a mechanism that induces DNA-damage in those acetaldehyde concentrations that are found in the saliva after drinking of alcohol. It has been known already for decades that a harmless aminoacid l-cysteine is able to bind effectively acetaldehyde and thereby eliminate its toxicity. On this basis professor Salaspuro and professor Martti Marvola, University of Helsinki, started to develop l-cysteine containing and acetaldehyde eliminating preparations that eventually could be used for the prevention of digestive tract cancers.

The first two preparations were slowly l-cysteine releasing tablets that effectively eliminated acetaldehyde derived to the mouth and sal iva either after a challenge of alcohol or during smoking. The methods developed by the research groups of Salaspuro and Marvola have been patented world wide. The owner of the patents is nowadays Finnish company Biohit Oyj. The first commercial product based on this patented method is l-cysteine containing chewing gum that was launched on the market in the 11th International Congress of Oral Cancer on May 14-17, in Italy. ‘We know that with this chewing gum it is possible to eliminate acetaldehyde totally from the saliva during smoking.

We do hope that this will in the future turn out to be a novel method for the prevention of alcohol and tobacco smoking associated oral cancers. However, long term randomised controlled trials are naturally needed before the possible cancer preventive effects can be proved. We are currently planning that type of studies’, says Salaspuro. With the saliva carcinogenic acetaldehyde is distributed after swallowing to the pharynx, oesophagus and stomach. Consequently, the effects of l-cysteine may extend to the whole upper digestive tract area.

On the other hand, carcinogenic acetaldehyde can be produced also endogenously by the oral microbes from various foodstuffs with high sugar or carbohydrate content, especially in an achlorhydric stomach. Atrophic gastritis and achlorhydria are well known risk factors of gastric cancer. Therefore, in addition to the chewing gum, also other cysteine containing preparations are under development. The goal is to develop new products releasing slowly cysteine in different parts of the gastrointestinal tract by which acetaldehyde can be eliminated not only in the mouth but also in the stomach and may be also in the large intestine.

Source: Eurekalert

Related medicine news :

1. Chewing gum found to increase brainpower
2. An unlikely contender for speedy surgery recovery: Chewing gum
3. Bihar Banned Tobacco Chewing In State Assembly
4. Obesity Passed Onto Children By Ancestors Smoking And Chewing Betel Nuts
5. A Chewing Gum That Helps in Fighting Tooth Decay
6. Vitamin B12 can help in detecting cancers
7. Antidepressants come in handy for patients on treatment for hepatitis, cancers and multiple sclerosis
8. Exercises reduce risks of cancers
9. Liver cancers which spread are linked to a particular gene
10. Compound from cottonseed for neck and head cancers
11. Expandable metal stents used in digestive cancers
Post Your Comments:

(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed ... geared towards children of all ages; it is a non-competitive, non-timed event, which is ...
(Date:10/13/2017)... ... 2017 , ... “America On The Brink”: the Christian history of the United ... the creation of published author, William Nowers. Captain Nowers and his wife, Millie, ... spent thirty years in the Navy. Following his career as a naval aviator ...
(Date:10/12/2017)... PALM CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... of cold therapy products, announced today the introduction of an innovative new design of ... the multipurpose pad so you get maximum comfort while controlling your pain while using ...
(Date:10/12/2017)... PA (PRWEB) , ... October 12, 2017 , ... ... is the recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B ... York City on October 11, 2017. , The annual award competition recognizes editorial and ...
(Date:10/12/2017)... ... October 12, 2017 , ... In the United States, ... In some states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the ... have extremely low property-tax rates, which contributes to the relatively lower cost of ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)...  EpiVax, Inc., a leader in the fields ... announced the launch of EpiVax Oncology Inc., a ... cancer vaccines. EpiVax has provided $500,000 in seed ... technologies to the new precision immunotherapy venture. Gad ... as Chief Executive Officer. Gad brings over 25 ...
(Date:9/22/2017)... ROCKVILLE, Md. , Sept. 22, 2017  As ... by Republican Senators Bill Cassidy (R-LA) and ... Kalorama Information notes that the medical device industry is ... the medical device tax, the 2.3% excise tax on ... Act.  But they also want covered patients, increased visits ...
(Date:9/19/2017)... HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, platform ... leadership team developments today:   ... ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has led ...
Breaking Medicine Technology: