Navigation Links
Finasteride lowers risk of prostate cancer but increases risk of high-grade tumors

Finasteride prophylaxis appears to prevent or delay the onset of prostate cancer, however, finasteride may also accelerate the growth of high-grade cancers.
More than 18,000 men were randomized , age 55 or older to finasteride 5 mg/day or placebo. At baseline, digital rectal examination results were normal in all subjects, and prostate-specific antigen (PSA) levels were no more than 3.0 ng/mL. Among the 4368 men in the finasteride group treated for 7 years,// prostate cancer was detected in 18.4%, compared with 24.4% of the 4692 assigned to placebo group, a significant difference (p < 0.001). Tumors of Gleason grade 7, 8, 9, or 10 occurred in 37.0% of the graded tumors in the finasteride group and 22.2% of those in the placebo group (p = 0.005). Five men in each group died from prostate cancer.

Treatment was temporarily discontinued by 18.3% of subjects administered finasteride and 9.8% of those given placebo because of side effects. Finasteride was more likely to affect sexual functioning, whereas placebo was more likely to be associated with genitourinary effects.

For a man considering using this medication, the greater absolute reduction in the risk of prostate cancer must be weighed against the smaller absolute increase in the risk of high-grade disease,say doctors.

Researchers, suggests that "finasteride may have created an environment in which high-grade cancers that were less dependent on androgens for their growth had a competitive advantage."

According to doctors , "Finasteride does not seem to be an attractive agent for the chemoprevention of prostate cancer." However, they do not advocate discontinuation of the drug when used to treat urinary symptoms, so long as patients undergo careful monitoring.
'"/>




Page: 1

Related medicine news :

1. Finasteride lowers risk of prostate cancer but increases risk of high-grade tumors
2. Brisk Walking lowers memory loss in women
3. B Vitamin protects and lowers toxicity of Arthritis Drug
4. Estrogen lowers cancer risk
5. Lecithin lowers cholesterol absorption in body
6. Salt reduction lowers blood pressure
7. Exercise lowers Risk of Ovarian Cancer
8. Fish rich diet lowers leptin
9. Finasteride lowers risk of prostate cancer but increases risk of high-grade tumors
10. A Warning For Western Diet Followers!
11. Smoking lowers chances of surviving throat cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... , ... Marcy was in a crisis. Her son James, eight, was out of control. Prone ... physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If ... at my other children and say he was going to kill them. If we ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. ... magazine’s Code Talker Award, an essay contest in which patients and their families pay ... be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Investment Group (TGIG), has initiated cultivation and processing operations at its production facility, ... Pahrump, Nevada. , Puradigm is the manufacturer of a complete system of proactive ...
(Date:6/24/2016)... ... , ... Venture Construction Group (VCG) sponsors Luke’s Wings ... the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event ... that have been wounded in battle and their families. Venture Construction Group is a ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... Analysis 2016 - Forecast to 2022" report to their ... contains up to date financial data derived from varied research ... trends with potential impact on the market during the next ... which comprises of sub markets, regional and country level analysis. ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... offering. The current unmet ... for MedImmune to enter. The US ageing population creates a ... considerable growth for effective anti-influenza medications. The introduction of a ... development is still in its infancy. Key ...
(Date:6/23/2016)... MOUNTAIN VIEW, Calif. , June 23, 2016 ... 9:00 a.m. CST on Thursday, July 7, 2016 , , ... kayla.belcher@frost.com ) , , , , EXPERT PANELISTS:  ... Sciences, Nitin Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, ... The global pharmaceutical industry is witnessing ...
Breaking Medicine Technology: