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Finally, The First Ever Treatment for Drug-Resistant HIV

Doctors can now boast of their first FDA-approved pill capable of treating drug-resistant HIV, which is possible only due to the creation// of a new molecule by a researcher from Purdue University. The molecule, identified by the name TMC-114, and also known by the name of Darunavir, leads the list of a series of molecules that are still under creation by Arun Ghosh, a professor with a dual appointment in the departments of chemistry and medicinal chemistry and molecular pharmacology.

Arun Ghosh said, "There are many treatments for AIDS on the market, but none are able to combat drug resistance. This is the first treatment that is effective against the growing number of drug-resistant strains of HIV, the virus that causes AIDS. The problem is widespread."

Earlier research shows that almost half of patients with the human immunodeficiency virus (HIV) who initially respond to treatment develop drug-resistant strains and stop responding to treatment within eight to 10 months, he said. An additional 20 percent to 40 percent of patients have drug-resistant strains when they are first diagnosed, suggesting these strains can be transmitted from one person to the next.

This year marks the 25th anniversary of the first reported U.S. cases of AIDS, a disease that claims the lives of more than 15,000 Americans each year, according to the Centers for Disease Control and Prevention. World Health Organization figures estimate more than 40 million people worldwide are infected with HIV.

For years the virus has frustrated drug developers through its ability to "outsmart" therapies. The virus rapidly mutates and, as parts of its structure change, it becomes resistant to treatment. Previously, patients with drug-resistant strains were out of options and had greatly reduced life expectancies.

"My only wish was that my design would help people and alleviate suffering," Ghosh said. "I'm so grateful it has turned into a dru
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