Navigation Links
Filling a Niche -- Role of Rb in Mammalian Stem Cells

Drs. Gustavo Leone and Michael Robinson (Ohio State University) and colleagues uncover a stem-cell specific role for the well-known tumor suppressor gene// , Rb, in the developing mammalian embryo.

Researchers had previously shown that mice deficient in Rb die as embryos. Using a combination of sophisticated mouse genetics and 3D computer modeling, OSU scientists have now determined why: Rb is required for the maintenance of the trophoblast stem cell population, which is essential for forming the placenta. Specific loss of Rb in trophoblast stem cells results in an overexpansion of trophoblast cells, aberrant placental formation, and embryonic death.

These findings implicate a role for the Rb pathway in the development of the human placenta and may provide a link between Rb, and possibly other cell cycle regulators, and pregnancy-related complications such as miscarriages and pre-eclempsia.

The demonstration that Rb tumor suppressor function is critical in trophoblast stem cells of the placenta will also certainly fuel the emerging hypothesis that stem-like cells may serve as a repository in which tumor suppressor function is critical to prevent cancer.

Source-Eurekalert
'"/>




Page: 1

Related medicine news :

1. Safety Of Dental Amalgam Fillings To Be Reviewed
2. First Major Study of Mammalian “Disorderly” Proteis
3. Cannibalistic Signals Help Mammalian Embryos Develop Normally
4. Blood Cells Capable of Regenerating Liver
5. White Cells Count Can Predict Heart Attack Death Risk
6. Gene Therapy Destroys Pancreatic Cancer Cells
7. Stem Cells Have Few Mutations
8. Heart may pull Cells from Body to Self-repair
9. Cells critical for asthma development found
10. Vitamin D Wipes out Cancer Cells
11. Bone Marrow Cells Help Heart Attack Patients
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/16/2017)... ... , ... California Southern University has named Dr. Steven Beazley University President. ... as a core faculty member, teaching master’s and doctoral courses in the university’s School ... University, where he earned his Doctor of Psychology degree in 1998. Dr. Beazley also ...
(Date:1/16/2017)... ... , ... With the Grand Opening Event planned for February 3, 2017, the ... and the general public. Built in five months by Centerpoint, the 60,000 square foot ... or pickleball courts. The space is also suitable for indoor soccer and football training. ...
(Date:1/16/2017)... New York (PRWEB) , ... January 16, 2017 ... ... SightMD today announced the addition of Victor Giamos, MD to their ... of SightMD and Managing Partner at North Shore Eye Care, a division of ...
(Date:1/16/2017)... ... January 16, 2017 , ... ... partnership with an innovator in the wheelchair accessibility industry, BraunAbility . Incentive ... salespeople to sell wheelchair accessible vehicles. With this new incentive plan, BraunAbility plans ...
(Date:1/16/2017)... ... January 16, 2017 , ... Board-certified oculoplastic surgeon ... , the official journal of The American Society for Aesthetic Plastic Surgery, in ... procedure is designed to correct drooping, retracted lower eyelids, which usually result from ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... BAUDETTE, Minn. , Jan. 17, 2017 /PRNewswire/ ... ) today announced the appointment of Karen Quinn ... January 17, 2017.  Karen ... years of leadership experience in Global Regulatory Affairs, ... biologically-derived active pharmaceutical ingredients.  Dr. Quinn worked most ...
(Date:1/17/2017)... pioneer in no-touch UV disinfection has now been validated by ... for "total room ultraviolet disinfection," was the device of choice ... study which was recently published in The Lancet ... transmission of four major superbugs by a cumulative 30 percent. ... we have been committed to innovation and the science behind ...
(Date:1/16/2017)... Research and Markets has announced the addition ... to their offering. ... Global multiple myeloma drugs market to grow at a CAGR ... covers the present scenario and the growth prospects of the global ... the report considers the revenue generated from the sales of branded ...
Breaking Medicine Technology: