Navigation Links
Filling a Niche -- Role of Rb in Mammalian Stem Cells

Drs. Gustavo Leone and Michael Robinson (Ohio State University) and colleagues uncover a stem-cell specific role for the well-known tumor suppressor gene// , Rb, in the developing mammalian embryo.

Researchers had previously shown that mice deficient in Rb die as embryos. Using a combination of sophisticated mouse genetics and 3D computer modeling, OSU scientists have now determined why: Rb is required for the maintenance of the trophoblast stem cell population, which is essential for forming the placenta. Specific loss of Rb in trophoblast stem cells results in an overexpansion of trophoblast cells, aberrant placental formation, and embryonic death.

These findings implicate a role for the Rb pathway in the development of the human placenta and may provide a link between Rb, and possibly other cell cycle regulators, and pregnancy-related complications such as miscarriages and pre-eclempsia.

The demonstration that Rb tumor suppressor function is critical in trophoblast stem cells of the placenta will also certainly fuel the emerging hypothesis that stem-like cells may serve as a repository in which tumor suppressor function is critical to prevent cancer.

Source-Eurekalert
'"/>




Page: 1

Related medicine news :

1. Safety Of Dental Amalgam Fillings To Be Reviewed
2. First Major Study of Mammalian “Disorderly” Proteis
3. Cannibalistic Signals Help Mammalian Embryos Develop Normally
4. Blood Cells Capable of Regenerating Liver
5. White Cells Count Can Predict Heart Attack Death Risk
6. Gene Therapy Destroys Pancreatic Cancer Cells
7. Stem Cells Have Few Mutations
8. Heart may pull Cells from Body to Self-repair
9. Cells critical for asthma development found
10. Vitamin D Wipes out Cancer Cells
11. Bone Marrow Cells Help Heart Attack Patients
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... June 27, 2016 , ... The OSHA Training ... Institute Education Center headquartered in Northern California, has issued an important reminder to ... their worksites. Employers with workers exposed to high temperatures should establish a ...
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... "FCPX editors ... customizable inside of Final Cut Pro X," said Christina Austin - CEO of Pixel ... style. Final Cut Pro X users can now reveal the media of ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... health professionals, announced today its affiliation with Tennessee Counseling Association. This ... the network of the Tennessee Counseling Association, adding exclusive benefits and promotional offers. ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... industry today announced its strategic partnership with Connance, a healthcare industry leader ... two companies’ proven, proprietary technology combine to provide health systems, hospitals and ...
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... transport experience for the millions of people who require these medical transport services ... industry through the use of technology. Now, SmartEMS has put forth an industry-changing ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...   Bay Area Lyme Foundation , collaborating ... for Tick Borne Illness , Harvard Medical School ... Medicine, University of California, Berkeley, and the Veterans ... finalists of Lyme Innovation , the first ... scientists, clinicians, researchers, entrepreneurs, and investors from several ...
(Date:6/24/2016)... 2016 Research and Markets ... Electronics 2015-2025: Applications, Technologies, Forecasts" report to ... In-Mold Electronics, Smart Skin, Structural Health Monitoring, Composite ... Structural electronics involves electronic and/or electrical components and ... dumb structures such as vehicle bodies or conformally ...
(Date:6/24/2016)... 2016 Dehaier Medical Systems Ltd. (NASDAQ: ... markets and sells medical devices and wearable sleep respiratory ... strategic cooperation agreement with Hongyuan Supply Chain Management Co., ... June 20, 2016, to develop Dehaier,s new Internet medical ... Dehaier will leverage Hongyuan Supply Chain,s sales platform to ...
Breaking Medicine Technology: