Navigation Links
Fibrinogen may Inhibit Spinal Cord Regeneration

Fibrinogen, a blood-clotting protein found in circulating blood, has been found to inhibit the growth of central nervous system neuronal cells , a process that is necessary for the regeneration of the spinal cord after traumatic injury.

The findings by researchers at the University of California, San Diego (UCSD) School of Medicine, may explain why the human body is unable to repair itself after most spinal cord injuries.

The study, led by Katerina Akassoglou, Ph.D., assistant professor in UCSDs Department of Pharmacology, is the first evidence that when blood leaks into the nervous system, the blood protein contributes to the neurons inability to repair themselves.

The findings, which show the molecular link between vascular and neuronal damage during injury to the central nervous system, was published in the online issue of the Proceedings of the National Academy of Sciences on July 2.

The research team studied three types of spinal cord injuries in mice and rats which resulted in cellular and vascular damage, and leakage of fibrinogen from the blood vessels.

Once injured, neurons cannot be repaired because of various inhibitors that are present in the brain and the spinal cord after damage, which results in a patients paralysis. The researchers were surprised at the massive deposits of fibrinogen found at the sites of injury. That discovery led them to investigate the proteins effect on neuronal cells ability to regenerate.

Our study shows that fibrinogen directly affects neurons by inhibiting their ability for repair, said Akassoglou. Fibrinogen contained in the blood which leaks at the site of injury begins the process of inhibiting axonal growth by binding to the beta 3 integrin receptor.

This binding, in turn, induces the activation of another receptor on the neuronal cells, called the epidermal growth factor receptor. When the second receptor is activated, it inhibits the axonal growth. Other inhibitors have been identified that use the same epidermal growth factor receptor, but this is the first blood-derived inhibitor that has been found.

The discovery may open the door to a possible strategy to improving recovery after spinal cord injury by discovering a way to block activation of neuronal receptors by fibrinogen.

Identifying the specific inhibitors that impede the repair process could provide ways to regenerate and connect the damaged nerves and initiate recovery from paralysis after spinal cord injury.

Inhibiting the damaging effects of fibrinogen on neurons may potentially facilitate repair in the nervous system after injury said Akassoglou.

A similar mechanism could be at work in other neurological diseases that result in paralysis, such as multiple sclerosis or hemorrhagic stroke, where blood vessels break and bleed into the brain. She added that such a therapeutic approach wouldnt interfere with fibrinogens essential role in coagulation, because its blood-clotting mechanism depends on binding with a different receptor.


'"/>




Related medicine news :

1. Tomatoes Might Inhibit the Development Of Prostate Cancer
2. Identified Protein To Inhibit Cell Migration
3. Aromatase Inhibitors drug Femara after Tamoxifen therapy protects from breast cancer recurrence
4. Omega 3 Fatty acids (fishy oil) Inhibits Breast Cancer Growth
5. Macrophage Inhibitory Factor Causes Multiple Sclerosis Progression
6. Inhibition of morphine tolerance by spinal melanocortin receptor blockade
7. Sugars Could Contain Key Cancer Inhibiting Compounds
8. Rejuvenation of Stem cells by GSK-3 Inhibitor
9. Anonymity Helps In Overcoming Inhibitions During Online Counseling
10. LipB Protein Inhibitors Help To Fight Against TB
11. Birth Defects Link With ACE Inhibitor Use, FDA Reports
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)... Richmond, VA (PRWEB) , ... March 29, 2017 , ... ... of its seventh North American office location in Richmond, Virginia, located at the Riverfront ... April 11, attended by Lieutenant Governor of Virginia Ralph S. Northam and Mayor of ...
(Date:3/28/2017)... ... , ... For many women, getting birth control isn’t as easy as it should be. In ... access to a health care facility or a pharmacy within 60 minutes of where they ... or for many who are faced with health or personal issues that leave them homebound. ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... state legislatures and Congress to protect parental rights and civil liberties, and to ... in America. , The demonstration coincides with a press conference taking place Friday ...
(Date:3/28/2017)... , ... March 28, 2017 , ... ... software and services, is proud to announce it has joined the National Association ... representing the interests of chronically ill, disabled, and dying Americans of all ages ...
(Date:3/28/2017)... ... March 28, 2017 , ... Z-Medica, ... University of Pittsburgh Medical Center (UPMC) will acquire QuikClot® Bleeding Control Kits® (BCK) ... program, developed in association with efforts by the American College of Surgeons, U.S. ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... March 29, 2017  The Pharmaceutical Care Management Association ... PhRMA report on patient out-of-pocket spending: ... Medicaid Services (CMS), the average amount spent out-of-pocket for ... drug spending in 2016, down from 23% in 2006. ... problem, not a coverage problem. Health plans don,t have ...
(Date:3/29/2017)... , March 29, 2017  Designers of primary ... reduce solution size by 50% and extend battery life ... power management integrated circuit (PMIC) from Maxim Integrated Products, ... supports a low input voltage of just 0.7V for ... and Silver Oxide, as well as the more common ...
(Date:3/29/2017)... , March 29, 2017   Royal ... leader in health technology, and PathAI, a company ... collaborating with the aim to develop solutions that ... of cancer and other diseases. The partnership aims ... enabling this form of artificial intelligence to be ...
Breaking Medicine Technology: