Navigation Links
Fetal Neural Grafts Improves Motor and Cognitive Function in Huntington Patients

Anne-Catherine Bachoud-Lévi, M.D., and colleagues of the French national institute of health and medicine reported in The Lancet that Huntington's disease// who previously received intracerebral fetal neural grafts had improvements in both motor and cognitive function.

But the same investigators reported today that the improvements in Huntington's disease patients plateaued after two years and then began to decline over the next two to four years, with consistent worsening of dystonia but not chorea.

The patient’s cognitive performance remained stable on non-timed tests, but worsened on timed tests, indicating continued loss of motor function.

In this intracerebral cell therapy the investigators grafts replacement striatal neuroblasts and neural precursor cells obtained from electively aborted fetuses into the brains of patients with Huntington's disease.

Even after a year the transplanted cells did not have any signs of typical Huntington's neuropathology but they do not affect the disease progression in the native cells carrying the mutant huntingtin gene.

In this pilot study the five participants were followed for up to six years after neural graft surgery. The patients were assessed annually with the unified Huntington's disease rating scale, neuropsychological tests, and MRI. It showed that three of the five patients in the first two years were marked by progressive clinical improvement, followed by a period of stabilization, and then gradual decline. On the other hand the remaining two patients had no lasting clinical benefits of improvement in brain function.

It was found that one patient continued to work part time for six years, and all three patients were able to do activities they had lost before the surgery but regained afterward, such as cycling or doing odd jobs around the house like cycling and guitar playing. But these activities were lost again after five years. At the end of the study a ll three patients were able to set the table, cook by themselves, and wash dishes.

It was also noted that the brain activity in frontal and prefrontal cortices improved. But the disease continued to spread to other parts of the brain.

Dr. Bachoud-Lévi and colleagues said that the disease has the ability to spread to regions such as the neocortex and hence replacement of striatal neurons will help delay but not stop disease progression. In conclusion the researchers said that the molecular mechanism of neuronal death is unavoidable in Huntington's disease. In the future various studies that combine both neuroprotection and neuronal replacement have to be developed. This is because Neuro-protection could stop the disease, but only a graft can restore lost function.

'"/>




Related medicine news :

1. Fish Found To Improve Fetal Growth
2. Fetal Cell Transplant Found To Improve Movement In Patients With Parkinson’s Disease
3. Vitamin Supplements During Pregnancy to Boost Fetal Development
4. Worried About The Sensitive Skin Of Your 2 Year Old? Fetal Skin Cells To Offer Help
5. Using Eyes As The Line Of Reference For Fetal Brain Imaging
6. Simple Eye Movement Test For Early Detection Of Fetal Alcohol Spectrum Disorder
7. Genetic Disorders, Not Fetal Distress Increase Cerebral Palsy Risk
8. Fetal Development Face The Threat By Frequent Ultrasounds
9. New Drug Could Prevent Fetal Alcohol Syndrome
10. Epilepsy Drug Poses High Risk for Fetal Death and Birth Defects
11. Americans Deficient In Dietary Intake Of Choline Needed for Fetal Brain Development
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/5/2016)... ... May 05, 2016 , ... Michael Lanteri Agency ... created to assist the people of their local community. The agency pledges to ... community leaders. Their hope is to bring awareness to important local causes with ...
(Date:5/5/2016)... ... , ... Vitenas Cosmetic Surgery has been named as one of the eight ... Architects and the Academy of Architecture for Health. The building, brainchild of founder Paul ... patients in October of 2014. , The prestigious Healthcare Design Awards ...
(Date:5/5/2016)... ... May 05, 2016 , ... Sun ... talk highlighting the organization’s successful Care Transitions program at the 9th ... was titled “Minimizing Costs in the Post-Acute Environment Through Effective Transitions of Care.” ...
(Date:5/5/2016)... ... 05, 2016 , ... When stiff and achy joints are ... pain that’s a common osteoarthritis (OA) symptom. Yet, numerous clinical studies point to ... , “Physical therapy exercises are commonly prescribed to individuals with osteoarthritis as ...
(Date:5/5/2016)... ... May 05, 2016 , ... T.E.N., a technology and information ... 3, at the 2016 ISE® Central Executive Forum and Awards Gala at the ... Security Officer of HMS, was selected as the Information Security Executive® of the ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... May 3, 2016 BioNovus Innovations LLC ... for Advancing Medical Innovation (IAMI) today announced a ... diagnostics and medical devices. An agreement ... rights to license, develop and commercialize medical innovations ... "This partnership represents a significant advance in ...
(Date:5/3/2016)... TUCSON, Ariz. , May 3, 2016  As ... twice contracted rheumatic fever, which damaged his heart. ... But by June 2013, Shepherd,s heart was ... days from death. On June 20, 2013, the ... temporary Total Artificial Heart (TAH-t). Like a heart transplant, ...
(Date:5/3/2016)... watching a film or TV show in high definition, you may not be familiar with ...  is a renowned authorized reseller of the medical industry,s top brands as well as a ... ... ... Although initially introduced ...
Breaking Medicine Technology: