Navigation Links
Fetal Neural Grafts Improves Motor and Cognitive Function in Huntington Patients

Anne-Catherine Bachoud-Lévi, M.D., and colleagues of the French national institute of health and medicine reported in The Lancet that Huntington's disease// who previously received intracerebral fetal neural grafts had improvements in both motor and cognitive function.

But the same investigators reported today that the improvements in Huntington's disease patients plateaued after two years and then began to decline over the next two to four years, with consistent worsening of dystonia but not chorea.

The patient’s cognitive performance remained stable on non-timed tests, but worsened on timed tests, indicating continued loss of motor function.

In this intracerebral cell therapy the investigators grafts replacement striatal neuroblasts and neural precursor cells obtained from electively aborted fetuses into the brains of patients with Huntington's disease.

Even after a year the transplanted cells did not have any signs of typical Huntington's neuropathology but they do not affect the disease progression in the native cells carrying the mutant huntingtin gene.

In this pilot study the five participants were followed for up to six years after neural graft surgery. The patients were assessed annually with the unified Huntington's disease rating scale, neuropsychological tests, and MRI. It showed that three of the five patients in the first two years were marked by progressive clinical improvement, followed by a period of stabilization, and then gradual decline. On the other hand the remaining two patients had no lasting clinical benefits of improvement in brain function.

It was found that one patient continued to work part time for six years, and all three patients were able to do activities they had lost before the surgery but regained afterward, such as cycling or doing odd jobs around the house like cycling and guitar playing. But these activities were lost again after five years. At the end of the study a ll three patients were able to set the table, cook by themselves, and wash dishes.

It was also noted that the brain activity in frontal and prefrontal cortices improved. But the disease continued to spread to other parts of the brain.

Dr. Bachoud-Lévi and colleagues said that the disease has the ability to spread to regions such as the neocortex and hence replacement of striatal neurons will help delay but not stop disease progression. In conclusion the researchers said that the molecular mechanism of neuronal death is unavoidable in Huntington's disease. In the future various studies that combine both neuroprotection and neuronal replacement have to be developed. This is because Neuro-protection could stop the disease, but only a graft can restore lost function.

'"/>




Related medicine news :

1. Fish Found To Improve Fetal Growth
2. Fetal Cell Transplant Found To Improve Movement In Patients With Parkinson’s Disease
3. Vitamin Supplements During Pregnancy to Boost Fetal Development
4. Worried About The Sensitive Skin Of Your 2 Year Old? Fetal Skin Cells To Offer Help
5. Using Eyes As The Line Of Reference For Fetal Brain Imaging
6. Simple Eye Movement Test For Early Detection Of Fetal Alcohol Spectrum Disorder
7. Genetic Disorders, Not Fetal Distress Increase Cerebral Palsy Risk
8. Fetal Development Face The Threat By Frequent Ultrasounds
9. New Drug Could Prevent Fetal Alcohol Syndrome
10. Epilepsy Drug Poses High Risk for Fetal Death and Birth Defects
11. Americans Deficient In Dietary Intake Of Choline Needed for Fetal Brain Development
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/21/2017)... ... ... As recently as 2015, rhinoplasty was one of the Top 5 cosmetic ... patients want to make a change in the appearance of their nose while others ... team at usrhinoplasty.org is expanding its article database to better inform its ...
(Date:2/21/2017)... ... 2017 , ... American Veterinarian™, the premier multimedia provider of ... first bi-monthly issue of 2017 in February. The inaugural issue will offer expert ... , In making the announcement, American Veterinarian™ Publisher Chris Hennessy said, “We ...
(Date:2/21/2017)... San Francisco, California (PRWEB) , ... February 21, ... ... in the world with over 50,000 participants. The connected care demonstration spanned ... Office of the National Coordinator, roughly 30% of providers have no Health Information ...
(Date:2/21/2017)... ... February 21, 2017 , ... Along with Valentine’s Day, February marks ... small changes that can lead to a lifetime of heart health. In addition, ... emergency. , The Athletic Trainers’ Society of New Jersey (ATSNJ) is urging ...
(Date:2/20/2017)... ... 20, 2017 , ... Daily Body Restore, "DBR" a company ... “good” bacteria in the body, announced its Daily Body Restore® supplement is now ... Body Restore® is made with a unique combination of digestive enzymes and probiotics ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... 21, 2017 Mass Spectrometer Market: Overview ... This report on mass spectrometer ... prospects of the market globally. The stakeholders of ... the manufacture and commercialization of various mass spectrometer ... planning to enter this market. This report comprises ...
(Date:2/21/2017)... -- Luminex Corporation (NASDAQ: LMNX ) (the "Company") today ... of a quarterly cash dividend to its shareholders, the first ... payable on April 14, 2017 to shareholders of record as ... The board of directors intends for the Company ... holders of its common stock, representing a planned annual dividend ...
(Date:2/21/2017)... Feb. 21, 2017  Global health services company Cigna ... ® for breast reconstruction surgery and Dermacell ... an advanced acellular dermal matrix developed by LifeNet Health ... NVDQ ) "We are proud ... health-care payers to review the growing base of evidentiary ...
Breaking Medicine Technology: