Navigation Links
Fetal Neural Grafts Improves Motor and Cognitive Function in Huntington Patients

Anne-Catherine Bachoud-Lévi, M.D., and colleagues of the French national institute of health and medicine reported in The Lancet that Huntington's disease// who previously received intracerebral fetal neural grafts had improvements in both motor and cognitive function.

But the same investigators reported today that the improvements in Huntington's disease patients plateaued after two years and then began to decline over the next two to four years, with consistent worsening of dystonia but not chorea.

The patient’s cognitive performance remained stable on non-timed tests, but worsened on timed tests, indicating continued loss of motor function.

In this intracerebral cell therapy the investigators grafts replacement striatal neuroblasts and neural precursor cells obtained from electively aborted fetuses into the brains of patients with Huntington's disease.

Even after a year the transplanted cells did not have any signs of typical Huntington's neuropathology but they do not affect the disease progression in the native cells carrying the mutant huntingtin gene.

In this pilot study the five participants were followed for up to six years after neural graft surgery. The patients were assessed annually with the unified Huntington's disease rating scale, neuropsychological tests, and MRI. It showed that three of the five patients in the first two years were marked by progressive clinical improvement, followed by a period of stabilization, and then gradual decline. On the other hand the remaining two patients had no lasting clinical benefits of improvement in brain function.

It was found that one patient continued to work part time for six years, and all three patients were able to do activities they had lost before the surgery but regained afterward, such as cycling or doing odd jobs around the house like cycling and guitar playing. But these activities were lost again after five years. At the end of the study a ll three patients were able to set the table, cook by themselves, and wash dishes.

It was also noted that the brain activity in frontal and prefrontal cortices improved. But the disease continued to spread to other parts of the brain.

Dr. Bachoud-Lévi and colleagues said that the disease has the ability to spread to regions such as the neocortex and hence replacement of striatal neurons will help delay but not stop disease progression. In conclusion the researchers said that the molecular mechanism of neuronal death is unavoidable in Huntington's disease. In the future various studies that combine both neuroprotection and neuronal replacement have to be developed. This is because Neuro-protection could stop the disease, but only a graft can restore lost function.

'"/>




Related medicine news :

1. Fish Found To Improve Fetal Growth
2. Fetal Cell Transplant Found To Improve Movement In Patients With Parkinson’s Disease
3. Vitamin Supplements During Pregnancy to Boost Fetal Development
4. Worried About The Sensitive Skin Of Your 2 Year Old? Fetal Skin Cells To Offer Help
5. Using Eyes As The Line Of Reference For Fetal Brain Imaging
6. Simple Eye Movement Test For Early Detection Of Fetal Alcohol Spectrum Disorder
7. Genetic Disorders, Not Fetal Distress Increase Cerebral Palsy Risk
8. Fetal Development Face The Threat By Frequent Ultrasounds
9. New Drug Could Prevent Fetal Alcohol Syndrome
10. Epilepsy Drug Poses High Risk for Fetal Death and Birth Defects
11. Americans Deficient In Dietary Intake Of Choline Needed for Fetal Brain Development
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A ... 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the ... history as home to some of the world’s leading providers of cereal and other ...
(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... ... to fertility once they have been diagnosed with endometriosis. These women need a ... they also require a comprehensive approach that can help for preservation of fertility ...
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and ... their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took ... the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... June 19, ... the dangers associated with chronic pain and the benefits of holistic treatments, Serenity ... who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 27, 2016  VMS Rehab Systems, Inc. ... will take whatever measures required to build a strong ... which is currently listed on the OTC Markets-pink current ... Chairman and CEO, "We are seeing an anomaly in ... understand, not only by the Company, but shareholders and ...
(Date:6/24/2016)... 24, 2016  Collagen Matrix, Inc., ("Collagen Matrix") ... manufacturing of collagen and mineral based medical devices ... Bill Messer has joined the company ... leverage the growing portfolio of oral surgery, neurosurgery, ... Bill joins the Collagen Matrix executive team as ...
(Date:6/24/2016)... 24, 2016 ... the addition of the " Global Markets for ... This report focuses on ... updated review, including its applications in various applications. The ... which includes three main industries: pharmaceutical and biotechnology, food ...
Breaking Medicine Technology: