Navigation Links
Fatigue After Liver Transplantation Does Not Lessen With Time

Patients who undergoing Liver transplant reportedly experience physical fatigue and reduced activity rather than mental fatigue and reduced motivation//. In a new study on this fatigue experienced by patients after liver transplantation, it was found that to be a major problem that does not seem to improve with the passage of time. The results of this study was published in the June 2006 issue of Liver Transplantation that is the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS). John Wiley & Sons, Inc. publishes the journal for the societies. The same is also available online through Wiley InterScience at 'http://www.interscience.wiley.com/journal/livertransplantation.'

Although fatigue is common in end-stage liver disease and can even contribute to the need for a liver transplant, few studies have been conducted on fatigue after liver transplants take place. In the current study, researchers led by Rita van den Berg-Emons, Ph.D. of the Department of Rehabilitation Medicine at the Erasmus Medical Center in Rotterdam, The Netherlands, assessed 96 liver transplant patients who visited the hospital's outpatient clinic between February and June 2003. The patients were given a series of self-administered questionnaires: the Fatigue Severity Scale (FSS) measured fatigue severity; the Multidimensional Fatigue Inventory (MFI-20) measured the nature of fatigue; two additional questionnaires measured the patients' disability level and their health-related quality of life (HRQoL). In addition, the researchers assessed patients' age, gender, reason for having the transplant, time since the transplant took place, and the number of immunosuppressive agents they were taking.

The results showed that 66 percent of the patients were fatigued, 44 percent were severely fatigued, and there was no indication that fatigue lessened over time. 'This is the first study to provide information on both the severity and nature of fatigue after liver transplantation, and on factors associated with the severity of fatigue,' the authors note. As with a previous study, the patients experienced physical fatigue and reduced activity rather than mental fatigue and reduced motivation. 'These findings imply that fatigue after liver transplantation might be reduced with rehabilitation programs focusing on improving activity patterns and physical fitness,' the authors state. They found a weak relationship between severity of fatigue and gender and age (women experienced more fatigue) and a stronger relationship between self-assessed disabilities and HRQoL. This may be because fatigue may lead to an inactive lifestyle, which in turn may lead to an impaired quality of life. Neither the condition necessitating the transplant nor the number of immunosuppressive agents was associated with the severity of fatigue, the study found.

The authors conclude: 'These findings imply that rehabilitation programs, focusing on improving activity patterns and physical fitness, may reduce complaints of fatigue after liver transplantation. However, the effect of rehabilitation on fatigue has to be established in future research.'

In an accompanying editorial in the same issue, Jayant A. Talwalkar, M.D., M.P.H. of the Division of Gastroenterology & Hepatology at the Mayo Clinic College of Medicine in Rochester, MN notes that while many symptoms of liver disease resolve following transplant, fatigue is one that remains, for reasons as yet unclear. The strengths of the current study, according to the author, are that it used valid instruments to measure fatigue, it confirmed the role of physical function in fatigue, and it described the strong relationship between fatigue and lower HRQoL. However, the findings conflicted with an earlier study in which fatigue was less common in patients four to five years post-transplant. This may be due to resp onse shift, where patients experienced a positive change in attitude after the traumatic experience of surviving the transplant, or it may be due to the lack of a psychological assessment and the role of anxiety/depression in causing fatigue in the current study. Regarding the link between fatigue and reduced physical activity, the author notes that two recent studies on the effects of physical rehabilitation showed positive results on physical fitness and quality of life. However, no studies have been performed so far on effects of physical rehabilitation on complaints of fatigue. The author concludes that 'the time has come to shift gears by identifying efficacious interventions which improve physical function, fatigue, and HRQL in this population,' and suggests that in cases where exercise is ineffective, novel drug therapies may need to be tested and impaired cognitive function may also need to be examined as a possible cause of fatigue.

Source: Eurekalert
'"/>




Related medicine news :

1. Reduced Fatigue Boosts Mental Health
2. Overcoming Chronic Fatigue
3. Chronic Fatigue, Pain Linked to Sinusitis
4. Helping Cancer Patients Fight Fatigue
5. A Sedentary Childhood Could Lead To Chronic Fatigue Latter In Life
6. Obesity And Chronic Fatigue Related To Snoring
7. Fatigue, Prevalent Among Patients Treated For Breast Cancer
8. Persistent Fatigue Could Be An Early Indicator Of Postpartum Depression
9. Brain Injury, A Consequence Of Glandular Fever Could Trigger Fatigue Syndrome
10. Efficacy Of Sports-Formulated Jelly Beans In Warding Off Fatigue To Be Studied
11. Genetics Might BE The Basis For Chronic Fatigue Syndrome
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... 2016 , ... TherapySites, the leading website and ... Tennessee Counseling Association. This new relationship allows TherapySites to continue to extend ... exclusive benefits and promotional offers. , "TCA is extremely excited about this new ...
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their ... Eyeglasses . , Millions of individuals in the United States and Canada wear eyeglasses. ... way to both correct vision and make a fashion statement. Even celebrities use glasses ...
(Date:6/26/2016)... ... ... Pixel Film Studios Released ProSlice Levels, a Media Slicing Effect Plugin ... whole new perspective by using the title layers in ProSlice Levels to split-up ... Levels contains over 30 Different presets to choose from. FCPX users can ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are confused ... endometriosis. These women need a treatment plan to not only alleviate symptoms and ... help for preservation of fertility and ultimately achieving a pregnancy. The specialists at ...
(Date:6/25/2016)... ... 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to a ... new, often overlooked aspect of head lice: the parasite’s ability to live away from a ... occurrence, but a necessary one in the event that lice have simply gotten out of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...   Bay Area Lyme Foundation , collaborating ... for Tick Borne Illness , Harvard Medical School ... Medicine, University of California, Berkeley, and the Veterans ... finalists of Lyme Innovation , the first ... scientists, clinicians, researchers, entrepreneurs, and investors from several ...
(Date:6/24/2016)... The Academy of Managed Care Pharmacy (AMCP) ... would allow biopharmaceutical companies to more easily share health ... and coverage decisions, a move that addresses the growing ... The recommendations address restrictions in the sharing of ... label, a prohibition that hinders decision makers from accessing ...
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
Breaking Medicine Technology: