Navigation Links
Fat Metabolism Of Heart Muscles Affected By High Blood Pressure

A research conducted by de las Fuentes and colleagues at Washington University School of Medicine in St. Louis have found that hearts with muscle thickening// or hypertrophy due to high blood pressure get less energy because of their reduced fat metabolism. Their finding has been published in the recent issue of the Journal of Nuclear Cardiology.

"The heart is the single most energy-consuming organ per weight in the body," says Lisa de las Fuentes, M.D.

Earlier research led by de las Fuentes' colleague Robert J. Gropler, M.D., showed that heart muscle in people with diabetes is overly dependent on fat for energy. Even though fat is an efficient fuel, burning it for energy creates an unusually high demand for oxygen, making the diabetic heart more sensitive to the drops in oxygen levels that occur with coronary artery blockage.

Gropler is director of the Cardiovascular Imaging Laboratory at the Mallinckrodt Institute of Radiology at the School of Medicine and professor of radiology, medicine and biomedical engineering.

Now this group of Washington University researchers has shown that hearts of non-diabetics with muscle thickening due to high blood pressure have an energy metabolism skewed in the opposite direction -- away from the use of fat for energy.

"Whereas Dr. Gropler found that a high level of fatty acid metabolism could be detrimental, we show that a low level may also be harmful," says de las Fuentes, co-director of the Cardiovascular Imaging and Clinical Research Core Laboratory and assistant professor of medicine. "These findings aren't contradictory. The heart has to be able to choose the energy source, either fats or glucose, most appropriate for its current energy needs and the availability of fuel."

De las Fuentes explains that hearts with muscle thickening, or hypertrophy, get less energy because of their reduced fat metabolism, which leads them to rely more heavily on carbohydrates.< br>
"Carbohydrates produce less energy per molecule than fatty acids," she says. "With hypertrophy, the heart has a higher energy demand because there's more muscle to feed. With less fat metabolism, a greater reliance on carbohydrates may represent a shift to a less-efficient fuel."

The metabolic abnormality can eventually lead to impaired contraction of the heart and to heart failure.

Animal studies by collaborators at Washington University have shown that in mice with thickened heart muscle, genes associated with transporting and breaking down fatty acids are less active than normal -- in other words, the heart's fat-burning machinery is malfunctioning.

In this human study, the researchers studied patients who had high blood pressure that resulted in hypertrophy of the muscle of the left ventricle, the chamber of the heart that pumps blood to the body. The study showed that the greater the muscle mass of the hypertrophic heart, the lower the ability to burn fat. Magnetic resonance scans suggested that hypertrophic heart muscle had subtle abnormalities in contractile function at rest and was less energy efficient.

Normally heart muscle will alter between using fats and carbohydrates as fuel depending on availability. But at times of the day when blood glucose is low -- such as when a person hasn't eaten in a while -- hypertrophic hearts can't switch to burning fatty acids as normal hearts would, possibly leaving them energy deficient, de las Fuentes explains.

"This is the first time these data have been shown in humans," says senior author Victor G. Dávila-Román, M.D., director of the Cardiovascular Imaging and Clinical Research Core Laboratory and professor of medicine, anesthesiology and radiology. "That is particularly significant because hypertension (high blood pressure) is a huge public health problem in the United States. Of the 65 million people with hypertension, between 25 and 50 percent of t hem have some evidence that their heart has been affected by high blood pressure."

Not everyone who has high blood pressure will develop hypertrophy, and not everyone with hypertrophy has long-term problems, according to de las Fuentes. Some people appear to be protected while others appear to be at increased risk, likely due to genetic factors.

"Because we have this evidence that shows that fatty acid metabolism may play a role in this process, we are looking for variations in the metabolism genes in an ongoing clinical study," de las Fuentes says.

Dávila-Román adds that by looking at the genetics of hypertension and hypertensive heart disease, they hope to identify genes that predispose people to both good and bad traits associated with these disorders. Such information promises opportunities for both prevention and treatment of cardiac disease.

Source: Eurekalet
'"/>




Related medicine news :

1. Understanding The Link Between Movement And Metabolism
2. Metabolism cycle of Kala-Azar parasite revealed
3. Adult and Children Have Varied Drug Metabolism
4. Abnormal Glucose Metabolism May Contribute to Chronic Nerve Disorder
5. A New Gene to Contribute in Insulin Metabolism
6. Glucose Sensor That Controls Glucose Metabolism Identified
7. Primitive Yeast Yields Secrets Of Human Cholesterol And Drug Metabolism
8. One in Three Heart Attack Patients Have No Chest Pains
9. Epileptic Seizures Can Be Due to Heart Problem
10. Bypass Heart Surgery Performed Without General Anesthesia
11. New CPR Guidelines issued by Heart Association
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... 2017 , ... Coveros, a leader in agile coaching services ... by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile Transformation ... Agile methodologies in a consistent and high value manner across CMS programs. Coveros ...
(Date:10/12/2017)... ... 12, 2017 , ... CitiDent and San Francisco dentists, Dr. ... Oventus O2Vent technology. As many as 18 million Americans are estimated to suffer ... Oral appliances can offer significant relief to about 75 percent of people with ...
(Date:10/12/2017)... ... 12, 2017 , ... The American College of Medical Informatics (ACMI) will present ... the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... Collen, a pioneer in the field of medical informatics, this prestigious award is presented ...
(Date:10/12/2017)... , ... October 12, 2017 , ... HMP , ... recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ ... on October 11, 2017. , The annual award competition recognizes editorial and design excellence ...
(Date:10/12/2017)... ... October 12, 2017 , ... Health Literacy Innovations (HLI), ... software tool, and the Cancer Patient Education Network (CPEN), an independent professional organization ... a new strategic alliance. , As CPEN’s strategic partner, HLI will help ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017  NDS received FDA 510(k) clearance ... a medical-grade battery-powered display stand specifically designed for endoscopy environments. An ... technology into a clinical solution to support the improvement of patient ... Innovative Design ... Wireless Solution ...
(Date:10/5/2017)... ROSEMONT, Ill. , Oct. 5, 2017 /PRNewswire-USNewswire/ ... American Association of Oral and Maxillofacial Surgeons (AAOMS) ... than opioids – to be used as a ... post-surgical pain. ... relationship, the AAOMS White Paper "Opioid Prescribing: Acute ...
(Date:10/4/2017)... , Oct. 4, 2017 ... single-use, self-contained, illuminating medical devices, today announced regulatory ... Health Surveillance Agency (or Agência Nacional de Vigilância ... first single-use, cordless surgical retractor with integrated LED ... optimal access, illumination and exposure of a tissue ...
Breaking Medicine Technology: