Navigation Links
Fat Cell Protein Hits Type-2 Diabetes

According to researchers a protein found in human fat cells may become key to the development of future treatments for type-2 or adult onset diabetes. According to Dr. Lucino Roseveltte, professor of medicine at 0the Hopkins College of Medicine in New York , there are molecules produced by the fat cells, the adipose tissue//, circulating throughout the body and affecting the functions of different organs. Their research identifies one very significant protein, Acpr30, that is made in fat cells--- and made less abundantly in the fat cells of obese people and animals -- that significantly affects insulin action in the liver.

Type-2 diabetes affects between 2 million and 6 million Americans and is rising in epidemic proportions as obesity rates also rise. Type-2 diabetes accounts for 70 percent to 90 percent of all diabetes cases. The majority of people who have type-2 diabetes are obese, about 60 to 80 percent. According to him the idea has been developed that the adipose cell where the fat is stored is also producing very active molecules that are really functioning as hormones. He said his research team found a very clear mechanism by which an increase or decrease in fat cell size, as happens in obese humans, might cause severe hepatic (liver) insulin resistance because less of a hormone-like protein, Acrp30, is secreted by the fat cell.

The researchers used a genetic approach in cells to generate an exact copy of the Acrp30 protein. They injected mice with Acrp30 until they doubled the protein level. The question was that iIf we simply doubled the concentration of this adipose-derived hormone and then carefully measure the hepatic glucose production -- or action of insulin on the liver-- are we generating a significant effect?' The answer we found was a clear-cut'Yes, according to Roseveltte. What's really interesting about Acrp30 is that we know that it is missing or lower in obese people.

He said the study suggests just small in creases have a major effect in decreasing glucose production in the liver and thereby improving insulin action in the liver. "This significant research points to the liver as the key sight of action by Acpr30," said Dr. Allen Cherrington, professor of physiology at Vanderbilt University Medical School in Nashville. "It could be one key in helping us find new ways to lower glucose profiles in type-2 diabetics and slow the development of disease."

Acrp30 is a very large protein and it can only be given by injection. "The future of this biological discovery is in identifying either the receptor for the protein, in other words how it is working in the liver, and then creating a smaller molecule that will mimic the effect of Acrp30 or perhaps finding a way to stimulate the secretion of Acrp30 within the fat cell," Roseveltte said. "Either of these strategies will be targets of companies trying to develop drugs from this kind of research."


'"/>




Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
3. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
4. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
5. Protein in urine foresees heart disease
6. Levels Of Blood Proteins May Help Heart Disease Care
7. Protein signals need for heart surgery
8. Protein and fat improve memory
9. Clotting Protein plays a role in nerve repair
10. High Levels of Protein Linked to Brain Shrinkage
11. Protein can change worn muscle fibres
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/25/2016)... ... , ... Austin residents seeking Mohs surgery services, can now turn to Dr. ... Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include ... in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn ...
(Date:6/25/2016)... CA (PRWEB) , ... June 25, 2016 , ... As ... with Magna Cum Laude and his M.D from the David Geffen School of Medicine ... and returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Collagen Matrix, ... design, development and manufacturing of collagen and mineral ... announced today that Bill Messer has ... Marketing to further leverage the growing portfolio of ... devices. Bill joins the Collagen Matrix ...
(Date:6/24/2016)... -- The Academy of Managed Care Pharmacy (AMCP) today ... allow biopharmaceutical companies to more easily share health care ... coverage decisions, a move that addresses the growing need ... The recommendations address restrictions in the sharing of product ... a prohibition that hinders decision makers from accessing HCEI ...
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
Breaking Medicine Technology: