Navigation Links
Fat Cell Hormone Could Trigger Diabetes, Heart Disease

African American women could be more prone to diabetes and heart disease because of the presence of Adiponectin, a protein hormone, present in fat cells. //

Researcher Trudy Gaillard, PhD and colleagues today unveiled results of their study that examined the relationships between adiponectin (ADIPO) in the blood and cardiovascular risk factors. ADIPO is known as a hormone that regulates the metabolism of lipids and glucose. It influences how the body responds to insulin and it also has antiinflammatory effects on the cells lining the walls of blood vessels.

While high blood levels of adiponectin have been associated with reduced risk of heart attack and type 2 diabetes, low levels of adiponectin have been found in people who are obese and at increased risk of heart attack. Today’s research now also links lower levels of ADIPO with glucose intolerance and high insulin levels.

“In our study group, we found that ADIPO decreased as glucose tolerance and insulin resistance worsened,” stated Dr. Gaillard. “As subjects progressed from normal glucose tolerance to impaired glucose tolerance to diabetes, we found increases in fasting glucose, insulin, and c-peptide levels, while ADIPO levels decreased”

The research included 53 obese African American women, ranging in age from 38-58 years, mean body mass index at 34.5±5.8, and with varying degrees of glucose tolerance. Oral glucose tolerance test (OGTT) was performed in each subject. Fasting serum glucose, insulin, c-peptide, and lipids and lipoproteins were also obtained. Insulin resistance was measured using homeostasis model assessment.

Levels of ADIPO in the blood decreased as glucose tolerance deteriorated in this group of high-risk African American women. Factors that increase risk of heart disease, high cholesterol, high levels of low density lipoprotein-cholesterol (LDL-C), and triglycerides, increased as glucose tolerance status worsened and ADIPO levels decreas ed. At the same time, HDL-C levels, known as the “good” cholesterol, decreased as glucose tolerance worsened and ADIPO levels decreased.

Trudy Gaillard, PhD, program director, Prevention of Diabetes in African Americans Program, conducted this research with colleagues Dara Shuster, MD, and Kwame Osei, MD from the Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, Ohio.

Additional conference information and news from the conference can be found at


Related medicine news :

1. Levothyroxine Thyroid Hormone Replacement, Approved for Hypothyroidism
2. Hormone replacement Therapy a headache
3. Ovarian cancer in relationship with Hormone therapy
4. Hormone contraceptives lead to bone problems
5. Hormone treatment helps obese people slim down
6. Hormone Deficiency Results In Miscarriage
7. Hormones Linked To Migraines
8. Hormone replacement therapy helps women
9. Decrease of Hunger Hormone after Obesity Surgery
10. Possible benefits of Hormone Replacement Therapy
11. Hormone replacement therapy improves sexual function
Post Your Comments:

(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... ... for Tuberous Sclerosis Complex (TSC), as well as raising public awareness of the ... they need it—presented a third donation of $35,000 to bolster progress at the ...
(Date:11/25/2015)... ... 25, 2015 , ... Bunion Bootie , the newest ... of the early holiday shopping season. Starting Wednesday November 25th, Bunion Booties are ... Friday promotional pricing is in addition to any automatic discounts applied when buying ...
(Date:11/24/2015)... ... ... Dr. Todd S. Afferica, a noted general dentist in Norcross, GA ... Afferica now uses the BIOLASE WaterLase iPlus 2.0™ in many of his dental procedures. ... traditional cutting tools, such as the scalpel and high-speed drill, which can both cause ...
(Date:11/24/2015)... ... , ... Charitable giving is at its peak during the holidays. In ... of the year totalling over $358 billion in 2014. With more than 1.5 ... those individuals who want to “give back” during the holidays. , “With so many ...
(Date:11/24/2015)... (PRWEB) , ... November 25, 2015 , ... ... technologies and development solutions for drugs, biologics, consumer health and global clinical supply ... present at the upcoming Clinical Trial Supply East Asia Conference, to be held ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... -- Teledyne DALSA , a Teledyne Technologies company and ... its CMOS X-Ray detector for mammography at the ... 3, at McCormick Place in Chicago . ... imaging will be on display in the South Hall, Booth ... X-Ray detectors is the industry benchmark for high speed imaging ...
(Date:11/24/2015)... , Nov. 24, 2015  Boston Scientific Corporation (NYSE: ... Oppenheimer 26th Annual Healthcare Conference on December 8, in ... Susie Lisa , vice president, Investor Relations, will participate ... beginning at approximately 8:35 a.m. ET. --> ... in a 30-minute question-and-answer session with the host analyst ...
(Date:11/24/2015)... 2015   Renowned ... deliver s advice and insights on supplements ... More than 50% of Dubai ... to the DHA   femMED launches comprehensive solutions for women ... Dubai residents are not consuming enough to keep themselves ...
Breaking Medicine Technology: