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Extra Cortisol Protects Women’s Mood Under Stres

, 15 and 45 minutes participants arrived at the lab, and 1, 45, and 60 minutes after the stress test. Afterwards, the cortisol-treated women developed, on average, less negative mood states as a result of the stress-producing activity when compared with placebo-treated women. The high dose of cortisol seems to have worked as a buffer.

Wolf says that whereas chronically elevated cortisol levels can be damaging to both mood and immunity, a short spike in cortisol levels may be protective. He comments, “The difference between acute cortisol elevations and chronic cortisol hyperactivity appears to be important.”

Prior research has suggested that low-dose treatment with cortisol can offer relief from the core symptoms of post-traumatic stress disorder. In addition, in patients with social phobia exposed to a social stress situation, pre-treatment with cortisol has reduced anxiety. This new study in healthy participants adds to the growing body of evidence that cortisol may be a useful clinical tool. Says Wolf, “Our study suggests that when it comes to the negative effects of stress on the emotions, an anticipatory rise in cortisol levels prior to a stressor might help someone to cope with the stressor more efficiently. This might have implications for treating and preventing post-traumatic stress and other anxiety disorders.”

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