Navigation Links
Extent of Brain Involvement at Diagnosis May Predict Brain Atrophy

In patients with recently diagnosed multiple sclerosis, the extent of accumulated brain tissue loss and overall// lesion load as determined by magnetic resonance imaging (MRI) may predict the rate of cerebral atrophy.

MRI provides valuable information about the progression of multiple sclerosis (MS), according to background information in the article. MRI is used to monitor the number and volume of MS-related lesions (damaged tissue), which can help monitor the evolution of the disease but does not appear to be associated with the patient’s disability status. Brain volume, also measured by MRI, “is currently considered to be a marker of the neurodegenerative component of MS pathological features, thereby better reflecting the pathological background of irreversible clinical disability in MS,” the authors write.

Bas Jasperse, M.D., and colleagues at the VU University Medical Center, Amsterdam, the Netherlands, performed brain MRI shortly after diagnosis and again after two years in 89 patients with MS (average age, 37.5). The numbers and volume of two types of lesions apparent on MRI, black hole (dark appearing lesions that indicate the loss of myelin, neurons’ protective coating) and T2 (newer, brighter appearing lesions), were recorded along with brain volume. Change in brain volume between scans was calculated, and participants were also assessed for neurologic disability.

“The mean [average] annualized rate of cerebral atrophy was -0.9 percentage of brain volume change per year,” the authors write. “Baseline normalized brain volume and baseline T2 lesion load were identified as explanatory variables for the subsequent percentage of brain volume change per year and yielded a regression model that explained 31.2 percent of the variance in percentage of brain volume change per year.”

In other words, “patients who have acquired more brain tissue loss and more T2 lesions are prone to have a higher rate of subsequent brai n atrophy,” the authors conclude. “In this relationship, the extent of brain tissue loss seemed more important than lesional activity. Because a higher rate of cerebral atrophy is predictive of worse clinical functioning at a later stage in the MS disease course, our findings suggest that these two baseline variables could have prognostic value for clinical functioning in early MS.”

Source-Newsise
SRM
'"/>




Related medicine news :

1. New Findings Could Reduce The Extent Of Spinal Cord Injuries
2. Use of Cellular Phones associated with Increased risk of Brain Tumors
3. Brain death – How to cope with it
4. “Brain fingerprinting”- The new lie detectr
5. Nasal Spray Could Take Drugs Direct to Brain.
6. Virus Combats Brain Tumour
7. Nasal Spray Could Take Drugs Directly to Brain
8. Control of anger disorder connected to Brain Dysfunction
9. High Levels of Protein Linked to Brain Shrinkage
10. Brain damage affects artistic skill
11. Brain cells protected by new compounds
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... ... December 07, 2016 , ... When it came time to blow out his candles on ... later, the Pediatric Heart Transplant team at Joe DiMaggio Children’s Hospital surprised his ... the hospital’s 30th heart transplant recipient. , “He was playing at home, when we ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... financial consultation services to residents in the Sacramento/Folsom region, is initiating a charity ... facility. , The Another Choice Another Chance treatment center in Sacramento works to ...
(Date:12/7/2016)... , ... December 07, 2016 , ... AlignLife clinics nationwide ... Many children are not fortunate enough to receive bountiful gifts wrapped tightly under a ... can bring to the children of the world. , In exchange for generous donations, ...
(Date:12/7/2016)... OR (PRWEB) , ... December 07, 2016 , ... Sharon ... Water, Global Climate Change and Your Health on Voice of America, declared on her ... to call attention to the fact that when these bullies attack leaders in corporate ...
(Date:12/7/2016)... ... December 07, 2016 , ... Delete® - Tattoo Removal and Laser Salon Offers ... Season. Save Up To 33% Off Botox® and Juvederm® Products Now Through December 31, ... with Delightful Deals on Botox® and Juvederm® just in time for the ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... Research and Markets has announced the addition of the ... to 2021" report to their offering. ... , , The immunohistochemistry (IHC) ... a CAGR of 7.3% during the forecast period of 2016 to 2021. ... rapidly increasing geriatric population across the globe are the primary driving the ...
(Date:12/7/2016)... 7, 2016  Palatin Technologies, Inc. ("Palatin") (NYSE ... a previously disclosed underwritten public offering of units ... as sole book-running manager, Roth Capital Partners acted ... as co-manager for the offering. "This ... net proceeds, allowing us to continue advancing bremelanotide ...
(Date:12/7/2016)... , Dec. 7, 2016 DelveInsight,s, ... report provides in depth insights on the ... the Janus Kinase 3 (JAK3) Inhibitors. The ... various stages of development including Discovery, Pre-clinical, ... and Preregistration. Report covers the product clinical ...
Breaking Medicine Technology: