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Exposure To Dioxins Affects Male Reproductive System

A new study by Researchers at UT Southwestern Medical Center indicates that exposure to TCDD, the most toxic dioxin toxin contained in the Agent Orange may influence// the male endocrine and reproductive systems in several ways, resulting in the limited growth of prostate gland or lowering testosterone levels.

The cohort study involved more than 2000 Air Force veterans who served during the Vietnam War and was published in the November issue of the journal Environmental Health Perspectives.

"Until now, we did not have very good evidence whether or not dioxins affect the human reproductive system," said Dr. Amit Gupta, an urologist at UT Southwestern and the study's lead author. "Now we know that there is a link between dioxins and the human prostate leading us to speculate that dioxins might be decreasing the growth of the prostate in humans like they do in animals."

The researchers found that veterans exposed to dioxin had lower incidence rates of benign prostate hyperplasia (BPH), better known as enlarged-prostate disease. BPH is a disease in humans that is caused by an enlargement of the prostate. Patients must strain to pass urine and they also must urinate frequently. BPH can lead to complications such as an inability to urinate and urinary tract infection. Surgery is sometimes needed.

Dr. Claus Roehrborn, professor and chairman of urology at UT Southwestern and a study author, said, "We know that dioxin causes many endocrine disturbances in the human body. The study indirectly proves that BPH is an endocrine disorder."

Regarding the decreased risk for BPH found in the veterans groups, Dr. Gupta cautioned that the finding should not be interpreted as a positive result.

"It may be construed that a decrease in the risk of BPH is not a harmful effect, but the larger picture is that dioxins are affecting the normal growth and development of the reproductive system. Moreover, several effective treatments a
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