Navigation Links
Experts Propose New Criteria for Alzheimer's Diagnosis

An international group of experts have proposed new criteria for the diagnosis of Alzheimer's disease (AD), as they feel that the existing criteria are out of date due to unprecedented growth of scientific knowledge in the field.

"(These existing criteria) are the prevailing diagnostic standards in research; however, they have now fallen behind the unprecedented growth of scientific knowledge. Distinctive and reliable biomarkers of AD are now available through structural MRI, molecular neuroimaging with PET, and cerebrospinal fluid analyses," says Dr. Bruno Dubois, Salpetriere Hosptial, Paris, France.

According to experts, the new criteria for probable AD requires that patients show progressive memory loss over more than six months, and at least one or more of the supportive biomarker criteria-like atrophy in a particular part of the brain shown by MRI, abnormal biomarker proteins in the cerebrospinal fluid, a specific pattern on PET of the brain, and a genetic mutation for AD within the immediate family.

"These new criteria are centred on a clinical core of early and significant episodic memory impairment...the timeliness of these criteria is highlighted by the many drugs in development that are directed at changing pathogenesis," say the authors, whose proposal is put forward in a Position Paper published in The Lancet Neurology.

The researchers, however, admit that validation studies are required to advance the new criteria and optimise their sensitivity, specificity and accuracy.

"When effective disease-modifying medications are available, the argument for such biologically based studies will be even more compelling," conclude the authors.

"These proposed criteria move away from the traditional two-step approach of first identifying dementia according to degree of functional disability, and then specifying its cause. Rather, they aim to define the clinical, biochemical, struct ural, and metabolic presence of AD," they say.

Dr Norman Foster, Center for Alzheimer's Care, Department of Neurology, University of Utah, US, feels that it is time that advanced technologies be involved in the diagnosis of AD.

"We should seize this opportunity to reopen the discussion of Alzheimer's disease diagnosis. The time is right to use the advanced technology at our disposal to improve the early, accurate diagnosis of dementia and develop more effective treatments," says the researcher.

AD is a neurodegenerative disease characterised by progressive cognitive deterioration, together with declining activities of daily living and by neuropsychiatric symptoms or behavioural changes. It is the most common form of dementia.

The existing criteria were published in 1984 by the National Institute of Neurological Disorders and Stroke-Alzheimer Disease and Related Disorders (NINCDS-ADRDA) working group.


'"/>




Related medicine news :

1. Good carb, bad carb? Experts debate.
2. Spread Of Rocky Mountain Spotted Fever Is A Probability, Say Experts
3. Experts Recommend Preventive Measures For Avian Flu To Begin From Farms
4. Experts Insist That Neonatal Herpes Be Reported Regularly
5. Experts State Strategies To Increase Good Cholesterol
6. Cancer Can Recur Any Time, Experts Caution
7. Experts Building Bird Flu Warning System
8. Human Growth Hormone (HGH) - View of Experts
9. Experts urging artery screening in the UK
10. Genetic Experts of Hopkins Assists In Identifying Hurricane Katrina Victims
11. Birds Being Shot Owing To Bird Flu Fear: Wildlife Experts
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2016)... ... May 26, 2016 , ... Dr. ... Foundation Fighting Blindness, Long Island Chapter on June 4, 2016, 1:30-3:30 pm at ... Maisel, founder of Retina Group of New York , is a Board ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... comprehensive treatment for eating disorders, is opening a brand new child and adolescent ... ages 8-17 and their families with even more specialized eating disorder treatment and ...
(Date:5/26/2016)... ... May 26, 2016 , ... The MIAMI Institute for Age Management and ... Adonis Maiquez MD, ABAARM. Dr. Adonis , Wellness Physician of the MIAMI Institute ... of the Institute for Functional Medicine. , He also heads up FITTLab, the comprehensive ...
(Date:5/26/2016)... ... ... On May 23rd during the National Eye Institute’s “Healthy Vision Month”, Sharon ... honored by Ashram, Inc. as the world’s foremost water visionary. , “Sharon Kleyne is ... the Nile to fill their red clay pots with life-sustaining water.” Said Ashram co-founder ...
(Date:5/26/2016)... ... 2016 , ... Saint Francis Hospital & Medical Center has ... have paid off. Since implementation of these efforts, surgical errors and readmissions ... patient experiences and reduce costly complications. Since implementation in 2011, safety efforts have: ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... GERMANTOWN, Maryland , May 25, 2016 /PRNewswire/ ... Frankfurt Prime Standard: QIA) today announced that the company has ... GmbH to develop and commercialize predictive assays in oncology. An ... a marker to predict effectiveness of anthracycline treatment in triple ... are pleased to partner with Therawis, which developed the PITX2 ...
(Date:5/25/2016)... YORK , May 25, 2016 ... Market Size, Share, Development, Growth and Demand Forecast to ... Syringe, Insulin Pump and Others)" published by P&S Market ... at $9,998.3 million in 2015, and it is expected ... Based on type, the insulin pump segment is expected ...
(Date:5/25/2016)... 2016 Digital Health Dialog, LLC dba ... the US Patent and Trademark Office of U.S. ... processes for electronic opt-­in and processing of discount ... HIPAA compliance and otherwise. Logo - ... "Our technology allows for individuals to opt­-in ...
Breaking Medicine Technology: