Navigation Links
Experts Propose New Criteria for Alzheimer's Diagnosis

An international group of experts have proposed new criteria for the diagnosis of Alzheimer's disease (AD), as they feel that the existing criteria are out of date due to unprecedented growth of scientific knowledge in the field.

"(These existing criteria) are the prevailing diagnostic standards in research; however, they have now fallen behind the unprecedented growth of scientific knowledge. Distinctive and reliable biomarkers of AD are now available through structural MRI, molecular neuroimaging with PET, and cerebrospinal fluid analyses," says Dr. Bruno Dubois, Salpetriere Hosptial, Paris, France.

According to experts, the new criteria for probable AD requires that patients show progressive memory loss over more than six months, and at least one or more of the supportive biomarker criteria-like atrophy in a particular part of the brain shown by MRI, abnormal biomarker proteins in the cerebrospinal fluid, a specific pattern on PET of the brain, and a genetic mutation for AD within the immediate family.

"These new criteria are centred on a clinical core of early and significant episodic memory impairment...the timeliness of these criteria is highlighted by the many drugs in development that are directed at changing pathogenesis," say the authors, whose proposal is put forward in a Position Paper published in The Lancet Neurology.

The researchers, however, admit that validation studies are required to advance the new criteria and optimise their sensitivity, specificity and accuracy.

"When effective disease-modifying medications are available, the argument for such biologically based studies will be even more compelling," conclude the authors.

"These proposed criteria move away from the traditional two-step approach of first identifying dementia according to degree of functional disability, and then specifying its cause. Rather, they aim to define the clinical, biochemical, struct ural, and metabolic presence of AD," they say.

Dr Norman Foster, Center for Alzheimer's Care, Department of Neurology, University of Utah, US, feels that it is time that advanced technologies be involved in the diagnosis of AD.

"We should seize this opportunity to reopen the discussion of Alzheimer's disease diagnosis. The time is right to use the advanced technology at our disposal to improve the early, accurate diagnosis of dementia and develop more effective treatments," says the researcher.

AD is a neurodegenerative disease characterised by progressive cognitive deterioration, together with declining activities of daily living and by neuropsychiatric symptoms or behavioural changes. It is the most common form of dementia.

The existing criteria were published in 1984 by the National Institute of Neurological Disorders and Stroke-Alzheimer Disease and Related Disorders (NINCDS-ADRDA) working group.


'"/>




Related medicine news :

1. Good carb, bad carb? Experts debate.
2. Spread Of Rocky Mountain Spotted Fever Is A Probability, Say Experts
3. Experts Recommend Preventive Measures For Avian Flu To Begin From Farms
4. Experts Insist That Neonatal Herpes Be Reported Regularly
5. Experts State Strategies To Increase Good Cholesterol
6. Cancer Can Recur Any Time, Experts Caution
7. Experts Building Bird Flu Warning System
8. Human Growth Hormone (HGH) - View of Experts
9. Experts urging artery screening in the UK
10. Genetic Experts of Hopkins Assists In Identifying Hurricane Katrina Victims
11. Birds Being Shot Owing To Bird Flu Fear: Wildlife Experts
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/25/2016)... ... , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department ... in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at ... Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 ...
(Date:6/24/2016)... Los Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... plastic surgery procedures that most people are unfamiliar with. The article goes on to ... known procedures, but also many of these less common operations such as calf and ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016  In a startling report released today, National Safety ... lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... how states are tackling the worst drug crisis in recorded U.S. ... Kentucky , New Mexico , ... Of the 28 failing states, three – Michigan ...
(Date:6/23/2016)... 2016 Capricor Therapeutics, Inc. ... biotechnology company focused on the discovery, development and ... enrollment in its ongoing randomized HOPE-Duchenne clinical trial ... of its 24-patient target. Capricor expects the trial ... of 2016, and to report top line data ...
(Date:6/23/2016)... , June 23, 2016 , ... on Thursday, July 7, 2016 , , , , LOCATION: ... , , , , EXPERT PANELISTS:  , , , ... Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and ... The global pharmaceutical industry is witnessing an exceptional era. ...
Breaking Medicine Technology: