Navigation Links
Experts Propose New Criteria for Alzheimer's Diagnosis

An international group of experts have proposed new criteria for the diagnosis of Alzheimer's disease (AD), as they feel that the existing criteria are out of date due to unprecedented growth of scientific knowledge in the field.

"(These existing criteria) are the prevailing diagnostic standards in research; however, they have now fallen behind the unprecedented growth of scientific knowledge. Distinctive and reliable biomarkers of AD are now available through structural MRI, molecular neuroimaging with PET, and cerebrospinal fluid analyses," says Dr. Bruno Dubois, Salpetriere Hosptial, Paris, France.

According to experts, the new criteria for probable AD requires that patients show progressive memory loss over more than six months, and at least one or more of the supportive biomarker criteria-like atrophy in a particular part of the brain shown by MRI, abnormal biomarker proteins in the cerebrospinal fluid, a specific pattern on PET of the brain, and a genetic mutation for AD within the immediate family.

"These new criteria are centred on a clinical core of early and significant episodic memory impairment...the timeliness of these criteria is highlighted by the many drugs in development that are directed at changing pathogenesis," say the authors, whose proposal is put forward in a Position Paper published in The Lancet Neurology.

The researchers, however, admit that validation studies are required to advance the new criteria and optimise their sensitivity, specificity and accuracy.

"When effective disease-modifying medications are available, the argument for such biologically based studies will be even more compelling," conclude the authors.

"These proposed criteria move away from the traditional two-step approach of first identifying dementia according to degree of functional disability, and then specifying its cause. Rather, they aim to define the clinical, biochemical, struct ural, and metabolic presence of AD," they say.

Dr Norman Foster, Center for Alzheimer's Care, Department of Neurology, University of Utah, US, feels that it is time that advanced technologies be involved in the diagnosis of AD.

"We should seize this opportunity to reopen the discussion of Alzheimer's disease diagnosis. The time is right to use the advanced technology at our disposal to improve the early, accurate diagnosis of dementia and develop more effective treatments," says the researcher.

AD is a neurodegenerative disease characterised by progressive cognitive deterioration, together with declining activities of daily living and by neuropsychiatric symptoms or behavioural changes. It is the most common form of dementia.

The existing criteria were published in 1984 by the National Institute of Neurological Disorders and Stroke-Alzheimer Disease and Related Disorders (NINCDS-ADRDA) working group.


'"/>




Related medicine news :

1. Good carb, bad carb? Experts debate.
2. Spread Of Rocky Mountain Spotted Fever Is A Probability, Say Experts
3. Experts Recommend Preventive Measures For Avian Flu To Begin From Farms
4. Experts Insist That Neonatal Herpes Be Reported Regularly
5. Experts State Strategies To Increase Good Cholesterol
6. Cancer Can Recur Any Time, Experts Caution
7. Experts Building Bird Flu Warning System
8. Human Growth Hormone (HGH) - View of Experts
9. Experts urging artery screening in the UK
10. Genetic Experts of Hopkins Assists In Identifying Hurricane Katrina Victims
11. Birds Being Shot Owing To Bird Flu Fear: Wildlife Experts
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2017)... Salt Lake City, UT (PRWEB) , ... April 28, 2017 , ... ... that exist in some of their formulas. This begins with the popular ClearLungs Extra ... impacted, they will be changing the formula in the following ways:, ...
(Date:4/28/2017)... (PRWEB) , ... April 28, 2017 , ... ... http://www.foodsthathealdaily.com , http://www.wiredlifesolutions.com , “Computers are everywhere and they’re here to ... of Water, Global Climate Change and Your Health on Voice America sponsored by ...
(Date:4/28/2017)... ... April 28, 2017 , ... Children and ... more adverse experiences than children in the general population. That’s because foster care ... or other family challenges. While no fault of their own, youth who have ...
(Date:4/28/2017)... ... , ... People are starting to accept that hearing aids can be helpful ... stigma it had when great-grandpa wore his hearing aids years ago,” said Dr. Maura ... North American Speaker Series (NASS) segment. “He probably wore an iPod-size hearing aid ...
(Date:4/28/2017)... ... April 28, 2017 , ... Phytomer ... East region. Côté has 20+ years of experience within the beauty industry, ranging ... with an array of high-end cosmetic brands, retail brands and outlets in Canada ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... LONDON , April 19, 2017 ... to stimulate an immune response in pets such ... vaccine products are of various types such as ... Vaccines, Toxoid Vaccines, DNA Vaccines and Recombinant Vaccines. ... such as virus or bacteria, which have been ...
(Date:4/18/2017)... Ohio , April 18, 2017  Cardinal Health ... Non-GAAP 1 fiscal 2017 earnings per share (EPS) ... and 2019.  This is in conjunction with this morning,s ... Deep Vein Thrombosis and Nutritional Insufficiency businesses. ... from continuing operations will be at the bottom of ...
(Date:4/18/2017)... -- Astute Medical, Inc., developer of biomarkers for better healthcare, ... the 2017 National Kidney Foundation (NKF) Spring Clinical ... 22. Physicians will present data on two biomarkers, ... acute kidney injury (AKI) during the management of patients ... Elevated levels of TIMP-2 and IGFBP-7 have been shown ...
Breaking Medicine Technology: