Navigation Links
Experimental Drug Ketasyn(TM) (AC-1202) Treats Alzheimer's as Diabetes of the Brain

Accera, Inc. announced today that recent data from its Phase IIb study in Alzheimer's disease (AD) support findings showing that AD may effectively be thought of and treated as diabetes of the brain.

AD is widely believed to be caused by the accumulation of amyloid beta plaques in the brain, yet recent research from Brown University has shown that inducing insulin resistance in the brains of mice gives rise to some of the behavioral and pathological symptoms of AD. AD may therefore be thought of as brain-specific "type 3 diabetes," an idea that is further supported by brain images of AD patients showing decreased glucose metabolism.

All cells in the body require glucose, which is controlled with the aid of the hormone insulin. In type 2 diabetes, which accounts for 90% of the 180 million diabetes cases worldwide according to the World Health Organization, certain cells become resistant to insulin and therefore cannot take in enough glucose. When brain cells become insulin-resistant, as happens in AD, inadequate glucose leads to damage that results in impaired memory and cognition and brain shrinkage.

Because these metabolic defects in the brain often appear 10 to 20 years earlier than other AD symptoms, targeting them may allow for earlier treatment of the disease. Based on this hypothesis, Accera is developing the AD drug, Ketasyn(TM) (AC-1202), which provides glucose-deprived brain cells with an alternative energy source. Ketasyn is converted by the liver into ketone bodies, which brain cells can use for energy even when their ability to metabolize glucose is impaired.

Dr. Samuel Henderson, Executive Director of Research at Accera, said, "While many drugs currently under development for AD target production and clearance of amyloid beta plaques, our approach is to address a much earlier event. Declines in glucose use are visible decades before there is extensive amyloid deposition and decades before clinical
'"/>




Page: 1 2

Related medicine news :

1. Experimental treatment for Ebola Virus Shows promising results in mice
2. Experimental drug to fight flu
3. Experimental SARS Vaccine
4. Experimental vaccine for shingles is effective
5. Experimental Blood Test May Spot Heart Attack Risk, Study Says
6. Five AIDS Patients To Receive Experimental Anti-retroviral Drugs
7. Protection against HIV and Herpes is possible with the Experimental Microbicide
8. Experimental Therapy Effective Against Malignant Melanoma in Horses
9. Experimental Alzheimer’s Drug curbs the disease in mic
10. New Guidelines to Be Laid While Testing Experimental Drugs
11. Experimental Drug Deals Effectively with Prostate Cancer Cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Experimental Drug Ketasyn Treats Alzheimer Diabetes the Brain

(Date:3/28/2015)... 2015 India Network visitor health ... available to all visitors who purchase the plan before ... are encouraged to purchase the insurance program as soon ... proper coverage for pre-existing medical conditions. Parents and grandparents ... medical conditions with serious consequences to their health. Many ...
(Date:3/28/2015)... (PRWEB) March 28, 2015 One in ... according to research presented today at the American Orthopaedic ... The study examined the long term success of surgery ... “We examined survey data from 242 patients who underwent ... Justin P. Roe, MBBS, FRACS, from North Sydney Orthopaedic ...
(Date:3/28/2015)... Genomic medicine experts have sequenced the ... the first time, key information for understanding and treating ... newly posted story on the Surviving Mesothelioma website. ... Columbia, the British Columbia Cancer Agency, and PhenoPath lab ... molecular alterations and mutations that can lead to ...
(Date:3/28/2015)... 28, 2015 Healthpointe’s otolaryngologists, medical practitioners ... throat disorders, are now offering a wide variety ... which is characterized by the presence of phantom sounds ... people, tinnitus is a prevalent symptom that can arise ... is non-fatal, tinnitus can impede a person’s quality of ...
(Date:3/28/2015)... NY (PRWEB) March 28, 2015 ... of dietary supplements announces the release of their ... was shown in two randomized, double-blind, placebo-controlled clinical ... and waist and hip size. MuffinStop™ is a ... indicus and Garcinia mangostana, fused together to create ...
Breaking Medicine News(10 mins):Health News:India Network Health Insurance Today Announces New Eligibility Criteria for Pre-existing Condition Health Insurance Coverage for Visitors to the United States 2Health News:India Network Health Insurance Today Announces New Eligibility Criteria for Pre-existing Condition Health Insurance Coverage for Visitors to the United States 3Health News:Young Athletes at Greater Risk for Re-Injury after ACL Surgery 2Health News:New Genomics Research May Help Doctors Tailor Mesothelioma Treatment, According to Surviving Mesothelioma 2Health News:Healthpointe now Offering Tinnitus Treatments in Clinics throughout Southern California 2Health News:Purity Products Releases Revolutionary New Weight Loss Product, MuffinStop™ 2
... reproductive success of both men and women is influenced by ... of Sheffield. The study, which was published yesterday (7 ... of Sciences , found that women with higher levels of ... to a larger number of children in societies with traditionally ...
... are immune to a stroke. You may feel healthy; you may ... more vulnerable than you know. That could be because of the ... a result of research from Hopital Notre Dame in Montreal, two ... so silent any more. Lead investigator, neurologist Dr. Alexandre ...
... Researchers from the BC Centre for Excellence in ... released a comprehensive study revealing that the 2008 IAS-USA ... benefits for individuals infected with HIV and society as ... in the research journal PLoS ONE , shows ...
... HACKENSACK, N.J. (June 07, 2010)The John Theurer Cancer Center ... Division of Radiation Oncology has recognized Joseph Hanley, Ph.D., ... his team for outstanding excellence in patient safety. ... exceptional work developing and maintaining Intensity-Modulated Radiation Therapy (IMRT) ...
... very different organisms, they share a surprising number of biological ... one of these mechanisms may be the answer for turning ... of the Molecular Biology and Ecology of Plants Department at ... on cell growth in plants. Now, in a laboratory setting, ...
... most immediate goal for caregivers is to get appropriate ... stop the seizing activity. In a paper published ... emergency medicine assistant professor Jason McMullan, MD, found that ... be with the least direct medication. In the ...
Cached Medicine News:Health News:Research shows personality can predict fertility 2Health News:Under 50? Silent duo could put you at risk for a big stroke 2Health News:Under 50? Silent duo could put you at risk for a big stroke 3Health News:Updated HIV therapy guidelines would reduce risk of transmission, save lives, billions in costs 2Health News:Updated HIV therapy guidelines would reduce risk of transmission, save lives, billions in costs 3Health News:The John Theurer Cancer Center recognizes medical physics team for safety track record 2Health News:A turn-off for cancer 2Health News:Non-IV-administered medication just as effective in stopping seizures 2
(Date:3/27/2015)...  Victoria Vein & Surgery Clinic is the only clinic ... in Victoria, Texas . The clinic specializes ... laser treatments for a variety of medical and cosmetic conditions. ... more services for their patients. Since adding laser tattoo removal, ... residents get rid of their unwanted ink. ...
(Date:3/27/2015)... , March 27, 2015   Cypher ... today announced new data showing that, compared to ... technology provided highly equivalent interpretations of whether ... and did so in a fraction of the ... way for more comprehensive genetic analysis in non-invasive ...
(Date:3/27/2015)... Inc. (NYSE and SIX: ZMH) is celebrating a key milestone in 2015 ... System. ,   ... the NexGen knee system, with its innovative design and component ... the NexGen knee have taken place worldwide. ... importance of design innovation and component quality for surgeons and patients alike," ...
Breaking Medicine Technology:Victoria Vein And Surgery Clinic Uses Advanced Astanza Duality Tattoo Removal Technology 2New Data at ACMG Shows Cypher's Software Can Automate Interpretation of Genetic Variants to Advance Non-invasive Prenatal Testing 2New Data at ACMG Shows Cypher's Software Can Automate Interpretation of Genetic Variants to Advance Non-invasive Prenatal Testing 3Zimmer Celebrates Key Milestones For NexGen Complete Knee System 2
... ACCESS PHARMACEUTICALS, INC. (OTC Bulletin ... commercial launch of MuGard, an FDA approved treatment for oral ... Access intends to commercially launch MuGard in North America ... pertaining to the launch include: , Manufacturing : ...
... Nov. 11 Pharma market research thought leaders are discovering ... opportunities in the pharmaceutical industry. The last twelve months ... Pharmaceutical market research is no exception. But those ... information today will certainly rise to be the new leaders ...
Cached Medicine Technology:Access Pharmaceuticals Provides Update on MuGard Commercial Launch in North America 2Access Pharmaceuticals Provides Update on MuGard Commercial Launch in North America 3Access Pharmaceuticals Provides Update on MuGard Commercial Launch in North America 4Executives Reveal Secrets to Capitalize on New Developments in Pharmaceutical Marketing Research 2
The Surgiflex WAVE XP couples the state-of-the-art Surgiflex WAVE Probe with the convenience of a truly portable battery-powered pump....
... is a minimally invasive, highly effective surgical ... incontinence. GYNECARE TVT is positioned close to ... and when needed, TVT provides tension-free support ... The procedure takes approximately 20 to 30 ...
...
...
Medicine Products: