Navigation Links
Experimental Drug Causes Cytokine Storm

A clinical trail with an experimental drug designed to treat chronic inflammatory conditions and leukemia resulted in an immune system overreaction leading// to six British men involved in the trail becoming seriously ill. All the six men have since recovered from the drug reaction.

Dr. Ganesh Suntharalingam and colleagues at Northwick Park Hospital in northwest London said the immune system overreaction, known as a cytokine storm, was an unforeseeable consequence of taking the drug.

In the New England Journal of Medicine, the doctors have noted that their case will help understand what happens when immune system overreacts, which might well again happen in future clinical trails.

Six of the eight men involved in the trail became ill shortly after they were given infusions of TGN1412, a drug engineered to affect immune system cells known as CD28 cells.

The drug made by made by German biotechnology firm TeGenero AG were given to six men who were paid volunteers in a study being run by U.S. drug research company Parexel International Corp on behalf of TeGenero.

While two of the men involved in the trial got a dummy infusion, six others who got the drug reported headaches, shivers, nausea, diarrhea and lower back pain within 90 minutes of taking the drug.

One of the patients involved in the trail became so ill that he had to be put on the ventilator following which the doctors decided to put the others also into intensive care. This was followed by a dramatic two weeks during which the previously healthy men developed difficulty in breathing and had symptoms that looked like a serious sepsis infection.

Initially, the doctors struggled to keep the men going as they tried to figure out what had gone wrong until the blood test showed that they had a cytokine storm. Such over-response of the immune system has been described in patients with avian influenza. It took two weeks for the pat ients to stabilize and recover.

"Regulatory authorities, who tested TGN1412 from the same batch as the infused drug, found no errors in its manufacture, formulation, or administration and found no contamination," the researchers added.


'"/>




Related medicine news :

1. Experimental treatment for Ebola Virus Shows promising results in mice
2. Experimental drug to fight flu
3. Experimental SARS Vaccine
4. Experimental vaccine for shingles is effective
5. Experimental Blood Test May Spot Heart Attack Risk, Study Says
6. Five AIDS Patients To Receive Experimental Anti-retroviral Drugs
7. Protection against HIV and Herpes is possible with the Experimental Microbicide
8. Experimental Therapy Effective Against Malignant Melanoma in Horses
9. Experimental Alzheimer’s Drug curbs the disease in mic
10. New Guidelines to Be Laid While Testing Experimental Drugs
11. Experimental Drug Deals Effectively with Prostate Cancer Cells
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... ... March 28, 2017 , ... Columbus OH. Dr. Justin ... one of few medical professionals in the country to sit on the 2017 National ... Aesthetics, in just 2 years Dr. Harper helped propel the clinic from a small ...
(Date:3/28/2017)... Los Angeles, CA (PRWEB) , ... March 28, ... ... Pediatrics credential, which will be offered by the American Association of Integrative Medicine ... Saturday presentations for healthcare providers at the AutismOne 2017 Conference in Colorado Springs. ...
(Date:3/28/2017)... ... , ... Public relations pros work hard to earn placements and build ... many results are clear, much of PR is hard to quantify. Goal-setting and measurement ... measurement, firms should always take an all-inclusive approach that takes both traditional and non-traditional ...
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... With expansion ... Marshallville, Georgia, in early March. , The seed processing plant opened in Marshallville in ... since 2016. The new office allows opportunity for transition of Patten Seed operations to ...
(Date:3/28/2017)... Albertson, NY (PRWEB) , ... March 28, 2017 , ... Oily skin is a common ... with Advanced Dermatology has a lot to offer to the discussion of dealing ... good news is that there are many home remedies that can help remove the oily ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... 2017 "Chemotherapy Induced Neutropenia (CIN) – Market Insights, Epidemiology ... global market trends of the Chemotherapy Induced Neutropenia for the seven ... Europe ( France , Germany ... , UK) and Japan , as well as ... the world (RoW). The Report covers the therapeutics market ...
(Date:3/28/2017)... 28, 2017  Rosen Law Firm, a global investor ... action lawsuit on behalf of purchasers of Kitov Pharmaceutical ... and/or traceable to Kitov,s initial public offering on or ... open market from November 20, 2015 through February 3, ... seeks to recover damages for Kitov investors under the ...
(Date:3/28/2017)... March 28, 2017  Orexigen Therapeutics, Inc. (Nasdaq: ... for the fourth quarter and year ended December 31, ... of transformational progress for Orexigen, beginning with the re-acquisition ... Commencing early March, the team at Orexigen demonstrated remarkable ... which reshaped and strengthened our Company while rewarding us ...
Breaking Medicine Technology: