Navigation Links
Experimental Drug Causes Cytokine Storm

A clinical trail with an experimental drug designed to treat chronic inflammatory conditions and leukemia resulted in an immune system overreaction leading// to six British men involved in the trail becoming seriously ill. All the six men have since recovered from the drug reaction.

Dr. Ganesh Suntharalingam and colleagues at Northwick Park Hospital in northwest London said the immune system overreaction, known as a cytokine storm, was an unforeseeable consequence of taking the drug.

In the New England Journal of Medicine, the doctors have noted that their case will help understand what happens when immune system overreacts, which might well again happen in future clinical trails.

Six of the eight men involved in the trail became ill shortly after they were given infusions of TGN1412, a drug engineered to affect immune system cells known as CD28 cells.

The drug made by made by German biotechnology firm TeGenero AG were given to six men who were paid volunteers in a study being run by U.S. drug research company Parexel International Corp on behalf of TeGenero.

While two of the men involved in the trial got a dummy infusion, six others who got the drug reported headaches, shivers, nausea, diarrhea and lower back pain within 90 minutes of taking the drug.

One of the patients involved in the trail became so ill that he had to be put on the ventilator following which the doctors decided to put the others also into intensive care. This was followed by a dramatic two weeks during which the previously healthy men developed difficulty in breathing and had symptoms that looked like a serious sepsis infection.

Initially, the doctors struggled to keep the men going as they tried to figure out what had gone wrong until the blood test showed that they had a cytokine storm. Such over-response of the immune system has been described in patients with avian influenza. It took two weeks for the pat ients to stabilize and recover.

"Regulatory authorities, who tested TGN1412 from the same batch as the infused drug, found no errors in its manufacture, formulation, or administration and found no contamination," the researchers added.


'"/>




Related medicine news :

1. Experimental treatment for Ebola Virus Shows promising results in mice
2. Experimental drug to fight flu
3. Experimental SARS Vaccine
4. Experimental vaccine for shingles is effective
5. Experimental Blood Test May Spot Heart Attack Risk, Study Says
6. Five AIDS Patients To Receive Experimental Anti-retroviral Drugs
7. Protection against HIV and Herpes is possible with the Experimental Microbicide
8. Experimental Therapy Effective Against Malignant Melanoma in Horses
9. Experimental Alzheimer’s Drug curbs the disease in mic
10. New Guidelines to Be Laid While Testing Experimental Drugs
11. Experimental Drug Deals Effectively with Prostate Cancer Cells
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2017)... CA (PRWEB) , ... May 23, 2017 , ... London, ... was honored to serve earlier this month as a Guest Speaker and Contributor to ... British Royal Family and Common Purpose. , Walter Schindler and ...
(Date:5/23/2017)... ... May 23, 2017 , ... By all indications, and due to months ... officials call for diligence, asking homeowners to scout for any open water sources that ... with the annoying buzz of mosquitos is the buzz associated with potential infections stemming ...
(Date:5/23/2017)... ... May 23, 2017 , ... MedTech ... in the modern ART laboratory, to provide hands-on training utilizing cutting-edge equipment at ... NextGen LifeLabs, a MedTech Group Purchasing vendor , will provide specialized equipment ...
(Date:5/23/2017)... ... May 23, 2017 , ... New patients from Charleston, SC, are ... dentist practicing in Mt. Pleasant, SC, with or without a referral. A full mouth ... with missing teeth in Charleston, SC. Those who suffer from gum disease, ...
(Date:5/23/2017)... CA (PRWEB) , ... May 23, 2017 , ... New ... gums and chronic bad breath, can now receive laser gum disease treatments from the ... Douglas Campbell and David Landau are raising awareness of the importance of receiving qualified ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)...  Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ... focused on the development of oral drug delivery ... Office has granted Oramed a patent titled, "Methods ... patent covers Oramed,s invention of an oral glucagon-like ... incretin hormone that stimulates the secretion of insulin ...
(Date:5/6/2017)... IRVING, Texas , May 5, 2017   Provista ... 1994 with more than 200,000 customers, today announced Jim ... brings a wealth of executive and business experience to Provista, ... a compounding pharmacy in California . He ... "Jim is a great fit for Provista," says ...
(Date:5/4/2017)... , May 4, 2017  A recent study ... Ultraviolet-C light as a means of ... ability to reduce bioburden on anesthesia workstations. In ... on high-touch, complex medical equipment surfaces contaminated with ... "This study further validates the body ...
Breaking Medicine Technology: