Navigation Links
Experimental Drug Causes Cytokine Storm

A clinical trail with an experimental drug designed to treat chronic inflammatory conditions and leukemia resulted in an immune system overreaction leading// to six British men involved in the trail becoming seriously ill. All the six men have since recovered from the drug reaction.

Dr. Ganesh Suntharalingam and colleagues at Northwick Park Hospital in northwest London said the immune system overreaction, known as a cytokine storm, was an unforeseeable consequence of taking the drug.

In the New England Journal of Medicine, the doctors have noted that their case will help understand what happens when immune system overreacts, which might well again happen in future clinical trails.

Six of the eight men involved in the trail became ill shortly after they were given infusions of TGN1412, a drug engineered to affect immune system cells known as CD28 cells.

The drug made by made by German biotechnology firm TeGenero AG were given to six men who were paid volunteers in a study being run by U.S. drug research company Parexel International Corp on behalf of TeGenero.

While two of the men involved in the trial got a dummy infusion, six others who got the drug reported headaches, shivers, nausea, diarrhea and lower back pain within 90 minutes of taking the drug.

One of the patients involved in the trail became so ill that he had to be put on the ventilator following which the doctors decided to put the others also into intensive care. This was followed by a dramatic two weeks during which the previously healthy men developed difficulty in breathing and had symptoms that looked like a serious sepsis infection.

Initially, the doctors struggled to keep the men going as they tried to figure out what had gone wrong until the blood test showed that they had a cytokine storm. Such over-response of the immune system has been described in patients with avian influenza. It took two weeks for the pat ients to stabilize and recover.

"Regulatory authorities, who tested TGN1412 from the same batch as the infused drug, found no errors in its manufacture, formulation, or administration and found no contamination," the researchers added.


Related medicine news :

1. Experimental treatment for Ebola Virus Shows promising results in mice
2. Experimental drug to fight flu
3. Experimental SARS Vaccine
4. Experimental vaccine for shingles is effective
5. Experimental Blood Test May Spot Heart Attack Risk, Study Says
6. Five AIDS Patients To Receive Experimental Anti-retroviral Drugs
7. Protection against HIV and Herpes is possible with the Experimental Microbicide
8. Experimental Therapy Effective Against Malignant Melanoma in Horses
9. Experimental Alzheimer’s Drug curbs the disease in mic
10. New Guidelines to Be Laid While Testing Experimental Drugs
11. Experimental Drug Deals Effectively with Prostate Cancer Cells
Post Your Comments:

(Date:11/26/2015)... ... November 26, 2015 , ... Inevitably when people think Thanksgiving, ... choose to buy during the Black Friday and Cyber Monday massage chair sales ... search the Internet high and low to find the best massage chair deals, they ...
(Date:11/26/2015)... ... November 26, 2015 , ... PRMA Plastic Surgery is updating their ... surgeons performed their 6,000th free flap breast reconstruction surgery! , “What an accomplishment for ... excited to rebuild lives and it’s an honor to have served all of these ...
(Date:11/25/2015)... ... November 25, 2015 , ... Additional breast cancers found with ... according to a study published online in the journal Radiology. Researchers said that ... necessitate a change in treatment. , Breast MRI is the most sensitive technique ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... factory direct sauna parts and accessories. , Sauna accessories help improve the bather ... style and personality. From basic styles for the purist looking for simplicity in ...
(Date:11/25/2015)... ... November 25, 2015 , ... According to an article published ... and more widely heralded as a breakthrough for performing hernia repairs. The article explains ... laparoscopic surgery is that it can greatly reduce the pain that a patient might ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)...  The total global healthcare industry is expected to grow ... Latin America has the highest projected growth at ... Japan ), is second with growth projected at 11.5%. ... healthcare expenditure. In 2013-2014, total government funded healthcare was nearly ... to 41.2% in 2013-2014. In real terms, out of pocket ...
(Date:11/25/2015)... , Nov. 25, 2015 AAIPharma Services ... investment of at least $15.8  Million to expand ... Wilmington, NC . The expansion will provide ... meet the growing demands of the pharmaceutical and ... site expansion will provide up to 40,000 square ...
(Date:11/25/2015)... Israel , November 25, 2015 ... KTOV ) (TASE: KTOV), a biopharmaceutical company focused ... treatment of various clinical conditions, today announced the closing ... American Depository Shares ( ADSs ), each representing 20 ... up to 3,158,900 ADSs. The ADSs and warrants were ...
Breaking Medicine Technology: