Navigation Links
Excessive RAMP1 Protein may Cause Migraines

A recent study has attempted to explain why some people get migraine headaches while others do not.//

The researchers found that too much of a small protein called RAMP1 appears to amplify a nerve cell receptor's response to a neuropeptide.

The neuropeptide is called CGRP (calcitonin gene-related peptide) and studies have shown that it plays a key role in migraine headaches. In particular, CGRP levels are elevated in the blood during migraine, and drugs that either reduce the levels of CGRP or block its action significantly reduce the pain of migraine headaches. Also, if CGRP is injected into people who are susceptible to migraines, they get a severe headache or a full migraine.

The UI study findings are published in the March 7 issue of the Journal of Neuroscience.

"We have shown that this RAMP protein is a key regulator for the action of CGRP," said Andrew Russo, Ph.D., UI professor of molecular physiology and biophysics. "Our study suggests that people who get migraines may have higher levels of RAMP1 than people who don't get migraines."

RAMP1 is a normal, required subunit of the CGRP receptor. Russo and his colleagues found that overexpression of RAMP1 protein in nerve cells increased the sensitivity and responsiveness of CGRP receptors to the neuropeptide -- more RAMP1 made CGRP receptors react to much lower concentrations of CGRP than usual and caused the receptors to respond more vigorously to the neuropeptide.

The UI team also engineered mice to express human RAMP1 in their nervous system in addition to the normal mouse version of the protein. These mice had double the amount of inflammation in response to CGRP than did normal mice. Nerve-induced inflammation is one of the effects associated with migraine headache.

Russo explained that his study raises the possibility that people who have migraines may have subtle genetic differences in the RAMP1 gene that result in increas
'"/>




Page: 1 2

Related medicine news :

1. Excessive use of antibiotics for sore throat
2. Good News For Those Suffering From Excessive Sweating
3. Excessive Day time sleep may be linked to depression or diabetes
4. Excessive Belly Fat Could Increase Risk Of Gallstones In Women
5. Excessive Alcohol Consumption May Cause Ill health Of The GI System
6. Health Canada Warns Against Excessive Consumption Of Lobster Tomalleys
7. Excessive Text Messaging Causes Repetitive Strain Injury In A Eight Year Old Girl
8. Excessive exercise common among women with eating disorders
9. Excessive Dietary Fat can Lead to Asthma
10. Excessive Drinking Cuts Life Span
11. Excessive Male Hormones can Cause Bulimia in Women
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Excessive RAMP1 Protein may Cause Migraines

(Date:9/21/2014)... NY (PRWEB) September 21, 2014 ... develops, implements and supports electronic medical records (EMR) ... benefited from federal healthcare legislation during the past ... do so during the five years to 2019. ... Clinical Health Act established Medicare and Medicaid incentives ...
(Date:9/21/2014)... Market Research Report on ... 2009-2019 is a professional and in-depth market ... 49562-28-9) industry. The report firstly reviews the ... its classification, application and manufacturing technology.The report ... of Fenofibrate (CAS 49562-28-9) listing their product ...
(Date:9/21/2014)... Chicago, IL (PRWEB) September 21, 2014 ... pain is so intense and difficult to resolve,” said ... and I can't think of a pain that is ... everyone who suffers from cluster headaches, or migraines, that ... based on the serotonin system,” he added. , Serotonin ...
(Date:9/21/2014)... 21, 2014 According to latest National ... birth rate since 1966 (10.5 births per 1,000 women in ... 40s has risen steadily by 2 percent per year. The ... women aged 50 and over) also rose, the first such ... more than nine times as many first births to women ...
(Date:9/20/2014)... September 21, 2014 Weight Destroyer ... by fitness expert Michael Wren that has already helped ... and reverse health conditions like high blood pressure, high ... Shane Michaels, prompting an investigative review. , “Weight ... tips upside down by showing people what is truly ...
Breaking Medicine News(10 mins):Health News:Electronic Medical Records Systems in the US Industry Market Research Report Now Available from IBISWorld 2Health News:Electronic Medical Records Systems in the US Industry Market Research Report Now Available from IBISWorld 3Health News:Electronic Medical Records Systems in the US Industry Market Research Report Now Available from IBISWorld 4Health News:Fenofibrate Industry Global and Chinese Analysis for 2014-2019 Now Available at LifeScienceIndustryResearch.com 2Health News:Fenofibrate Industry Global and Chinese Analysis for 2014-2019 Now Available at LifeScienceIndustryResearch.com 3Health News:Fenofibrate Industry Global and Chinese Analysis for 2014-2019 Now Available at LifeScienceIndustryResearch.com 4Health News:Homeostasis: Equinox Serotonin (5HT) Headache Stories ~ New on the Bryan William Brickner Blog 2Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 2Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 3Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 4Health News:Weight Destroyer: Review Exposes Michael Wren’s Guide to Effective Weight Loss and Improved Health 2Health News:Weight Destroyer: Review Exposes Michael Wren’s Guide to Effective Weight Loss and Improved Health 3
... cancer patients treated in hospitals that care for ... so-called "high safety-net burden facilities," were significantly less ... cure the cancer compared to patients treated at ... after controlling for other factors that significantly decreased ...
... Allan Coukell, a pharmacist and director of medical programs ... Senate Health Education Labor and Pensions Committee about the ... the U.S. drug supply. Nearly 80 ... U.S. Increasingly, Americans rely on pharmaceuticals that are ...
... By Steven Reinberg HealthDay Reporter , ... the U.S. Food and Drug Administration were to meet ... bone-building drugs such as Fosamax, Actonel, Boniva and Reclast. ... to prevent fractures related to postmenopausal osteoporosis. But researchers ...
... HealthDay Reporter , THURSDAY, Sept. 8 (HealthDay News) -- Women ... somewhat more likely than teetotalers to be in good physical ... The study doesn,t prove that moderate drinking will lead to ... other factors could account for the difference. Also, the research ...
... doses of the human papillomavirus (HPV) vaccine Cervarix may be ... comes to preventive measures against cervical cancer, according to a ... of the National Cancer Institute . Across the globe, ... and HPV types 16 and 18 are a large contributor ...
... OTTAWA Sept. 8, 2011 Researchers at the ... an ancient pathway called autophagy also mobilizes and exports ... Yves Marcel, PhD, Director of the HDL Biology Laboratory, ... evolution, functions to engulf and digest cholesterol accumulated in ...
Cached Medicine News:Health News:Study finds hospitals of last resort deliver lower quality of lung cancer care 2Health News:Osteoporosis Drugs' Safety Subject of FDA Panel 2Health News:Osteoporosis Drugs' Safety Subject of FDA Panel 3Health News:For Women, Moderate Midlife Drinking Linked to Healthier Old Age 2Health News:Fewer than 3 doses of cervical cancer vaccine effective 2Health News:Researchers find process that clears cholesterol and could reverse major cause of heart attack 2
(Date:9/19/2014)...  4WEB Medical announces the formal launch of the ... implants on the market today at this weekend,s ... Chicago .  The Osteotomy Truss System is ... with 74 size options included in one versatile set. ... 15 to 18 implant sizes, which limited a surgeon,s ...
(Date:9/19/2014)... 19, 2014 The American Association for Homecare ... and Manufacturing has joined the AAHomecare Corporate Partner Program. ... Diamond have been actively involved in AAHomecare for ... has quickly grown into a major global manufacturer of ... allows AAHomecare to increase efforts on behalf of the ...
(Date:9/19/2014)... -- Five MinuteClinic walk-in medical clinics are opening inside select CVS/pharmacy ... clinics opened in Memphis and ... added in Springfield on September 24 and ... to open October 22.  MinuteClinic is the largest and fastest growing ... . The Memphis -area clinics ...
Breaking Medicine Technology:4WEB Medical Unveils 3D-Printed Osteotomy Truss System 2Drive Medical Design & Manufacturing Joins AAHomecare Corporate Partner Program 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 3
... Phase 1 Clinical Trial Results Disclosed, ... Inc., a,biopharmaceutical company developing "Best-in-Class" drugs for ... that the results,of multiple studies on its ... will be presented in eighteen presentations at ...
... CeNeRx BioPharma,Inc., a clinical stage company developing and ... system, today announced that,it has initiated a Phase ... for the treatment of major depressive disorder (MDD). ... novel class of drugs known as RIMAs,or reversible ...
Cached Medicine Technology:Trius Antibiotics to be Highlighted in 18 Presentations at ICAAC/IDSA 2Trius Antibiotics to be Highlighted in 18 Presentations at ICAAC/IDSA 3CeNeRx BioPharma Initiates Phase II Clinical Trial of Its Novel Antidepressant Agent Tyrima(TM) 2CeNeRx BioPharma Initiates Phase II Clinical Trial of Its Novel Antidepressant Agent Tyrima(TM) 3
... Bio-Quant S. typhi rapid test is ... The test employs a conation of ... polyclonal antibody immobilized on the solid ... typhi,antigen associated Salmonella typhi (typhoid) infection ...
... InstaTest Mono is an immunochromatographic in ... associated with,infectious mononucleosis infection.,Infectious mononucleosis (IM) ... diagnosis of IM is based on ... infection, such as the,heterophile antibodies present ...
OneStep Midstream Urine hCG Pregnancy InstaTest is a test kit for the determination of hCG(Human Chorionic Gonadotropin) in urine specimens. This test kit is used to obtain a visual, qualitative resu...
... Myoglobin Insta Test is an ... test. It is designed for ... serum specimens. The presence of ... ng/mL or higher can be ...
Medicine Products: