Navigation Links
Excess Cdk5 Enzyme Can Harm Brain

A research conducted by the Howard Hughes Medical Institute, the National Institute of Mental Health and the Harvard Medical School has revealed that a brain enzyme plays a prominent role// in maintaining and developing learning and memory. If the enzyme is present in high levels, then it can have adverse effects on the brain. The tests were conducted on mice. The Cdk5 enzyme also plays an important role in the death of neurons in disorders like the Alzheimer's disease.

According to the researchers' studies, increased levels of Cdk5, as well as increased levels of a regulatory protein called p25 that is known to hyper-activate Cdk5, had been found in the brains of patients suffering from Alzheimer’s. In the study, the researchers used mice in which they could switch on p25 at will in the brain's learning and memory center, the hippocampus. It was found that while in the mice in which p25 was switched on for only two weeks, actually enhanced learning and memory, in contrast, mice in which p25 had been switched on for six weeks showed impaired learning and memory in certain tasks.

The researchers said that this indicated that elevated levels of p25 impaired learning and memory. This indicates that transient p25 production facilitated learning, whereas the ability to form new memories was impaired by prolonged p25 expression, according to the researchers said. The study showed that it was possible that chronic exposure to Alzheimer’s risk factors would increase the p25 to a level that would contribute to neural loss.

The researchers said that the increase in p25 levels might be a mechanism to compensate for the damage from such diseases like Alzheimer’s. This may cause the enzyme, whose work it was to stop degeneration, actually quicken the process. The evidence that is provided by the study is that the p25 generation might be a compensatory phenomenon to enhance neuroplasticity. These mice may also serve as a model whereby a facto r that promotes plasticity can eventually contribute to neurodegeneration according to the researchers. (ANI)
'"/>




Related medicine news :

1. Excessive use of antibiotics for sore throat
2. Excess vitamin A increases fracture risk
3. Excess Weight Can Affect Individuals as They Age
4. Excess physical activity can induce stress fracture in adolescent girls
5. Good News For Those Suffering From Excessive Sweating
6. Excessive Day time sleep may be linked to depression or diabetes
7. Excess Intake of Alcohol Results in Permanent DNA Damage.
8. Excess of anything, even Vitamin D found to be harmful
9. Excessive Belly Fat Could Increase Risk Of Gallstones In Women
10. Doctors Drained Excess Fluids From Sharons Abdominal Cavity
11. Oral Medicine Found To Remove Excess Iron in the Body
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/12/2016)... ... February 12, 2016 , ... Atlantic Information Services, Inc. (AIS) ... PBMs,” an upcoming Feb. 24 webinar that will discuss ways health plans and ... such as the $1,000-per-pill hepatitis C treatment Sovaldi and high-cost PCSK9 inhibitors to ...
(Date:2/12/2016)... ... February 12, 2016 , ... US Sport Camps is pleased to ... Club, located in Norwalk, serves as the host site and directing the camps is ... “We have had successful camps in recent years around Des Moines and are fortunate ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Healthcare careers in ... five most searched jobs via the website of healthcare staffing leader Aureus Medical Group ... travel nurse jobs , travel therapy positions and in travel and direct ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... ... creating explosive growth in the field of long term care. With that, says ... for well-trained healthcare professionals in administrative roles in long term care environments. His ...
(Date:2/12/2016)... ... February 12, 2016 , ... Basketball is a game for everyone, not just ... PoppersTM series, sign language translation is featured in the top right of the screen. ... PoppersTM lessons has a sign language translator to teach kids the game and how ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Stem cells are primitive cells found in ... the capacity to differentiate into mature cell types Stem ... first mouse embryonic stem cells were derived from embryos ... the first culturing of embryonic stem cells from non-human ... until 2006 As a result of these discoveries, stem ...
(Date:2/11/2016)... N.Y. , Feb. 11, 2016  Governor Andrew ... that will create 1,400 jobs throughout Western ... a partnership with the SUNY Polytechnic Institute, includes a ... Conventus Building in Buffalo , as ... foot manufacturing facility in Dunkirk . ...
(Date:2/11/2016)... AAIPharma Services Corp./Cambridge Major Laboratories, Inc. ... development services for the pharmaceutical and biotechnology industries, ... in its Charleston, SC ... recent investments. Charleston ... with small-scale lyophilization. The site has invested in ...
Breaking Medicine Technology: