Navigation Links
Excess Cdk5 Enzyme Can Harm Brain

A research conducted by the Howard Hughes Medical Institute, the National Institute of Mental Health and the Harvard Medical School has revealed that a brain enzyme plays a prominent role// in maintaining and developing learning and memory. If the enzyme is present in high levels, then it can have adverse effects on the brain. The tests were conducted on mice. The Cdk5 enzyme also plays an important role in the death of neurons in disorders like the Alzheimer's disease.

According to the researchers' studies, increased levels of Cdk5, as well as increased levels of a regulatory protein called p25 that is known to hyper-activate Cdk5, had been found in the brains of patients suffering from Alzheimer’s. In the study, the researchers used mice in which they could switch on p25 at will in the brain's learning and memory center, the hippocampus. It was found that while in the mice in which p25 was switched on for only two weeks, actually enhanced learning and memory, in contrast, mice in which p25 had been switched on for six weeks showed impaired learning and memory in certain tasks.

The researchers said that this indicated that elevated levels of p25 impaired learning and memory. This indicates that transient p25 production facilitated learning, whereas the ability to form new memories was impaired by prolonged p25 expression, according to the researchers said. The study showed that it was possible that chronic exposure to Alzheimer’s risk factors would increase the p25 to a level that would contribute to neural loss.

The researchers said that the increase in p25 levels might be a mechanism to compensate for the damage from such diseases like Alzheimer’s. This may cause the enzyme, whose work it was to stop degeneration, actually quicken the process. The evidence that is provided by the study is that the p25 generation might be a compensatory phenomenon to enhance neuroplasticity. These mice may also serve as a model whereby a facto r that promotes plasticity can eventually contribute to neurodegeneration according to the researchers. (ANI)
'"/>




Related medicine news :

1. Excessive use of antibiotics for sore throat
2. Excess vitamin A increases fracture risk
3. Excess Weight Can Affect Individuals as They Age
4. Excess physical activity can induce stress fracture in adolescent girls
5. Good News For Those Suffering From Excessive Sweating
6. Excessive Day time sleep may be linked to depression or diabetes
7. Excess Intake of Alcohol Results in Permanent DNA Damage.
8. Excess of anything, even Vitamin D found to be harmful
9. Excessive Belly Fat Could Increase Risk Of Gallstones In Women
10. Doctors Drained Excess Fluids From Sharons Abdominal Cavity
11. Oral Medicine Found To Remove Excess Iron in the Body
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... June 27, 2016 , ... ... payment industry today announced its strategic partnership with Connance, a healthcare industry ... The two companies’ proven, proprietary technology combine to provide health systems, hospitals ...
(Date:6/27/2016)... Park, KS (PRWEB) , ... June 27, 2016 , ... ... in retailers of Eyeglasses . , Millions of individuals in the United States ... eyeglasses have become a way to both correct vision and make a fashion statement. ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, a ... and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is ... to some of the world’s leading providers of cereal and other breakfast foods. Its ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... PawPaws ... a new product that was developed to enhance the health of felines. The formula ... , The two main herbs in the PawPaws Cat Kidney Support Supplement ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many ... been diagnosed with endometriosis. These women need a treatment plan to not only ... approach that can help for preservation of fertility and ultimately achieving a pregnancy. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
(Date:6/24/2016)... NAMUR , Belgium , ...  (NYSE MKT: VNRX), today announced the appointment of ... Board of Directors as a Non-Executive Director, effective ... the Company,s Audit, Compensation and Nominations and Governance ... Board, Dr. Futcher will provide independent expertise and ...
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
Breaking Medicine Technology: