Navigation Links
Excess Cdk5 Enzyme Can Harm Brain

A research conducted by the Howard Hughes Medical Institute, the National Institute of Mental Health and the Harvard Medical School has revealed that a brain enzyme plays a prominent role// in maintaining and developing learning and memory. If the enzyme is present in high levels, then it can have adverse effects on the brain. The tests were conducted on mice. The Cdk5 enzyme also plays an important role in the death of neurons in disorders like the Alzheimer's disease.

According to the researchers' studies, increased levels of Cdk5, as well as increased levels of a regulatory protein called p25 that is known to hyper-activate Cdk5, had been found in the brains of patients suffering from Alzheimer’s. In the study, the researchers used mice in which they could switch on p25 at will in the brain's learning and memory center, the hippocampus. It was found that while in the mice in which p25 was switched on for only two weeks, actually enhanced learning and memory, in contrast, mice in which p25 had been switched on for six weeks showed impaired learning and memory in certain tasks.

The researchers said that this indicated that elevated levels of p25 impaired learning and memory. This indicates that transient p25 production facilitated learning, whereas the ability to form new memories was impaired by prolonged p25 expression, according to the researchers said. The study showed that it was possible that chronic exposure to Alzheimer’s risk factors would increase the p25 to a level that would contribute to neural loss.

The researchers said that the increase in p25 levels might be a mechanism to compensate for the damage from such diseases like Alzheimer’s. This may cause the enzyme, whose work it was to stop degeneration, actually quicken the process. The evidence that is provided by the study is that the p25 generation might be a compensatory phenomenon to enhance neuroplasticity. These mice may also serve as a model whereby a facto r that promotes plasticity can eventually contribute to neurodegeneration according to the researchers. (ANI)
'"/>




Related medicine news :

1. Excessive use of antibiotics for sore throat
2. Excess vitamin A increases fracture risk
3. Excess Weight Can Affect Individuals as They Age
4. Excess physical activity can induce stress fracture in adolescent girls
5. Good News For Those Suffering From Excessive Sweating
6. Excessive Day time sleep may be linked to depression or diabetes
7. Excess Intake of Alcohol Results in Permanent DNA Damage.
8. Excess of anything, even Vitamin D found to be harmful
9. Excessive Belly Fat Could Increase Risk Of Gallstones In Women
10. Doctors Drained Excess Fluids From Sharons Abdominal Cavity
11. Oral Medicine Found To Remove Excess Iron in the Body
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed ... geared towards children of all ages; it is a non-competitive, non-timed event, which is ...
(Date:10/13/2017)... ... 13, 2017 , ... “The Journey: From the Mountains to the Mission Field”: ... souls in the Philippines. “The Journey: From the Mountains to the Mission Field” is ... Bible. She has taught all ages and currently teaches a class of ladies at ...
(Date:10/12/2017)... ... ... Planet Fitness, one of the largest and fastest growing franchisors and operators ... location in Covington, LA at 401 N. U.S. Highway 190, in January of 2018. ... in the Holiday Square shopping center. Its location allows it to serve both Covington ...
(Date:10/12/2017)... ... , ... Asante, a nationally recognized health system in southern ... home health joint venture through an agreement, effective October 1, 2017, to create ... health company with Asante, delivering clinically integrated care, for the past eight years. ...
(Date:10/12/2017)... ... 2017 , ... Leading pediatric oncology experts at Children’s National Health System ... Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by ... and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., ... vaccine design, and immune-engineering today announced the launch ... the development of personalized therapeutic cancer vaccines. EpiVax ... provided exclusive access to enabling technologies to the ... MBA will lead EpiVax Oncology as Chief Executive ...
(Date:9/19/2017)... Sept. 19, 2017   ZirMed Inc ., a recognized ... announced that it has been ranked #1 by its users ... Rankings 2017 User Survey. ZirMed was recognized as the ... hospitals and medical centers over 200 beds and holds one ... technology user survey history. ...
(Date:9/12/2017)... , Sept. 12, 2017  Consumer reviews on the independent review ... as the number one company for hearing aids, ranking it higher ... other brands. ... Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that provides high performance, state-of-the-art, ...
Breaking Medicine Technology: