Navigation Links
Evoprinter, a multigenomic comparative tool for rapid identification of functionally important DNA

Deciphering the regulatory mechanisms that control coordinate gene expression is a long-standing goal of biology. The comparison of orthologous DNA sequences from multiple vertebrate or invertebrate // species holds promise in identifying the cis-regulatory elements central to the dynamic interplay between a gene and its transcriptional regulators. This cross-species comparison, termed phylogenetic footprinting, is based on the hypothesis that functionally important sequences evolve at a significantly slower rate than nonfunctional DNA. Phylogenetic footprinting has been used successfully to discover multispecies-conserved sequences (MCSs) that are critical for gene function. An essential first step in this process is the alignment of multiple orthologous DNAs. The multiDNA alignments are accomplished either by simultaneous or sequential pair wise alignments of input DNAs, with alignment gaps introduced to optimize the overall homology comparisons.

Researchers, writing in the October issue of the Proceedings of the National Academy of Sciences have developed a simple, yet effective, comparative genomics tool, Evoprinter that facilitates the rapid identification of evolutionary conserved sequences within the context of a single species. The Evoprinter output identifies multispecies-conserved DNA sequences as they exist in a reference DNA.

Generated from multiple pair wise BLAT (BLAST-like alignment tool) alignments of a reference DNA to different test genomes, the EvoP presents an ordered, uninterrupted representation of the evolutionarily resilient sequences within the reference DNA. By superimposing the different species evolutionary histories, the combined mutagenic force reveals DNA sequences that are essential for gene expression and function. When compared with other such tools, the two principal advantages of Evoprinter are its speed (derived from the speed of a BLAT alignment) and the fact that only a single curated genomic sequence is requ ired to initiate the analysis of orthologous DNAs from multiple species. Based on the success of the Evoprinter identification of MCSs within known vertebrate and Drosophila cis-regulatory elements, the authors believe that this tool could be of great use to understanding gene regulation in all animals.


'"/>




Related medicine news :

1. Breastfed babies grow rapidly
2. Early identification of autism possible
3. Computer aided cancer identification in young women
4. MRI can predict risk of cardiac arrhythmia by identification of scar tissue
5. Headway in identification of allergens of contact dermatitis
6. Antidepressants-important role
7. Inherited gene important in ovarian cancer
8. Balanced diet important in cancer prevention
9. Race an important links to the risk of advanced colorectal cancer
10. Lifestyle plays an important role in determining one’s ag
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2017)... ... June 26, 2017 , ... ... Sexual Medicine Specialists, in collaboration with the Fertility Center of California, is pleased ... PESA (percutaneous epidydimal sperm aspiration) and TESA (percutaneous testicular sperm extraction). These minimally ...
(Date:6/26/2017)... , ... June 26, 2017 , ... ... staff, and consumers are seeing lots of red these days. According to recent ... charges that result from medical coding errors(1). Some studies point to Electronic Health ...
(Date:6/25/2017)... ... ... in the United States Senate on Thursday released their version of bill ... from the American Health Care Act, which the House passed in May, so the ... to take up the Senate version as-is, if it passes. , The following statements ...
(Date:6/24/2017)... ... June 24, 2017 , ... Genes Advice, a new ... select Florida and Texas doctors' offices and clinics. This breakthrough testing is part ... testing recognizes the role genes play in determining an individual's tolerance of and ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Rhode Island Quality ... Management Alerts and Dashboards, an innovative new service enabling healthcare providers to proactively ... Management Alerts and Dashboards provide near real-time data about patients admitted to and/or ...
Breaking Medicine News(10 mins):
(Date:6/20/2017)... and LAGUNA HILLS, Calif. , ... of new data that validate the use of MMprofiler ... patients with multiple myeloma (MM). In a poster presentation ... Hematology Association (EHA) in Madrid, Spain ... MMprofiler for identifying high-risk elderly patients. ...
(Date:6/16/2017)... 50 years ago today, the Monterey Pop Festival opened its ... San Francisco "Summer of Love."  To celebrate the anniversary, Northern ... strategic market research portals that it will begin delivering to ... Light,s "Summer of Love (For Our Customers)."  ... Northern ...
(Date:6/13/2017)... , June 13, 2017 Zimmer Biomet Holdings, Inc. ... today announced that the U.S. Food and Drug Administration (FDA) ... 3, 2015 relating to its Zhejiang, China ... "The successful clearance of the Warning Letter ... manufacturing facility is a measure of the progress we have ...
Breaking Medicine Technology: