Navigation Links
Evoprinter, a multigenomic comparative tool for rapid identification of functionally important DNA

Deciphering the regulatory mechanisms that control coordinate gene expression is a long-standing goal of biology. The comparison of orthologous DNA sequences from multiple vertebrate or invertebrate // species holds promise in identifying the cis-regulatory elements central to the dynamic interplay between a gene and its transcriptional regulators. This cross-species comparison, termed phylogenetic footprinting, is based on the hypothesis that functionally important sequences evolve at a significantly slower rate than nonfunctional DNA. Phylogenetic footprinting has been used successfully to discover multispecies-conserved sequences (MCSs) that are critical for gene function. An essential first step in this process is the alignment of multiple orthologous DNAs. The multiDNA alignments are accomplished either by simultaneous or sequential pair wise alignments of input DNAs, with alignment gaps introduced to optimize the overall homology comparisons.

Researchers, writing in the October issue of the Proceedings of the National Academy of Sciences have developed a simple, yet effective, comparative genomics tool, Evoprinter that facilitates the rapid identification of evolutionary conserved sequences within the context of a single species. The Evoprinter output identifies multispecies-conserved DNA sequences as they exist in a reference DNA.

Generated from multiple pair wise BLAT (BLAST-like alignment tool) alignments of a reference DNA to different test genomes, the EvoP presents an ordered, uninterrupted representation of the evolutionarily resilient sequences within the reference DNA. By superimposing the different species evolutionary histories, the combined mutagenic force reveals DNA sequences that are essential for gene expression and function. When compared with other such tools, the two principal advantages of Evoprinter are its speed (derived from the speed of a BLAT alignment) and the fact that only a single curated genomic sequence is requ ired to initiate the analysis of orthologous DNAs from multiple species. Based on the success of the Evoprinter identification of MCSs within known vertebrate and Drosophila cis-regulatory elements, the authors believe that this tool could be of great use to understanding gene regulation in all animals.


'"/>




Related medicine news :

1. Breastfed babies grow rapidly
2. Early identification of autism possible
3. Computer aided cancer identification in young women
4. MRI can predict risk of cardiac arrhythmia by identification of scar tissue
5. Headway in identification of allergens of contact dermatitis
6. Antidepressants-important role
7. Inherited gene important in ovarian cancer
8. Balanced diet important in cancer prevention
9. Race an important links to the risk of advanced colorectal cancer
10. Lifestyle plays an important role in determining one’s ag
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... (PRWEB) , ... June 27, ... ... in the patient payment industry today announced its strategic partnership with Connance, ... system workflows. , The two companies’ proven, proprietary technology combine to provide ...
(Date:6/26/2016)... ... , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing Effect ... a whole new perspective by using the title layers in ProSlice Levels to ... ProSlice Levels contains over 30 Different presets to choose from. FCPX users ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Austin residents ... the American College of Mohs Surgery and to Dr. Russell Peckham for medical and ... highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin ... injury. Recently, he has implemented orthobiologic procedures as a method for treating his ... of the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 26, 2016 Story ... operating models within the health care industry is causing ... efficiency , Deloitte offers a suite of solutions ... issues impacting efficient cost optimization: labor resource analysis, revenue ... services facilitate better outcomes and better economics ...
(Date:6/24/2016)... 24, 2016 ... the addition of the " Global Markets for ... This report focuses on ... updated review, including its applications in various applications. The ... which includes three main industries: pharmaceutical and biotechnology, food ...
(Date:6/24/2016)... Research and Markets has announced the addition of the ... to their offering. ... World Market for Companion Diagnostics covers the world market for ... report includes the following: , World IVD ... (N. America, EU, ROW), 2015-2020 , World IVD Companion ...
Breaking Medicine Technology: