Navigation Links
Evidence against use of Beta blockers as first choice in the treatment of primary hypertension

Beta blockers have been used widely in the treatment of hypertension and are still recommended as first-line drugs in hypertension guidelines. Moreover, after myocardial infarction and in patients with heart failure, treatment // with beta blockers prevents re-infarction, hospitalisation for heart failure, and premature death. However, a preliminary analysis has shown that atenolol is not very effective in hypertension.

A recent study, published in the October-November issue of The Lancet, was conducted with the aim to substantially enlarge previous data on atenolol and analyse the effect of different beta blockers on stroke, myocardial infarction, and mortality of all causes .

For the study, the Cochrane Library and PubMed were searched for beta blocker treatment in patients with primary hypertension. Data were then entered into the Cochrane Collaboration Review Manager package and were summarised in meta-analyses. 13 randomised controlled trials were included in a meta-analysis comparing treatment with beta blockers with other antihypertensive drugs. Seven studies were included in a comparison of beta blockers and placebo or no treatment..

Results obtained showed that the relative risk of stroke was 16% higher for beta blockers than for other drugs. There was no difference for myocardial infarction. When the effect of beta blockers was compared with that of placebo or no treatment, the relative risk of stroke was reduced by 19% for all beta blockers, about half that expected from previous hypertension trials. There was no difference for myocardial infarction or mortality.

The authors conclude that in comparison with other antihypertensive drugs, the effect of beta blockers is less than optimum, with a raised risk of stroke.

The authors suggest that beta blockers should not remain first choice in the treatment of primary hypertension and should not be used as reference drugs in future randomised controlled tr ials of hypertension.


'"/>




Related medicine news :

1. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
2. Evidence supporting H.pylori eradication
3. Evidences that Better Health Care Facility is Offered By Public Hospitals.
4. First Conclusive Evidence Linking Oral Bacteria To Premature Babies
5. Study Provides Evidence That Obesity Leads To A More Aggressive Ovarian Cancer
6. No Clear Evidence for Ultra-Low Cholesterol Targets?
7. Lack of Evidence on Treatment for Narrowed Kidney Arteries
8. Some Evidence Shows Chinese Herbal Medicine Helps Angina Patients
9. Strong Evidence Suggests Incidence Of Mating Of Ancestors With Neanderthals
10. Dermatologists Provide Unique Evidence of Possible Cause of Rare Skin Condition
11. Is Evidence-based Medicine Enough to Support Additional Research in Alternative Medicine?
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/29/2016)... ... , ... Our bodies are bombarded daily by environmental and lifestyle factors that ... is to adopt a more healthful diet, but too many people think that food ... Nutritionist and the creator of the Newport Beach Cleanse and 14-Day Eating Plan, disagrees ...
(Date:4/29/2016)... , ... April 29, 2016 , ... On Tuesday, April ... across the Southeast, celebrated the signature of Gov. Nathan Deal on SB 258, the ... Duncan (R - Cumming), offers a 70% tax credit to individuals and corporations which ...
(Date:4/29/2016)... ... April 29, 2016 , ... The American workforce ... stability, even security. Most importantly, employees are the single most important asset in ... workers so unhappy? , Just under half of American workers are emotionally checked ...
(Date:4/29/2016)... ... April 29, 2016 , ... Dr. Bernie Siegel, ... "LOVE, MEDICINE and MIRACLES") addresses touchy topics related to Death live on ... Dr. Bernie Siegel, author of a plethora of essential books-to-read for physicians ...
(Date:4/29/2016)... ... April 29, 2016 , ... The White House ... their loans, more information about their loan terms and accounts, and more protections ... debt, including federal and private loans, has reached $1.3 trillion, with 43 million ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... 2016 ReportsnReports.com adds "Pulmonary ... research report that provides an overview of the ... various stages, therapeutics assessment by drug target, mechanism ... molecule type, along with latest updates, and featured ... players involved in the therapeutic development for Pulmonary ...
(Date:4/29/2016)... 2016 Acquisition Expands the ... Development Capabilities in North America ... Indegene ( http://www.indegene.com ), a ... of Skura Corporation,s life science business. Skura,s SFX ... enablement technology for life science organizations and delivers ...
(Date:4/29/2016)... , April 29, 2016 ... Directeur Financier Sanofi, leader ... publie ses résultats pour le premier ... Groupe, Jérôme Contamine, commente les résultats ... les perspectives pour le reste de ...
Breaking Medicine Technology: