Navigation Links
Evidence Links Protein Damage to Neurodegenerative diseases like Parkinson's and Alzheimer's

Neurodegenerative diseases - including Parkinson's, Alzheimer's, Diffuse Lewy body disease, and Multiple System Arophy - are collectively called synucleinopathies. Most commonly they become symptomatic due to a deficiency of a specific neurotransmitter - in the case of Parkinson's it is dopamine. When the neurons that produce these chemicals die or become impaired, which occurs with oxidation, the eventual results are tremors and sometimes dementia.

New evidence links oxidative damage in a protein found in nerve cells to the development of degenerative diseases of the nervous system, such as Parkinson's and Alzheimer's disease.

The first study to provide this evidence, conducted by University of Pennsylvania researchers, was published in the November 3, 2000, issue of Science.

The researchers said, "The protein, called alpha-synuclein, is one of the building blocks of the brain lesions characteristic in patients with neurodegenerative diseases. Oxidative damage, normally occurs when the body's cells are overwhelmed by molecules that have changed because they have combined with nitrogen (nitration) or oxygen (oxidation). Both types of oxidants damage lipids, nucleic acids, proteins, and other cellular components much like oxidation causes rust damage to metal in cars and buildings. This damage has been implicated in causing neurodegenerative disorders. Alpha-synuclein itself is a target of oxidative stress, specifically nitration, within these lesions. This is the first time anybody has identified nitration on a specific protein. Studies provide conclusive evidence of oxidative damage in alpha-synuclein, and that such stress may be a primary event leading to the onset and progression of neurodegenerative synucleinopathies, particularly Parkinson's. This may pave the way for developing therapies to stop or slow the oxidative damage, and thus slow or reverse the progression of these diseases."
'"/>




Page: 1

Related medicine news :

1. Evidence supporting H.pylori eradication
2. Evidence against use of Beta blockers as first choice in the treatment of primary hypertension
3. Evidences that Better Health Care Facility is Offered By Public Hospitals.
4. First Conclusive Evidence Linking Oral Bacteria To Premature Babies
5. Study Provides Evidence That Obesity Leads To A More Aggressive Ovarian Cancer
6. No Clear Evidence for Ultra-Low Cholesterol Targets?
7. Lack of Evidence on Treatment for Narrowed Kidney Arteries
8. Some Evidence Shows Chinese Herbal Medicine Helps Angina Patients
9. Strong Evidence Suggests Incidence Of Mating Of Ancestors With Neanderthals
10. Dermatologists Provide Unique Evidence of Possible Cause of Rare Skin Condition
11. Is Evidence-based Medicine Enough to Support Additional Research in Alternative Medicine?
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... Miami, FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton ... Plant City Observer , brings up a new, often overlooked aspect of head lice: ... The closing for fumigation is not a common occurrence, but a necessary one in the ...
(Date:6/25/2016)... ... 25, 2016 , ... First Choice Emergency Room , the largest network ... the Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased ... location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of ... of the latter, setting the bar too high can result in disappointment, perhaps even ... progress toward their goal. , Research from PsychTests.com reveals that behind ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced ... feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as a ... has released tools for healthy coping following a traumatic event. , Trauma sufferers tend ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...  Collagen Matrix, Inc., ("Collagen Matrix") the driving ... collagen and mineral based medical devices for tissue ... Messer has joined the company as Vice ... growing portfolio of oral surgery, neurosurgery, orthopaedic and ... the Collagen Matrix executive team as an accomplished ...
(Date:6/24/2016)... 2016   Bay Area Lyme Foundation , ... Center for Tick Borne Illness , Harvard Medical ... Hacking Medicine, University of California, Berkeley, and the ... five finalists of Lyme Innovation , the ... 100 scientists, clinicians, researchers, entrepreneurs, and investors from ...
(Date:6/24/2016)... -- Research and Markets has announced ... Applications, Technologies, Forecasts" report to their offering. ... Smart Skin, Structural Health Monitoring, Composite Smart Structures, ... involves electronic and/or electrical components and circuits that ... such as vehicle bodies or conformally placed upon ...
Breaking Medicine Technology: