Navigation Links
Evidence Links Protein Damage to Neurodegenerative diseases like Parkinson's and Alzheimer's

Neurodegenerative diseases - including Parkinson's, Alzheimer's, Diffuse Lewy body disease, and Multiple System Arophy - are collectively called synucleinopathies. Most commonly they become symptomatic due to a deficiency of a specific neurotransmitter - in the case of Parkinson's it is dopamine. When the neurons that produce these chemicals die or become impaired, which occurs with oxidation, the eventual results are tremors and sometimes dementia.

New evidence links oxidative damage in a protein found in nerve cells to the development of degenerative diseases of the nervous system, such as Parkinson's and Alzheimer's disease.

The first study to provide this evidence, conducted by University of Pennsylvania researchers, was published in the November 3, 2000, issue of Science.

The researchers said, "The protein, called alpha-synuclein, is one of the building blocks of the brain lesions characteristic in patients with neurodegenerative diseases. Oxidative damage, normally occurs when the body's cells are overwhelmed by molecules that have changed because they have combined with nitrogen (nitration) or oxygen (oxidation). Both types of oxidants damage lipids, nucleic acids, proteins, and other cellular components much like oxidation causes rust damage to metal in cars and buildings. This damage has been implicated in causing neurodegenerative disorders. Alpha-synuclein itself is a target of oxidative stress, specifically nitration, within these lesions. This is the first time anybody has identified nitration on a specific protein. Studies provide conclusive evidence of oxidative damage in alpha-synuclein, and that such stress may be a primary event leading to the onset and progression of neurodegenerative synucleinopathies, particularly Parkinson's. This may pave the way for developing therapies to stop or slow the oxidative damage, and thus slow or reverse the progression of these diseases."
'"/>




Page: 1

Related medicine news :

1. Evidence supporting H.pylori eradication
2. Evidence against use of Beta blockers as first choice in the treatment of primary hypertension
3. Evidences that Better Health Care Facility is Offered By Public Hospitals.
4. First Conclusive Evidence Linking Oral Bacteria To Premature Babies
5. Study Provides Evidence That Obesity Leads To A More Aggressive Ovarian Cancer
6. No Clear Evidence for Ultra-Low Cholesterol Targets?
7. Lack of Evidence on Treatment for Narrowed Kidney Arteries
8. Some Evidence Shows Chinese Herbal Medicine Helps Angina Patients
9. Strong Evidence Suggests Incidence Of Mating Of Ancestors With Neanderthals
10. Dermatologists Provide Unique Evidence of Possible Cause of Rare Skin Condition
11. Is Evidence-based Medicine Enough to Support Additional Research in Alternative Medicine?
Post Your Comments:
(Date:10/1/2014)... Between 23 million and 50 million people suffer ... from the National Institutes of Health (NIH) and the ... them have something else in common: They have a ... Gluten Free Therapeutics, makers of CeliVites nutritional supplements, ... publishing a series of blog posts aimed at educating ...
(Date:10/1/2014)... 01, 2014 Diet Doc understands that many ... lose weight and their dieting attempts could be easily sabotaged ... hormone diet treatments into their programs as a ... see fast and effective weight loss results, it also allows ... habits to maintain their weight for the future. , Earlier ...
(Date:10/1/2014)... October 01, 2014 Anti Aging Clinic ... skin rejuvenating destination of choice, is announcing a discounted ... through to December. , “We’re doing this because we ... to our top skin clinic in Toronto,” says Dr. ... so much at Anti Aging Clinic, including laser facials, ...
(Date:10/1/2014)... 01, 2014 On Sept. 9, Chapín ... in the Martha Stewart American Made Awards (MSAMAs), an ... the country in the fields of crafts, design, food ... as a finalist in the MSAMAs, which celebrates entrepreneurs ... are improving local communities and changing the way we ...
(Date:10/1/2014)... California (PRWEB) October 01, 2014 ... to benefit a very special cause. The campaign—“Buy ... support for Paws for Veterans, a nonprofit organization ... while also rescuing shelter dogs that would otherwise ... of featured products will support monthly donations of ...
Breaking Medicine News(10 mins):Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 2Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 2Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 4Health News:Anti Aging Clinic, the GTA’s Premier Provider of Anti Aging Treatments, Announces Deal on Units of Botox 2Health News:Chicago Coffee Start-up Makes a Big Impact, Earns National Recognition 2Health News:Nordic Naturals® Inspires Support for Paws for Veterans -- ‘Buy One Bottle. Help Two Heroes.’ Initiative Kicks Off October 1 2
... Association of America Launches ,Treat It, Don,t Repeat ... a National Educational Campaign -, WASHINGTON, March 13 ... (OCD) reported their condition has,a negative impact on important ... life, according to a new national survey commissioned by ...
... NEW BRUNSWICK, N.J., March 13 Johnson &,Johnson ... Company Health Care,Conference on Thursday, March 20th at ... Colleen Goggins, Worldwide Chairman,Consumer Group will represent the ... Time)., The webcast will be available to ...
... spring, PORT WASHINGTON, N.Y., March 13 Spring ... to unemployment, foreclosures and gas at,an all-time high, consumers ... becoming more and more apprehensive about spending money,especially when ... a tough time trying to justify paying the high ...
... secure access to corporate resources for ... ... Germany-based Universa, the,country,s oldest private health insurance organization, sought a ... authentication solution. In the end, Universa selected Entrust,Inc. (Nasdaq: ...
... SOUTH SAN FRANCISCO, Calif., March 13 Rigel,Pharmaceuticals, Inc. ... Gower,the company,s chairman and chief executive officer, is scheduled ... Brothers Global Healthcare,Conference in Miami, Florida on Tuesday, March ... also scheduled to participate in a panel discussion titled,"Biotech ...
... Execution of Partnership Strategy Provides Nearly $450 Million ... and Committed Cash * 2008 Projected Net Operating Loss Less ... than $450 Million * Conference Call Webcast Thursday, March 13, 08:30 a.m. EDT ... http://www.isispharm.com , CARLSBAD, Calif., March 13 ...
Cached Medicine News:Health News:Video: New Survey Reveals More Than Half of Adults With OCD Say the Disorder Has a Negative Impact on Relationships at Home, Work and in Their Personal Life 2Health News:Video: New Survey Reveals More Than Half of Adults With OCD Say the Disorder Has a Negative Impact on Relationships at Home, Work and in Their Personal Life 3Health News:Lose Weight This Spring With Portion Control Diet Tool 2Health News:Enabling the Mobile Workforce ... Entrust Deploys Strong Authentication for German Health Insurance Expert 2Health News:Enabling the Mobile Workforce ... Entrust Deploys Strong Authentication for German Health Insurance Expert 3Health News:Rigel Announces Participation in Upcoming Investor and Partnering Conferences 2Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 2Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 3Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 4Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 5Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 6Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 7Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 8Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 9Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 10Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 11Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 12Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 13Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 14Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 15Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 16Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 17Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 18Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 19Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 20Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 21Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 22Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 23Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 24Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 25Health News:Isis Reports Financial Results and Highlights for Fiscal year 2007 26
(Date:10/1/2014)...  SI-BONE, Inc., a medical device company that pioneered the ... invasive surgical (MIS) device indicated for fusion for certain disorders ... its European operations with the formation of a GmbH and ... Manager, Germany.  Mr. Schaber will join former Kyphon colleague ... , Middle East and Asia ...
(Date:10/1/2014)... , Suisse, October 1, 2014 ... clinique et dans le domaine de l,analyse des ... lancé aujourd,hui une solution de diagnostic in vitro ... une analyse complète de la mucoviscidose dans un ... et de caractériser tous les types de variantes ...
(Date:9/30/2014)... This report analyzes the worldwide markets for Enteral ... Enteral Feeding Pumps, Nasogastric Tubes, and Others. The ... Japan , Europe , ... and Rest of World. Annual estimates and forecasts are provided ... analysis is provided for these markets. The report ...
Breaking Medicine Technology:SI-BONE, Inc. Announces European Expansion with Appointment of Eric Schaber as General Manager, Germany and Formation of GmbH 2SI-BONE, Inc. Announces European Expansion with Appointment of Eric Schaber as General Manager, Germany and Formation of GmbH 3SI-BONE, Inc. Announces European Expansion with Appointment of Eric Schaber as General Manager, Germany and Formation of GmbH 4Sophia Genetics lance une analyse complète du gène CFTR dans un essai clinique SGN 2Sophia Genetics lance une analyse complète du gène CFTR dans un essai clinique SGN 3Global Enteral Feeding Devices Industry 2Global Enteral Feeding Devices Industry 3Global Enteral Feeding Devices Industry 4Global Enteral Feeding Devices Industry 5Global Enteral Feeding Devices Industry 6Global Enteral Feeding Devices Industry 7Global Enteral Feeding Devices Industry 8Global Enteral Feeding Devices Industry 9Global Enteral Feeding Devices Industry 10Global Enteral Feeding Devices Industry 11Global Enteral Feeding Devices Industry 12Global Enteral Feeding Devices Industry 13Global Enteral Feeding Devices Industry 14Global Enteral Feeding Devices Industry 15Global Enteral Feeding Devices Industry 16Global Enteral Feeding Devices Industry 17Global Enteral Feeding Devices Industry 18Global Enteral Feeding Devices Industry 19
... BRUNSWICK, N.J., Sept. 30 Savient Pharmaceuticals, Inc. (Nasdaq: ... Court for the Southern District of New York has dismissed ... captioned Richard Sagall vs. Savient Pharmaceuticals, Inc., et al. ... The suit alleged that the Company made false and misleading ...
... HHS, Agency for Healthcare Research and Quality today ... contracts to support projects that will help people make ... effectiveness. The funding announced today covers all of AHRQ,s ... by AHRQ.   The projects will support ...
Cached Medicine Technology:Savient Pharmaceuticals Announces Dismissal of Class Action Lawsuit 2HHS Awards $473 Million in Patient-Centered Outcomes Research Funding 2
... Our Shortest, Lightest Pipettor , , The ... perfect example of how our face-to-face relationship with ... new products that make pipetting easier and more ... single channel pipettors., Gets you closer to ...
Single channel module for Finnpipette Biocontrol - Universal handle sold separately...
... The Research pro Electronic Pipette is ideal ... laboratory. Its easy-to-follow display, ergonomically-placed operating buttons, ... dispensing, reverse pipetting and diluting make this ... simple functions of a manual pipette without ...
Inquire...
Medicine Products: