Navigation Links
Even Normal Doses Of Tylenol Could Damage Liver

People who repeatedly take acetaminophen for their aches and pains could be at an increased risk for liver damage, according to the findings of a new study// .

Researchers said that patients who repeatedly approached the maximum recommended daily dose of acetaminophen showed abnormalities in blood tests, which could indicate liver damage. They added that initially they had come across liver damage in patients who took opioid hydrocodone plus acetaminophen. Previous assumption had been that it was hydrocodone that was the culprit for liver damage, but they were surprised to find that the damage was caused by acetaminophen.

"This clearly showed, much to our jaw-dropping surprise, that it had nothing to do with the opiate," said Dr. Paul Watkins, lead author of the study. "It was a previously unrecognized but pretty remarkable effect of acetaminophen alone when taken as directed for four days."

He added that acetaminophen, which is commonly available as Tylenol, has an established safety record, so the findings were unexpected. "No one should ever take a drug they don't need," he said. "But this study is not a reason to stop taking acetaminophen if you need it."

The findings of the study are published in the July 5 issue of the Journal of the American Medical Association. 145 healthy adults were given either a placebo or one of three acetaminophen/opioid combinations, or acetaminophen alone for two weeks.

The researchers found that 31 percent to 44 percent of patients in the treatment groups had a maximum ALT measurement equal to thrice the normal value. ALT is blood aminotransferase, which indicted liver disease.

"It was so unbelievable that I am conducting an ongoing study with 50 people," Watkins said. "That's not in the JAMA paper, but we're finding that it verifies the findings. Since we have decades of experience and know the safety of acetaminophen, are the tests as good as we thought they w ere? Maybe they're not good predictors as to which drugs are going to have liver problems."

Related medicine news :

1. Anti-Cancer Drug Restores Normal Cell Growth
2. Normal Blood Pressure Could Add Over 5 Years To Your Life
3. Language Delays May Not Be Normal In Children
4. Normal Delivery Is Better Than Caesarean Birth
5. Clinic Helps Women Lead Normal Lives
6. Premature Babies Can Lead Normal Lives
7. Health Services Returning To Normal
8. Rahul Mahajans Condition Improving; Vital Parametres Normal
9. Normalcy Returns To AIIMS; Venugopal Attends Office
10. Fiber And Fruit Key To Normal Weight
11. Craniofacial Surgery Gives Tijuana Teen Chance to be Normal Kid
Post Your Comments:

(Date:6/26/2016)... Viejo, California (PRWEB) , ... June 26, 2016 , ... ... Final Cut Pro X. , "Film editors can give their videos a whole new ... said Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels contains ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts ... applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention ... health care topics including advance care planning, healthcare costs and patient and family ...
(Date:6/25/2016)... Lewisville, TX (PRWEB) , ... June 25, 2016 , ... ... in the United States, named Dr. Sesan Ogunleye, as the Medical Director of its ... be the facility Medical Director of our new Mesquite location,” said Dr. James M. ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Conventional wisdom preaches ... success. In terms of the latter, setting the bar too high can result in ... than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... , ... Marcy was in a crisis. Her son James, eight, was out of control. Prone ... physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If ... at my other children and say he was going to kill them. If we ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... HOUSTON , June 23, 2016  MedSource ... platform as its e-clinical software solution of choice.  ... the best possible value to their clients by ... nowEDC.  The preferred relationship establishes nowEDC as the ... pricing for MedSource,s full-service clients.  "nowEDC has long ...
(Date:6/23/2016)... 23, 2016 Any dentist who has made an ... current process. Many of them do not even offer this ... and high laboratory costs involved. And those who ARE able ... such a high cost that the majority of today,s patients ... Parsa Zadeh , founder of Dental Evolutions Inc. and ...
(Date:6/23/2016)... 2016  In a startling report released today, National Safety ... lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... how states are tackling the worst drug crisis in recorded U.S. ... Kentucky , New Mexico , ... Of the 28 failing states, three – Michigan ...
Breaking Medicine Technology: