Navigation Links
Etanercept Reduces Psoriasis

According to a study in the June issue of Archives of Dermatology, Extended exposure to the psoriasis medication etanercept does not appear to cause more infections or adverse events.

Psoriasis, a chronic inflammatory skin disorder , usually requires long-term therapy, according to background information in the article. 'Serum and affected tissue levels of tumor necrosis factor (TNF) are elevated in patients with psoriasis compared with levels in uninvolved skin of patients with psoriasis and in healthy individuals, suggesting that TNF plays an important role in the pathogenesis of the disease,' the authors write. Etanercept, which binds with TNF, has been approved to treat several inflammatory diseases, including psoriasis.

Stephen Tyring, M.D., Ph.D., The University of Texas Health Science Center at Houston, and colleagues conducted a phase 3 randomized, double-blind trial with an open-label extension .

After a 12-week period during which 618 patients with moderate to severe psoriasis were randomly assigned to receive either placebo or 50 milligrams of etanercept twice weekly (the current recommended dosage for psoriasis) for 12 weeks, all 591 continuing patients (average age 45.7) received etanercept for up to 84 weeks.

During this open-label period, safety and efficacy evaluations were completed every 12 weeks. Psoriasis severity was measured using the Psoriasis Area and Severity Index (PASI) score, where zero means no disease and 72 is the most severe disease.

'Exposure-adjusted rates of adverse events, serious adverse events, infections and serious infections were similar for placebo and etanercept treatments,' the authors write. 'Patients responded within two weeks to etanercept, with statistically significant differences in the Psoriasis Area and Severity Index and Dermatology Life Quality Index between the etanercept and placebo groups at week 12. At week 24, after 12 weeks of open-label etanercept trea tment, patients in the original placebo group had clinical benefits comparable to those of patients in the original etanercept group.'

Improvements in PASI scores peaked at week 48, and at the end of the study, 51.6 percent of the original placebo group and 51.1 percent of the original etanercept group improved by at least 75 percent. A total of 18.3 percent of patients developed antibodies to etanercept during the study, but these antibodies did not appear to cause adverse events or reduce the drugs effectiveness.

'In conclusion, this study represents, to our knowledge, the longest continuous exposure of patients with psoriasis to 50 milligrams of etanercept biweekly and provides further insights into the safety and efficacy of high-dose etanercept therapy for the management of moderate to severe psoriasis,' the authors conclude.




'"/>




Related medicine news :

1. Drug Reduces Risk of Clogged Arteries, Veins
2. Sunshine Reduces MS Risk
3. Estrogen in Food Reduces Cancer Risk
4. Dental Procedure Reduces Preterm Births
5. Vaccine Reduces antibiotic-resistant infections in Children
6. Eating Fiber Reduces The Risk Of Heart Disease
7. Higher Statin Dose Safely Reduces Stroke and Cardiac Arrest
8. Anti-tobacco Advertising Can Reduces smoking Among Teens
9. Eating Fish Reduces Heart Disease
10. Co-trimoxazole Use Reduces Childhood AIDS –Related Death
11. NSAIDS, Reduces The Risk Of Oral Cancer But Causes Heart Attacks
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/17/2017)... (PRWEB) , ... January 17, 2017 , ... ... families from two offices in Tyler, has announced the latest beneficiary of their ... Wish Network, a nonprofit organization dedicated to fulfilling the dreams of terminally ill ...
(Date:1/17/2017)... ... January 17, 2017 , ... Many people make New Year’s resolutions or renew their commitment ... is making it easier for people who want to kick off 2017 with better smiles. ... patients. , These special offers include: , , A new ...
(Date:1/17/2017)... ... January 17, 2017 , ... ... the Montclair State University’s Athletic Training Education program forged a relationship built upon ... Education Program, which is consists of both student members and certified members ...
(Date:1/16/2017)... ... 2017 , ... Recently, patients and staff from A Forever Recovery, a holistic ... in support of the annual Binder Park Zoo Halloween celebration known as the “Zoo ... of all designs coming out to enjoy games, face painting, and lots and lots ...
(Date:1/16/2017)... (PRWEB) , ... January 16, 2017 , ... Gym Source, ... of a new showroom in East Hanover, New Jersey. , “We are elated to ... “The new innovative in-store concept is designed to give clients a seamless and motivating ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... , January 17, 2017 - First ... MENA healthcare market expected to grow by a CAGR of ... Holding, the Qatari holding company which operates globally across a number ... achieved a number of notable successes and is well-positioned for further ... ...
(Date:1/16/2017)... -- Summary GlobalData,s new report, "North ... market data on the North America Bone Densitometers market. ... volume (in units) and average prices (USD) within market ... Ultrasound (QUS). The report also provides company shares ... segements, and global corporate-level profiles of the key market ...
(Date:1/16/2017)... , Jan. 16, 2017 Derek ... Potts Law Firm, was recently appointed Liaison Counsel in ... (JCCP) for all Xarelto cases. In this role, Potts ... parties and will actively assist the Court and Co ... with Milstein Adelman Jackson Fairchild & ...
Breaking Medicine Technology: