Navigation Links
Estrogen is Important for Bone Health in Men as Well as Women

Although women are four times more likely than men to develop osteoporosis, or porous bone, one in 12 men also suffer from the disease , which can lead to debilitating - or even life-threatening - fractures, mainly of the spine, hip and wrist. The underlying causes of osteoporosis are numerous, but in women, low estrogen levels after menopause have been considered an important factor.

As for men - new research at Washington University School of Medicine in St. Louis has shown that low amounts of active estrogen metabolites also can increase their osteoporosis risk.

"Most people don't think about estrogen in men, but men actually have somewhat more estrogen on average than do postmenopausal women," says Reina Armamento-Villareal, M.D., assistant professor of medicine in the Division of Bone and Mineral Diseases and a bone specialist at Barnes-Jewish Hospital. She is senior author of a new study in the journal Calcified Tissue International.

"Research by other groups had suggested that estrogen may be more important than testosterone for maintaining bone health in men," she says. "So we designed a study to look at male estrogen levels and bone density."

When estrogen circulates in the body, it passes through the liver where several enzymes convert the standard hormone to other forms - some of these forms, or estrogen metabolites, are active and some are inactive. Individuals differ in how they process estrogen, so the levels of these estrogen metabolites will vary among people. No previous studies have addressed the role of estrogen metabolism and the forms of circulating hormone in male osteoporosis.

The Washington University researchers found that the amounts of active estrogen metabolites are a strong predictor of bone mineral density in the men they studied. Testing hormone levels and bone density as measured by DXA (dual X-ray absorptiometry) scans in 61 men age 50 or older, the researchers saw that men with higher levels of active estrogen metabolites also tended to have higher bone density. Conversely, men with lower levels of these hormones tended to have lower bone density.

Testosterone levels did not affect bone density in these study subjects. Testosterone seems to be responsible for the larger size and thicker outer layers of male bones, but estrogen is possibly a key hormone for maintaining peak bone mineral mass in men, according to the authors.

The researchers also looked at whether other factors, including smoking, alcohol consumption, daily calcium intake and body mass index (BMI) affected bone density. Only BMI correlated with bone density: Men with higher BMI tended to have higher bone density, possibly because they also had higher levels of active estrogen metabolites.

Fractures due to osteoporosis are a significant health threat in the elderly. According to Villareal, 25 percent of those who suffer a hip fracture die within a year, and 40-50 percent have some degree of disability or need nursing home care. "It's a very serious problem," she says. "People of retirement age are looking forward to their leisure time, but if they fracture a hip, there are so many things they won't be able to do."

Villareal thinks the health-care system may need to reflect what research is now revealing about estrogen in men. "It would be a good idea to measure estrogen levels in older men who present with low bone mineral density or osteoporosis," Villareal says. "Not only does estrogen and its metabolism affect bone health in men, but it may also influence the risk for prostate cancer."


'"/>




Related medicine news :

1. Estrogen lowers cancer risk
2. Estrogen Does Not Prevent Recurrent Strokes
3. Herbs With Estrogen Action Aggravate Cancer Risk
4. Osteoarthritis and Estrogen are connected
5. Estrogen Patch is Safer than Pills for Heart
6. Estrogen in Food Reduces Cancer Risk
7. Estrogen Found To Protect the Colon Against Cancer
8. The Side Effects Of Estrogen Therapy
9. The Effects Of Estrogen Therapy
10. A Likely Use For Estrogen Therapy
11. Preventing Colon Cancer With Estrogen
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2016)... ... May 26, 2016 , ... Cardiac ... significant negative impact on long-term patient survival, reports a team of UPMC researchers ... this week in the Journal of Thoracic and Cardiovascular Surgery, provide critical information ...
(Date:5/26/2016)... , ... May 26, 2016 , ... MadgeTech will be ... engineered, and manufactured in Warner, New Hampshire at the MadgeTech headquarters. With products sold ... monitoring solutions trusted by government agencies, including NASA. , In 2012, NASA strategically ...
(Date:5/26/2016)... ... 2016 , ... Dr. James Maisel will present on “Macular ... on June 4, 2016, 1:30-3:30 pm at the Farmingdale Public Library. The presentation ... of New York , is a Board Certified ophthalmologist who completed his fellowship ...
(Date:5/26/2016)... , ... May 26, 2016 , ... In an effort to provide hair restoration information ... both Snapchat users and those who do not use the app. Dr. Mohebi, the founder ... page, Dr. Mohebi Live . , Dr. Mohebi says, “The positive response to ...
(Date:5/26/2016)... ... May 26, 2016 , ... Leadership of Life ... announced the organization has earned its ISO 13485 certification, indicating the company’s quality ... all rules and policies associated with ISO quality standard 13485. , BSI ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... , May 24, 2016 ... the world , s first dual therapy ... intervention   OrbusNeich, a global company specializing ... its portfolio to include products to treat peripheral artery ... company,s first entry devices for lower limb and arteriovenous ...
(Date:5/24/2016)... , May 24, 2016 ... ™ , la première endoprothèse ... cathéters destinés à l,intervention portant sur les ...   OrbusNeich, entreprise mondiale spécialisée ... de changer la vie, a élargi son ...
(Date:5/24/2016)... -- Dutch surgeons have launched a ground-breaking medical app ... treat patients on a global scale. Medical professionals from ... and the US have already signed up for the ... a totally secure environment. Education  "Imagine a ... with a surgeon at Harvard to treat a bomb victim via ...
Breaking Medicine Technology: