Navigation Links
Estrogen Study Provides New Hope For Colon Cancer Treatment

A new research finding by Jennifer Chan and her colleagues from Dana-Farber Cancer Institute suggests// that the female hormone estrogen may hold important clues for scientists working on new therapies for colon cancer.

Using data from a long-running study of women’s health, the investigators found that postmenopausal women with colon cancer lived longer and had less likelihood of dying of the disease if they had been taking estrogen supplements within five years of their diagnosis. In this new study, published in the Dec. 20 issue of the Journal of Clinical Oncology, investigators examined the effect of estrogen use on the survival of older women already diagnosed with the disease.

While estrogen use has dropped sharply among postmenopausal women in recent years, due to concerns about its role in heart disease and breast cancer, numerous studies have shown it significantly lowers the chances of developing colorectal cancer. The researchers stress that these findings do not mean estrogen should be viewed as a treatment or preventive therapy for colon cancer, considering the other health risks associated with its use. However, the research may guide the development of other, safer colon cancer drugs.

"This study provides a rationale to further study the basic mechanism by which estrogen influences the development and progression of colon cancer," states lead author Jennifer Chan, MD, MPH, of Dana-Farber. "By understanding how estrogen offers potentially beneficial effects in some types of cells yet deleterious effects in others, it may be possible to design therapies that are effective against colon cancer without posing a significant risk of other problems."

Estrogen supplements have been taken by millions of older women as a way of staving off some of the problems associated with menopause, such as hot flashes and bone loss, but the number has declined considerably since 2002. That year, investigators reported that, for many women, the supplements carried more health risks than benefits. The research by Chan and her colleagues drew on data from 834 postmenopausal women enrolled in the Nurses' Health Study -- which has tracked the health of more than 100,000 female nurses since 1976 -- who had been diagnosed with colon cancer between 1976 and 2000. The researchers found that, compared to women who had never used estrogen, those using the hormone at the time of diagnosis had a 36 percent lower chance of dying of colon cancer and a 26 percent lower chance of dying of any cause. The benefit was most pronounced in women who used estrogen for less than five years. Using it for longer, however, did not seem to provide a similar advantage.

The authors do not know why using estrogen for more than five years did not improve women's chances of survival. They theorize that colon tumors that developed in women who had used estrogen for many years may have been less susceptible to estrogen’s growth-slowing effects. The precise way by which estrogen foils the growth of colon cancer cells is unclear, as well. The study authors offer three possibilities: the hormone directly suppresses the cells' growth; it decreases the production of bile acids which are known to spur cancer; or it blocks certain genetic changes within colon cells that lead to cancer. "Further efforts are needed to bring these mechanisms to light," comments Chan, who is also an instructor in medicine at Harvard Medical School. “Our study provides an important rationale for undertaking those studies."



Source-Eurekalert
SI
'"/>




Related medicine news :

1. Estrogen lowers cancer risk
2. Estrogen Does Not Prevent Recurrent Strokes
3. Herbs With Estrogen Action Aggravate Cancer Risk
4. Osteoarthritis and Estrogen are connected
5. Estrogen Patch is Safer than Pills for Heart
6. Estrogen in Food Reduces Cancer Risk
7. Estrogen Found To Protect the Colon Against Cancer
8. The Side Effects Of Estrogen Therapy
9. The Effects Of Estrogen Therapy
10. A Likely Use For Estrogen Therapy
11. Preventing Colon Cancer With Estrogen
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/16/2017)... , ... January 16, 2017 , ... ... today announced the addition of Victor Giamos, MD to their medical staff, according ... Managing Partner at North Shore Eye Care, a division of SightMD. Dr. Giamos ...
(Date:1/16/2017)... ... January 16, 2017 , ... Atlanta-based incentive company ... innovator in the wheelchair accessibility industry, BraunAbility . Incentive Solutions will provide ... wheelchair accessible vehicles. With this new incentive plan, BraunAbility plans to continue their ...
(Date:1/16/2017)... ... January 16, 2017 , ... ... Aesthetic Surgery Journal , the official journal of The American Society for Aesthetic ... retraction surgery. The procedure is designed to correct drooping, retracted lower eyelids, which ...
(Date:1/16/2017)... ... January 16, 2017 , ... San Francisco dentist, Dr. Ben Amini , ... scanning device which is capable of taking digital impressions of teeth and gums. Conventional ... CAD CAM restorations , in terms of speed, efficiency and patient comfort. Increasingly, ...
(Date:1/15/2017)... York, NY (PRWEB) , ... January 15, 2017 , ... ... strategic accounts in the United States for the asthma & allergy friendly mark. This ... America to independently test and identify consumer products to be more suitable for the ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... Jan. 16, 2017  Today, Analytics 4 Life (A4L), ... announced its expansion into JLABS @ Toronto ... science incubators. As a resident in the space, A4L ... device development and commercialization expertise. JLABS @ ... innovation center that provides a flexible environment for start-up ...
(Date:1/15/2017)... , January 16, 2017 Le conseil ... à base de collagène pour la régénération de tissus humains, ... poste de directeur général avec effet immédiat. ... Bill est un dirigeant ... occupé plusieurs postes de gestion générale et de direction au ...
(Date:1/13/2017)... Stock-Callers is currently reviewing the following Medical Appliances ... WMGI ), Varian Medical Systems Inc. (NYSE: VAR ... NuVasive Inc. (NASDAQ: NUVA ). These companies belong ... finish on Thursday, January 12 th , 2017, with the ... health care companies in the S&P 500 were down less ...
Breaking Medicine Technology: