Navigation Links
Estrogen Protects Liver After Traumatic Injury

Birmingham, AL -- Researchers have identified the receptor pathway used by estrogen to decrease liver injury after trauma and hemorrhage//. The related report by Hsieh et al, “G protein-coupled receptor 30-dependent protein kinase A pathway is critical in nongenomic effects of estrogen in attenuating liver injury after trauma-hemorrhage,” appears in the April issue of The American Journal of Pathology and is accompanied by a commentary.

Research has shown that estrogen improves host response after traumatic injury, but the cellular pathway used has been unknown. Estrogen directs cellular processes in two ways: by interacting with DNA to produce new protein or by binding cell surface receptors to initiate rapid protein signaling. Current data points to cell surface receptors in improving recovery from liver injury following soft-tissue trauma and major blood loss, but which receptor is responsible for producing this effect was not known until this study was performed.

Research directed by Irshad H. Chaudry at the University of Alabama at Birmingham sought to answer this question using an established rat model of liver injury and hemorrhage. They examined the cell surface receptor pathways by treating rats with a form of estrogen that cannot enter cells, thus acting only via cell surface interactions.

As expected, rats affected by trauma-hemorrhage released high levels of liver enzymes associated with liver damage. However, treatment with surface estrogen decreased the amount of enzymes released. Further, such treatment also maintained normal levels of cell-protective Bcl-2 and active protein kinase A, which were otherwise decreased by trauma-hemorrhage.

The researchers then examined two possible receptors, G protein-coupled receptor 30 (GPR30) and estrogen receptor-alpha, for their role in mediating estrogen’s protective effects. Receptor expression on the cell surface was diminished by blocking protein production in cultured l
'"/>




Page: 1 2

Related medicine news :

1. Estrogen lowers cancer risk
2. Estrogen Does Not Prevent Recurrent Strokes
3. Herbs With Estrogen Action Aggravate Cancer Risk
4. Osteoarthritis and Estrogen are connected
5. Estrogen Patch is Safer than Pills for Heart
6. Estrogen in Food Reduces Cancer Risk
7. Estrogen Found To Protect the Colon Against Cancer
8. The Side Effects Of Estrogen Therapy
9. The Effects Of Estrogen Therapy
10. A Likely Use For Estrogen Therapy
11. Preventing Colon Cancer With Estrogen
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Estrogen Protects Liver After Traumatic Injury

(Date:10/22/2014)... On October 22, CBS will air ... diseases both fictional and real. The Charles E ... committed to advocacy and philanthropy in the battle against ... opportunity to impart truth and clarity about this misunderstood ... many misconceptions about Morgellons Disease (MD) and ...
(Date:10/22/2014)... Amy Norton HealthDay Reporter ... remain riveted on the three Ebola cases in Dallas. But, ... health threat to Americans. President Barack Obama on Friday ... the virus, which has infected two Dallas nurses who cared ... at Texas Health Presbyterian Hospital. But the U.S. cases ...
(Date:10/22/2014)... 22, 2014 Hay House is pleased to ... and Upgrade Your Life (Paperback; $10.82) written by the highly ... Recovery. This book is meant to help readers of ... of recovery. , Recovery 2.0 is not the average ... 2.0 is a guide for what comes next. ...
(Date:10/22/2014)... 2014 Healthcare professionals who are ... education at home or on-the-go via laptops, tablets ... brand new, premium Seminar-on-Demand CE courses. The new ... 2,000 hours of CE course offerings, ... experience. With such a diverse library, there’s something ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 Richard Carlson, ... an industry leader with over 25 years experience. ... leader in the areas related to EDI, B2B Commerce, ... is an Editorial Advisory Board member for Pharmaceutical Commerce ... Blue Fin Group is a management and technology ...
Breaking Medicine News(10 mins):Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 2Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 3Health News:Ebola Anxiety: A Bigger Threat Now Than the Virus Itself 2Health News:Ebola Anxiety: A Bigger Threat Now Than the Virus Itself 3Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 3Health News:Top Provider of Continuing Education at Home Releases 20 New Online Courses 2Health News:Rich Carlson and Marc Duey to Hold Workshop at CBI’s Specialty Pharmacy and Distribution Networks Conference 2
... , SCOTTSDALE, Ariz., Nov. 12 Healthcare Trust of ... investment trust, announced the execution of a Purchase and ... building located in Spartanburg, South Carolina for approximately $16,250,000. ... number of conditions. , The approximate 108,500 SF Mary ...
... MONTREAL, Nov. 12 The International Peak Performance Symposium ... - Via Scarlatti, 33 (close to Stazione Centrale), Milan ... , The conference will focus on the benefits that ... Peak Performance both in Sports and Business. Modern approaches ...
... found elevated amounts of protein involved in blood-brain barrier ... have a biological effect on the brain, but it,s ... risks, a Swedish medical researcher reports. , Fredrik Soderqvist, ... phone users and discovered they had elevated levels of ...
... that lead to myotonic dystrophy , THURSDAY, Nov. 12 (HealthDay ... pneumonia might serve as an effective treatment against a type ... mice and found that it appears to combat genetic defects ... types of muscular dystrophy. The muscle-wasting condition is also known ...
... Rats fed sugary chow suffered withdrawal when regular meals returned , ... of dieting? Join the club. But new research in rats hints ... as kicking drug addiction. , In the study, rats weaned off ... withdrawing from drugs and alcohol. , Rat brains aren,t the same ...
... ... facility in Lake Success, NY. The facility will house some of the practice’s ... M.D., Neuro-Ophthalmologist Scott Uretsky, M.D., Neuropsychologist Gad E. Klein, Ph.D. and Neurophysiologist Marat ... needs of pediatric patients. , ...
Cached Medicine News:Health News:Healthcare Trust of America, Inc. Executes Agreement to Acquire a 108,500 SF Medical Office Building Located in Spartanburg, South Carolina 2Health News:Peak Performance, Neurofeedback and Biofeedback: New Frontiers of Empowerment From, and In, Sport 2Health News:Wireless Phones Alter Levels of Brain Chemical 2Health News:Study Links Yo-Yo Dieting to Addiction 2Health News:Study Links Yo-Yo Dieting to Addiction 3Health News:Neurological Surgery, P.C., of Long Island, NY, Adds New Specialists and Opens New Flagship Facility in Lake Success, NY 2Health News:Neurological Surgery, P.C., of Long Island, NY, Adds New Specialists and Opens New Flagship Facility in Lake Success, NY 3
(Date:10/22/2014)... BASKING RIDGE, N.J. , Oct. 22, 2014 ... (RMANJ), a world-renowned leader in the field ... more rapid approach to embryonic screening. The research ... American Society for Reproductive Medicine (ASRM) meeting in ... chromosome screening (CCS) and single gene defect (SGD) ...
(Date:10/22/2014)... AVACEN Medical announced today that its AVACEN ... clearance by the U.S. Food and Drug Administration. This ... the Internet for: the temporary relief of joint ... and sprains . Logo - http://photos.prnewswire.com/prnh/20141021/153513 ... is a sophisticated medical device incorporating over 3,000 firmware ...
(Date:10/22/2014)... YARDLEY, Pa. , Oct. 22, 2014 /PRNewswire/ ... of their animal health medications, a Global Pharmaceutical ... and Antares serialization technology and turnkey solution to ... Photo - http://photos.prnewswire.com/prnh/20141021/153438 ... The product that was serialized and aggregated by ...
Breaking Medicine Technology:New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 2New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 3AVACEN Medical Announces FDA Clearance of First Medical Device with Internal Game Mode 2Xyntek and Antares Serialization Solution Protects Pets Too! 2
... Mesa Laboratories, Inc. (Nasdaq: MLAB ) today announced that ... of the Company,s Board of Directors, effectively immediately. , ... "Paul,s experience and insight have been extremely helpful ... J. Sullivan , President and CEO.  "Paul managed Mesa,s Medical product line ...
... July 8 Roxane Laboratories, Inc. announced today the approval ... by the U.S. Food and Drug Administration.  The product is available ... nationwide. , , , ... Laboratories, Anastrozole Tablets are AB rated to ARIMIDEX® (anastrozole) tablets.  Annual ...
Cached Medicine Technology:Paul D. Duke Resigns From Mesa's Board of Directors 2Roxane Laboratories, Inc. Announces the Launch of Anastrozole Tablets 2Roxane Laboratories, Inc. Announces the Launch of Anastrozole Tablets 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: