Navigation Links
Estrogen Linked to Immune Surveillance in Breast Cancer

Estrogen is known to enhance the growth and migration of breast cancer cells. Now researchers at the University of Illinois at Urbana-Champaign have found that estrogen// also can shield breast cancer cells from immune cells.

In a study published online this week in Oncogene, the researchers report that estrogen induces the expression of an inhibitor that blocks immune cells’ ability to kill tumor cells. This is the first study to identify estrogen’s role in shielding breast cancer cells from the action of immune cells.

The researchers analyzed estrogen’s role in the cascade of events that occurs when immune cells, called natural killer cells, encounter a tumor cell. Under normal conditions, natural killer cells release granules that contain enzymes, called granzymes, which enter and kill the tumor cell.

The research team found that when estrogen binds to an estrogen receptor the complex promotes production of a granzyme inhibitor, proteinase inhibitor 9 (PI-9). The inhibitor binds the granzyme, preventing it from initiating the molecular cascade that kills tumor cells.

“It wasn’t known that estrogen could do this in breast cancer cells,” said principal investigator David J. Shapiro, a professor of biochemistry in the School of Molecular and Cellular Biology. “The amounts of estrogen required to do this are quite small.”

U. of I. graduate student Xinguo Jiang also found that when breast cancer cells that contain very high levels of estrogen receptor protein are exposed to low levels of estrogen, they produce large quantities of the granzyme inhibitor and become highly resistant to immune attack.

The researchers were able to show that estrogen’s effect on PI-9 production was the sole mechanism by which estrogen interfered with the natural killer cells’ ability to kill off breast cancer cells. They did so by blocking PI-9 production in the breast cancer cells exposed to estrogen. When these brea st cancer cells were targeted by natural killer cells, they were efficiently killed off, even when significant levels of estrogen and estrogen receptor were present.

Estrogens are known to cause only a few types of cancers, Shapiro said. PI-9 also has been implicated in other cancers. High levels of PI-9 in some lymphomas, for example, are associated with poor prognoses.

This study demonstrates how basic research can have important and unanticipated implications for understanding diseases such as breast cancer, Shapiro said. The finding that estrogens stimulate PI-9 production could eventually help drug designers develop new tests – and targets – for breast cancer therapy.

The research team included collaborators from the University of Wisconsin at Madison.



Source: Bio-Bio Technoogy
SRI
'"/>




Related medicine news :

1. Estrogen lowers cancer risk
2. Estrogen Does Not Prevent Recurrent Strokes
3. Herbs With Estrogen Action Aggravate Cancer Risk
4. Osteoarthritis and Estrogen are connected
5. Estrogen Patch is Safer than Pills for Heart
6. Estrogen in Food Reduces Cancer Risk
7. Estrogen Found To Protect the Colon Against Cancer
8. The Side Effects Of Estrogen Therapy
9. The Effects Of Estrogen Therapy
10. A Likely Use For Estrogen Therapy
11. Preventing Colon Cancer With Estrogen
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... While it’s ... poses a problem. Fortunately, an inventor from Austin, Texas, has identified a solution. , ... medication in darkness or restricted lighting. As such, it eliminates the need to turn ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Lori R. Somekh, ... member of ElderCounsel, a national organization of elder law and special needs planning attorneys. ... and rules. It also provides a forum to network with elder law attorneys nationwide,” ...
(Date:10/13/2017)... ... 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at ... towards children of all ages; it is a non-competitive, non-timed event, which is all ...
(Date:10/13/2017)... ... 2017 , ... “America On The Brink”: the Christian history of the United ... the creation of published author, William Nowers. Captain Nowers and his wife, Millie, ... spent thirty years in the Navy. Following his career as a naval aviator ...
(Date:10/12/2017)... ... 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of ... innovative new design of the shoulder pad. The shoulder pad provides optimal support ... your pain while using cold therapy. By utilizing ice and water that is circulated ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)...  BioPharmX Corporation (NYSE MKT: BPMX) researchers were part ... way to use nonlinear optical imaging to confirm the ... A presentation ... how researchers from BioPharmX and the Wellman Center for ... suite of imaging techniques in what is called "Pharmacokinetic ...
(Date:10/10/2017)... 10, 2017  NDS received FDA 510(k) clearance in May 2017 ... display stand specifically designed for endoscopy environments. An innovative secondary monitor ... clinical solution to support the improvement of patient outcomes, procedural efficiency, ... ... ...
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare ... CPR training aide "cprCUBE" on Kickstarter. The device will ... during cardiac arrests with better efficiency compared to the ... offers real-time feedback on efficacy of the compression for ... campaign has a goal to raise $5,000. ...
Breaking Medicine Technology: